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Cammarato Lab Publications

View Anthony Cammarato's publications on PubMed

Original Research:

1: Cammarato A, Hatch V, Saide J, Craig R, Sparrow JC, Tobacman LS, Lehman W. Drosophila muscle regulation characterized by electron microscopy and three-dimensional reconstruction of thin filament mutants. Biophys J. 2004 Mar;86(3):1618-24. PubMed PMID: 14990488; PubMed Central PMCID: PMC1303996.

2: Ayme-Southgate A, Saide J, Southgate R, Bounaix C, Cammarato A, Patel S, Wussler C. In indirect flight muscles Drosophila projectin has a short PEVK domain, and its NH2-terminus is embedded at the Z-band. J Muscle Res Cell Motil. 2005;26(6-8):467-77. PubMed PMID: 16465474.

3: Cammarato A, Craig R, Sparrow JC, Lehman W. E93K charge reversal on actin perturbs steric regulation of thin filaments. J Mol Biol. 2005 Apr 15;347(5):889-94. PubMed PMID: 15784249.

4: Melkani GC, Cammarato A, Bernstein SI. alphaB-crystallin maintains skeletal muscle myosin enzymatic activity and prevents its aggregation under heat-shock stress. J Mol Biol. 2006 May 5;358(3):635-45. Epub 2006 Mar 3. PubMed PMID: 16546210.

5: Suggs JA, Cammarato A, Kronert WA, Nikkhoy M, Dambacher CM, Megighian A, Bernstein SI. Alternative S2 hinge regions of the myosin rod differentially affect muscle function, myofibril dimensions and myosin tail length. J Mol Biol. 2007 Apr 13;367(5):1312-29. Epub 2007 Jan 23. PubMed PMID: 17316684; PubMed Central PMCID: PMC1965590.

6: Cammarato A, Dambacher CM, Knowles AF, Kronert WA, Bodmer R, Ocorr K, Bernstein SI. Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles. Mol Biol Cell. 2008 Feb;19(2):553-62. Epub 2007 Nov 28. PubMed PMID: 18045988; PubMed Central PMCID: PMC2230588.

7: Ocorr K, Fink M, Cammarato A, Bernstein S, Bodmer R. Semi-automated Optical Heartbeat Analysis of small hearts. J Vis Exp. 2009 Sep 16;(31). pii: 1435. doi: 10.3791/1435. PubMed PMID: 19759521; PubMed Central PMCID: PMC3150057.

8: Alayari NN, Vogler G, Taghli-Lamallem O, Ocorr K, Bodmer R, Cammarato A*. Fluorescent labeling of Drosophila heart structures. J Vis Exp. 2009 Oct 13;(32). pii: 1423. doi: 10.3791/1423. PubMed PMID: 19826399; PubMed Central PMCID: PMC3164059. (* corresponding author)

9: Cammarato A*, Craig R, Lehman W. Electron microscopy and three-dimensional reconstruction of native thin filaments reveal species-specific differences in regulatory strand densities. Biochem Biophys Res Commun. 2010 Jan 1;391(1):193-7. doi: 10.1016/j.bbrc.2009.11.030. Epub 2009 Nov 10. PubMed PMID: 19900412; PubMed Central PMCID: PMC2818542. (* corresponding author)

10: Neely GG*, Kuba K*, Cammarato A*, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010 Apr 2;141(1):142-53. doi: 10.1016/j.cell.2010.02.023. PubMed PMID: 20371351; PubMed Central PMCID: PMC2855221. (* equally contributing authors)

11: Melkani GC, Lee CF, Cammarato A, Bernstein SI. Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase. Biochem Biophys Res Commun. 2010 May 28;396(2):317-22. doi: 10.1016/j.bbrc.2010.04.090. Epub 2010 Apr 18. PubMed PMID: 20403336; PubMed Central PMCID: PMC2888609.

12: Sousa D, Cammarato A, Jang K, Graceffa P, Tobacman LS, Li XE, Lehman W. Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands. Biophys J. 2010 Aug 4;99(3):862-8. doi: 10.1016/j.bpj.2010.05.004. PubMed PMID: 20682264; PubMed Central PMCID: PMC2913205.

13: Vikhorev PG, Vikhoreva NN, Cammarato A, Sparrow JC. In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation. J Muscle Res Cell Motil. 2010 Sep;31(3):171-9. doi: 10.1007/s10974-010-9221-x. Epub 2010 Jul 24. PubMed PMID: 20658179.

14: Cammarato A, Ahrens CH, Alayari NN, Qeli E, Rucker J, Reedy MC, Zmasek CM, Gucek M, Cole RN, Van Eyk JE, Bodmer R, O'Rourke B, Bernstein SI, Foster DB. A mighty small heart: the cardiac proteome of adult Drosophila melanogaster. PLoS One. 2011 Apr 25;6(4):e18497. doi: 10.1371/journal.pone.0018497. PubMed PMID: 21541028; PubMed Central PMCID: PMC3081823.

15: Kaushik G, Fuhrmann A, Cammarato A*, Engler AJ*. In situ mechanical analysis of myofibrillar perturbation and aging on soft, bilayered Drosophila myocardium. Biophys J. 2011 Dec 7;101(11):2629-37. doi: 10.1016/j.bpj.2011.10.042. PubMed PMID: 22261050; PubMed Central PMCID: PMC3297788. (* co-corresponding authors)

16: Cammarato A, Li XE, Reedy MC, Lee CF, Lehman W, Bernstein SI. Structural basis for myopathic defects engendered by alterations in the myosin rod. J Mol Biol. 2011 Dec 9;414(4):477-84. doi: 10.1016/j.jmb.2011.10.019. Epub 2011 Oct 20. PubMed PMID: 22037585; PubMed Central PMCID: PMC3230674.

17: Wang Y, Melkani GC, Suggs JA, Melkani A, Kronert WA, Cammarato A*, Bernstein SI*. Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness. Mol Biol Cell. 2012 Jun;23(11):2057-65. doi: 10.1091/mbc.E12-02-0120. Epub 2012 Apr 11. PubMed PMID: 22496423; PubMed Central PMCID: PMC3364171. (* co-corresponding authors)

18: Xie HB, Cammarato A, Rajasekaran NS, Zhang H, Suggs JA, Lin HC, Bernstein SI, Benjamin IJ, Golic KG. The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. PLoS Genet. 2013 Jun;9(6):e1003544. doi: 10.1371/journal.pgen.1003544. Epub 2013 Jun 20. PubMed PMID: 23818860; PubMed Central PMCID: PMC3688542.

19: Viswanathan MC, Kaushik G, Engler AJ, Lehman W, Cammarato A*. A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function. Circ Res. 2014 Jan 17;114(2):e6-17. doi: 10.1161/CIRCRESAHA.114.302028. Epub 2013 Nov 12. Erratum in: Circ Res. 2014 Feb 14;114(4):e28. PubMed PMID: 24221941; PubMed Central PMCID: PMC4526186. (* corresponding author)

20: Nishimura M, Kumsta C, Kaushik G, Diop SB, Ding Y, Bisharat-Kernizan J, Catan H, Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen M, Ocorr K. A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Aging Cell. 2014 Jun;13(3):431-40. doi: 10.1111/acel.12193. Epub 2014 Jan 9. PubMed PMID: 24400780; PubMed Central PMCID: PMC4032615.

21: Viswanathan MC, Blice-Baum AC, Schmidt W, Foster DB, Cammarato A*. Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance. Front Physiol. 2015 Apr 28;6:116. doi: 10.3389/fphys.2015.00116. eCollection 2015. PubMed PMID: 25972811; PubMed Central PMCID: PMC4412121. (* corresponding author)

22: Cammarato A, Ocorr S, Ocorr K. Enhanced assessment of contractile dynamics in Drosophila hearts. Biotechniques. 2015 Feb 1;58(2):77-80. doi: 10.2144/000114255. eCollection 2015 Feb. PubMed PMID: 25652030.

23: Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A*, Engler AJ*. Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart. Sci Transl Med. 2015 Jun 17;7(292):292ra99. doi: 10.1126/scitranslmed.aaa5843. PubMed PMID: 26084806; PubMed Central PMCID: PMC4507505. (* co-corresponding authors)

24: Kooij V, Viswanathan MC, Lee DI, Rainer PP, Schmidt W, Kronert WA, Harding SE, Kass DA, Bernstein SI, Van Eyk JE, Cammarato A. Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy. Cardiovasc Res. 2016 May 15;110(2):238-48. doi: 10.1093/cvr/cvw050. Epub 2016 Mar 7. PubMed PMID: 26956799; PubMed Central PMCID: PMC4836629.

25: Viswanathan MC, Blice-Baum AC, Sang TK, Cammarato A*. Cardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function. J Cardiovasc Dev Dis. 2016 Jun;3(2). pii: 19. Epub 2016 May 24. PubMed PMID: 27500162; PubMed Central PMCID: PMC4973812. (* corresponding author)

26: Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI. A restrictive cardiomyopathy mutation in an invariant proline at the myosin head/rod junction enhances head flexibility and function, yielding muscle defects in Drosophila. J Mol Biol. 2016 Jun 5;428(11):2446-61. doi: 10.1016/j.jmb.2016.04.021. Epub 2016 Apr 20. PubMed PMID: 27107639; PubMed Central PMCID: PMC4884507.

27: Blice-Baum AC, Zambon AC, Kaushik G, Viswanathan MC, Engler AJ, Bodmer R, Cammarato A*. Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline. Aging Cell. 2016. In press. (* corresponding author)

Review Articles:

1: Taghli-Lamallem O*, Bodmer R, Chamberlain JS, Cammarato A*. Genetics and pathogenic mechanisms of cardiomyopathies in the Drosophila model. Drug Discovery Today: Disease Models. 2008 Nov 30;5(3):125-34. (* co-corresponding authors)

2: Kaushik G, Zambon AC, Fuhrmann A, Bernstein SI, Bodmer R, Engler AJ, Cammarato A*. Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. J Cell Mol Med. 2012 Aug;16(8):1656-62. doi: 10.1111/j.1582-4934.2011.01517.x. PubMed PMID: 22225769; PubMed Central PMCID: PMC3326184. (* corresponding author)

3: Kooij V, Venkatraman V, Tra J, Kirk JA, Rowell J, Blice-Baum AC, Cammarato A, Van Eyk JE. Sizing up models of heart failure: Proteomics from flies to humans. Proteomics Clin Appl. 2014 Oct;8(9-10):653-64. doi: 10.1002/prca.201300123. Epub 2014 Jun 25. PubMed PMID: 24723306; PubMed Central PMCID: PMC4282793.