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Cammarato Lab Projects

Active Projects

AFAR Research Grant

Cammarato, A., P.I.
07/01/12-06/30/14
American Federation for Aging Research

Determining and manipulating age-dependent changes in myocardial stiffness, in vivo. The specific aims of the project are: 1) Identify differences in potential collective, age-related myocardial stiffening events among multiple Drosophila control lines. We will ascertain passive mechanical differences in young vs. old fly hearts from several control strains including Oregon-R, w1118, Canton-S and GMH5-GAL4 x yw. 2) Investigate the effect of aging on passive mechanical properties of Drosophila myocardium with cardiac-specific overexpression of the transcription factor FOXO, which is known to rejuvenate cardiac performance and promote muscle proteostasis in senescent flies. 3) Employ targeted, cardiac-specific RNA interference to improve morphology, performance and mechanics of senescent hearts.

Scientist Development Grant

Cammarato, A., P.I.
07/01/10-06/30/14
American Heart Association (AHA) National Center, 10SDG4180089

Identifying and manipulating age- and mutation-dependent modifiers of cardiac function using the Drosophila model. The specific aims of the project are: 1) Identify age-related changes in cardiac expression profiles using GeneChip microarrays that represent the complete Drosophila genome. This will be done for young and old wildtype fly hearts and for the hearts of two myosin heavy chain mutants and a troponin mutant. 2) Employ RNA interference to knockdown specific cardiac transcripts to determine their role in myopathic responses to the myosin mutations.


Completed Projects

Post-doctoral Fellowship

Cammarato, A., P.I.
07/01/06-06/30/08
American Heart Association (AHA) Western States Affiliate, 0625018Y
Genetic Manipulation of Myosin and its Effect on Cardiac Performance During Aging.

The specific aims of the project were: 1) to examine the normal MHC isoform pattern during aging and the effect of genetically manipulating this pattern on cardiac performance and structure. 2) Determine the effects of two MHC point mutations, which kinetically alter the molecule in opposing directions, on cardiac function and structure during aging.

 

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