Genetic Basis for Inherited Cardiovascular Disease

Contact Information:		Dr. Daniel P. Judge (410) 614-3085

Laboratory Location:		Ross 1049; 720 Rutland Ave Baltimore, MD 21205

Research Focus:		Dr. Judge's laboratory is primarily involved with research regarding the genetic basis for inherited forms of cardiovascular disease. These include familial forms of cardiomyopathy (ARVD, HCM, Dilated, and Restrictive), and genetic aortic diseases (Marfan syndrome, Loeys-Dietz syndrome).

Funding Support:		NIH/NHLBI Donald W. Reynolds Foundation Foundation Leducq JHU Ladies In Red Dana and Albert "Cubby" Broccoli Center for Aortic Diseases

Active Projects:		Dr. Judge's laboratory is primarily involved with research regarding the genetic basis for inherited forms of cardiovascular disease. Research projects include: Genetic investigation of various forms of cardiomyopathy (ARVD, hypertrophic, dilated, and restrictive); Genetic factors contributing to sudden cardiac death; Relationship between inherited forms of cardiomyopathy and related forms of muscular dystrophy; and The causes and best treatments for the cardiovascular manifestations of Marfan syndrome and related vascular diseases.

Laboratory Collaborators:		Hal Dietz, MD Eduardo Marbán, MD, PhD Peter Spooner, PhD Hugh Calkins, MD Ronald D. Cohn, MD Kathryn R. Wagner, MD, PhD Gordon Tomaselli, MD Robert A. Levine, MD Bart Loeys, MD, PhD Jeffrey Towbin, MD, PhD Nazareno Paolocci, PhD Suneel S. Apte, M.B.B.S., D.Phil Carolyn Y. Ho, MD (and others)

Selected Bibliography:		Judge DP, Biery NJ, Keene DR, et al. “Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome.” Journal of Clinical Investigation 2004, 114:172-81. Loeys BL, Chen J, Neptune ER, Judge DP, et al, “A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.” Nature Genetics 2005; 37:275-81. Dalal D, ... Calkins H, Judge, DP. “Clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy due to mutations in plakophilin-2.” Circulation 2006; 113:1641-9. Habashi JP, Judge DP(co-first author),... and Dietz HC. “Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome.” Science 2006; 312:117-21. Awad MM, Dalal D, ..., Judge DP. “DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy.” American Journal of Human Genetics, 2006; 79:136-42. Cohn RD, van Erp C, Habashi JP, ..., Judge DP, Ward CW, Dietz HC. “Angiotensin II Type 1 Receptor Blockade Attenuates TGF?-induced Failure of Muscle Regeneration in Multiple Myopathic States.” Nature Medicine, 2007; 13:204-210.