ASCEND-HF Study

This study is now closed. Thank you for your interest.

Principal Investigator: Stuart Russell, MD

Study Coordinator: Stuart Russell, MD
 
Contact Phone: (410) 955-5708

Contact email: srusse14@jhmi.edu 

Study Short title: ASCEND-HF
 
Study Long Title: Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritide in Subjects With Decompensated Heart Failure
 
IRB# NA_00010881

Funding source: Scios Inc. Johnson & Johnson
 
Summary of Trial: The primary objective of the trial is to evaluate whether treatment with nesiritide improves patient outcomes or heart failure symptoms compared with placebo when each is administered in addition to other standard therapies in subjects with acute decompensated heart failure

Inclusions:

• Age >18
• Hospitalized with acute decompensated heart failure
• Must be enrolled within 24 hours of having received IV diuretic

Exclusions:

• Subjects at high risk to develop low blood pressure or have contraindications for vasodilators
• Persistent uncontrolled high blood pressure
• Acute coronary syndrome
• Chronic obstructive lung disease
• Anemia

Clinical Trial Site:
Johns Hopkins Hospital
600 N. Wolfe St.
Baltimore, MD 21287

Compensation: No, parking passes available for return research visit at 30 days

Start date: March 2008

Anticipated End Date: End of 2010 (once 7000 subjects enrolled world-wide)