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Heart & Vascular Institute

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Cardiology Bioengineering Laboratory


Principal Investigator: Henry R. Halperin, MD, MA

Laboratory Manager: Menekhem M. Zviman, PhD

Laboratory Location:

Cardiology Bioengineering Laboratory, Traylor 903
The Johns Hopkins Hospital

Research Focus:

Our laboratory focuses on the applications of advanced imaging techniques for arrhythmia management. The primary limitation of current fluoroscopy guided techniques for ablation of cardiac arrhythmia is the inability to visualize soft tissues and 3-dimensional anatomic relationships. Implementation of alternative advanced modalities has the potential to improve complex ablation procedures by guiding catheter placement, visualizing abnormal scar tissue, reducing procedural time devoted to mapping, and eliminating patient and operator exposure to radiation.      

Active Projects:

  • Physiological differences between isolated hearts in ventricular fibrillation and pulseless electrical activity
  • Successful ablation sites in ischemic ventricular tachycardia in a porcine model and the correlation to Magnetic Resonance Imaging
  • Magnetic resonance imaging guided radiofrequency ablation of canine atrial fibrillation
  • MR-guided diagnosis and intervention for arrhythmias
  • Physiological and metabolic effects of interruptions in chest compressions during cardiopulmonary resuscitation

Laboratory Collaborators:

Selected Bibliography:

1. Borhan, B.; Nazarian, S.; Stocking, E.M.; Kurth, M.J.; Hammock, B.D.; An efficient preparation of 18O-labeled epoxides; Journal of Organic Chemistry, 59, 15:  4316-4318, 1994.

2. Borhan, B.; Mebrahtu, T.; Nazarian, S.; Kurth, M.J.; Hammock, B.D.; Improved radiolabeled substrates for soluble epoxide hydrolase; Analytical Biochemistry, 231, 1:  188-200, 1995.

3. Kantorowski, E. J.; Borhan, B.; Nazarian, S.; Kurth, M.J.; Cyclopropylcarbinyl radical mediated ring expansion to seven membered carbocycles; Tetrahedron Letters, 39, 2483-2486, 1998.

4. Qiu, D.;  Zhao, G.;  Aoki, Y.;  Shi, L.;  Uyei, A.;  Nazarian, S.;  Ng, J.C.;  Kao, P.N.;  Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kB transcriptional activation, Journal of Biological Chemistry, 274, 19: 13443-13450, 1999.

5. Nazarian, S.; Knight, BP; Dickfeld; T.L; Zviman, M.M; Jayanti, V.B.; Amundson, D.; Hanlin, J.; Castleberry, J.; Smith, M.F.; Blankenship, L.; Halperin, H.R.; Ferguson, T.B.; Berger, R.D.; Direct Visualization of Coronary Sinus Ostium and Branches with a Flexible Steerable Fiberoptic Infrared Endoscope, Heart Rhythm, 2: 844-848, 2005.

6. Knight, B.P.; Burke, M.C.;Hong, T.E.; McAuley, A.; Amundson, D.; Hanlin, J.; Blankenship, L.; Ferguson, T.B.; Nazarian, S.; Berger, R.D.; Direct imaging of transvenous radiofrequency cardiac ablation using a steerable fiberoptic infrared endoscope, Heart Rhythm, 2:1116 –1121, 2005.

7. Nazarian, S.; Maisel, W.H.; Miles, J.S.; Tsang, S.; Stevenson, L.W.; Stevenson, W.G.; Impact of Defibrillators in Advanced Heart Failure, American Heart Journal, 150(5): 955-60, November 2005.

8. Nazarian, S.; Bluemke, D.A.; Lardo, A.C.; Zviman, M.M.; Watkins, S.P.; Dickfeld, T.L.; Meininger, G.R.; Roguin, A.; Calkins, H.; Tomaselli, G.F.; Weiss, R.G.; Berger, R.D.; Lima, J.A.C.; Halperin, H.R.; Magnetic Resonance Assessment of the Substrate for Inducible Ventricular Tachycardia in Non-Ischemic Cardiomyopathy, Issue Highlights, Circulation, 112(18): 2821-5, November 1, 2005.

9. Lardo, A.C.; Cordeiro, M.A.; Silva, C.; Amado, L.C.; George, R.T.; Saliaris, A.P.; Schuleri, K.H.; Fernandes, V.R.; Zviman, M.; Nazarian, S.; Halperin, H.R.; Wu, K.C.; Hare, J.M.; Lima, J.A.; Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: Characterization of myocyte death, microvascular obstruction, and chronic scar, Circulation. 2006 Jan 24;113(3):394-404.

10. Cheema, A,; Dong, J.; Dalal, D.; Vasamreddy, C.R.; Marine, J.E.; Henrikson, C. A.; Spragg, D.; Cheng, A.; Nazarian, S.; Sinha, S.; Halperin, H.; Berger, R.; Calkins, H. Long-Term Safety and Efficacy of Circumferential Ablation with Pulmonary Vein Isolation. Journal of Cardiovascular Electrophysiology, 2006; 17 (10), 1080-1085.

11. Cheema, A.; Vasamreddy, C.R.; Dalal, D.; Marine, J.E.; Dong, J.; Henrikson, C.A.; Spragg, D.; Cheng, A.; Nazarian, S.; Sinha, S.; Halperin, H.; Berger, R.; Calkins. H. Long-term single procedure efficacy of catheter ablation of atrial fibrillation. Journal of Cardiovascular Electrophysiology, 2006 Apr; 15(3):145-55. 

12. Nazarian, S.; Roguin, A.; Zviman, M.M.; Lardo, A.C.; Dickfeld, T.L.; Calkins, H.; Berger, R.D.; Bluemke, D.A.; Halperin, H.R.; Clinical Utility and Safety of a Protocol for Non-Cardiac and Cardiac Magnetic Resonance Imaging of Patients with Permanent Pacemakers and Implantable Cardioverter Defibrillators at 1.5 Tesla, Issue Highlights, Circulation, 2006 Sep; 114:1277-1284.

13. Dickfeld, T.; Kato, R.; Zviman, M.; Nazarian, S.; Dong, J.; Ashikaga, H.; Lardo, A.C.; Berger, R.D.; Calkins, H.; Halperin, H.; Characterization of acute and subacute radiofrequency ablation lesions with nonenhanced magnetic resonance imaging, Heart Rhythm. 2007 Feb; 4(2): 208-14.

14. Cheema, A.; Dong, J.; Dalal, D.; Marine, J.E.; Henrikson, C.A.; Spragg, D.; Cheng, A.; Nazarian, S.; Bilchick, K.; Sinha, S.; Scherr, D.; Almasry, I.; Halperin, H.; Berger, R.; Calkins, H.; Incidence and Time Course of Early Recovery of Pulmonary Vein Conduction after Catheter Ablation of Atrial Fibrillation, J Cardiovasc Electrophysiol. May 2007; 18: 1-5.