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Becker Lab Publications

Selected Publications:

  1. Ambrosio G, Becker LC, Hutchins GM, Weisman HF, Weisfeldt ML: Reduction in experimental infarct size by recombinant human superoxide dismutase: Insights into the pathophysiology of reperfusion injury.  Circulation 1986; 74:1424-33.

  2. Becker LC, Ambrosio G: Myocardial consequences of reperfusion. Prog in Cardiovasc Dis 1987; 30: 23-44.

  3. Litt MR, Jeremy RW, Weisman HF, Winkelstein JA, Becker LC: Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 min ischemia. Evidence for myocardial reperfusion injury.  Circulation 1989; 80:1816-1827.

  4. Jeremy RW, Links JM, Becker LC: The progressive failure of coronary flow during reperfusion of myocardial infarction. Documentation of the no-reflow phenomenon with positron emission tomography.  J Am Coll Cardiol 1990; 16:695-704.

  5. Lefer DJ, Shandelya SML, Serrano CV Jr, Becker LC, Kuppusamy P, Zweier JL: Cardioprotective actions of a monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury.  Circulation 1993; 88:1779-1787.

  6. Albertine KH, Weyrich AS, Ma X, Lefer DJ, Becker LC, Lefer AM: Quantificaion of neutrophil migration following myocardial ischemia and reperfusion in cats and dogs. J Leukocyte Biol 1994; 55: 557-566.

  7. Perez RG, Arai M, Richardson C, DiPaula A, Siu C, Matsumoto N, Hildreth JEK, Mariscalco MM, Smith CW, Becker LC: Factors modifying the protective effect of anti-CD18 antibodies on myocardial reperfusion injury in dogs. Am J Physiol 1996; 270 (Heart Circ Physiol 39):H53-H64.

  8. Arai M, Lefer DJ, So T, DiPaula A, Aversano T, Becker LC: An anti-CD18 antibody limits infarct size and preserves left ventricular function in dogs with ischemia and 48 hours reperfusion. J Am Coll Cardiol 1996; 27:1278-1285.

  9. Crawford LE, Milliken EE, Irani K, Zweier JL, Becker LC, Johnson T, Eissa NT, Crystal RG, Finkel T, Goldschmidt-Clermont PJ: Superoxide mediated actin response in post-hypoxic endothelial cells. J Biol Chem 1996; 271:26863-26867.

  10. Matsumura K, Jeremy RW, Schaper J, Becker LC: Progression of myocardial necrosis during reperfusion of ischemic myocardium. Circulation 1998; 97:795-804.

  11. Ambrosio G, Zweier JL, Becker LC. Apoptosis is prevented by administration of superoxide dismutase in dogs with reperfused myocardial infarction.  Basic Res Cardiol 1998; 93:94-96.

  12. Becker LC, Jeremy R, Schaper J, Schaper W: Ultrastructural assessment of myocardial necrosis occurring during ischemia and 3-h reperfusion in the dog. Am J Physiol 1999; 277:H243-H252.

  13. Arai M, Masui Y, Goldschmidt-Clermont P, DiPaula A, Siu C, Kondo T, Becker LC: P selectin inhibition prevents early neutrophil activation but provides limited protection against myocardial injury in dogs with ischemia and 48 hours reperfusion. J Amer Coll Cardiol 1999; 34:280-8.

  14. Takatsu H, Duncker CM, Arai M, Becker LC: Granulocyte accumulation in ischemic/reperfused myocardium: Assessment with a technetium-99m labeled antigranulocyte monoclonal antibody in the dog. J Nuclear Cardiol 1999; 6:641-50.

  15. Sun B, Fan H, Honda T, Fujimaki R, Lafond-Walker A, Masui Y, Lowenstein CJ, Becker LC: Activation of NF[kappa]B and expression of ICAM-1 in ischemic-reperfused canine myocardium. J Mol Cell Cardiol 2001; 33:109-19.

  16. Duilio C, Ambrosio G, Kuppusamy P, DiPaula A, Becker LC, Zweier JL: Neutrophils are primary source of O(2) radicals during reperfusion after prolonged myocardial ischemia. Am J Physiol 2001; 280:H2649-57.

  17. Fan H, Sun B, Gu Q, Lafond-Walker A, Cao S, Becker LC: Oxygen radicals trigger activation of transcription factors NF[kappa]B and AP-1 and upregulation of the ICAM-1 gene in ischemic-reperfused canine myocardium. Am J Physiol 2002; 282:H1778-H1786.

  18. Yang XP, Irani K, Mattagajasingh S, Dipaula A, Khanday F, Ozaki M, Fox-Talbot K, Baldwin WM 3rd, Becker LC. Signal transducer and activator of transcription 3alpha and specificity protein 1 interact to upregulate intercellular adhesion molecule-1 in ischemic-reperfused myocardium and vascular endothelium. Arterioscler Thomb Vasc Biol 2005; 25:1395-1400.

  19. Gu Q, Yang XP, Bonde P, DiPaula A, Fox-Talbot K, Becker LC. Inhibition of TNF-alpha reduces myocardial injury and proinflammatory pathways following ischemia-reperfusion in the dog. J Cardiovasc Pharmacol 2006;48:320-8.

  20. Yang XP, Mattagajasingh S, Su S, Chen G, Cai Z, Fox-Talbot K, Irani K, Becker LC: Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak-Stat5 Pathway. Circ Res 2007;101:1001-8.

  21. Herrera-Galeano JE, Becker DM, Wilson AF, Yanek LR, Bray P, Vaidya D, Faraday N, Becker LC. A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability. Arterioscler Thromb Vasc Biol. 2008;28:1484-90.

  22. Cai ZP, Shen Z, Kaer LV, Becker LC. Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. FASEB J 2008; 22:4248-4257.

  23. Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, Trush MA, Semenza GL. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res. 2008;77:463-70.

  24. Cai Z, Semenza GL. Is 15-min ischemia too lethal to be an ischemic preconditioning stimulus? Circ Res. 2006;99:e86.

  25. Cai Z, Semenza GL. PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning. Circ Res. 2005;97:1351-9.

  26. Cai Z, Semenza GL. Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury. Circulation. 2004;109:2050-3

  27. Cai Z, Manalo DJ, Wei G, Rodriguez ER, Fox-Talbot K, Lu H, Zweier JL, SemenzaGL. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation. 2003;108:79-85.

  28. Cai ZP, Shen Z, Van Kaer L, Becker L. Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit LMP-2 deficiency. FASEB J 2008;22:4248-57.

Recent Abstracts:

  1. Tritto I, Di Ianni M, Falzetti F, Bettini M, Coiro S, Zuchi C, Porchetta I, Moretti L, Becker LC, Tabilio A, Ambrosio G. In vivo real time monitoring of stem cells homing in postischemic tissues.  Circulation 2008; 118 Suppl. 2: S520.

  2. Kral BG, Faraday N, Herrera-Galeano JE, Vaidya D, Yanek LR, Moy TF, Becker DM, Becker LC. Novel variants in mitogen-activated protein kinase (MAPK) genes are associated with platelet responsiveness to aspirin. Circulation 2008; 118 Suppl. 2: S390.

  3. Zu LY, Bedja D, Becker LC, Cai ZP. Inducible 20S beta subunit LMP-2 is down-regulated in db/db mouse hearts with diabetic cardiomyopathy. Ciculation 2008; 118 Suppl. 2: S546.

  4. Yang XP, Becker LC, Becker DM, Bocharov AV, Freeman L, Biesecker L, Remaley AT. Mutations in scavenger receptor-BI/II result in a novel dyslipidemia with increased HDL and lipoprotein(a). Circulation 2008; 118 Suppl. 2: S559.

  5. Cal ZP, Shen Z, Becker LC. PTEN knockdown induces cardioprotection in mouse hearts. Circulation 2007; 116 Suppl. S67.

  6. Cai ZP, Shen Z, Becker LC. Rac1 deletion impairs ischemic preconditioning in mouse hearts. Circulation 2007; 116 Suppl. S200.

  7. Mattagajasingh S, Irani K, Mattagajasingh I, Yang X, Becker LC. Rac1 mediates Stat3 activation in vascular endothelium following hypoxia-reoxygenation. Circulation 2006;114 Suppl. S866. .