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Valproate and Neuroprotection in Aortic Surgery

This study is now closed.

Summary of Trial:	The purpose of this study is to determine if valproate, which has been demonstrated to be neuroprotective in a canine model of hypothermic circulatory arrest, can be safely used as a neuroprotective agent intraoperatively in humans.
Principal Investigators:	Drs. Guy M. McKhann and William A. Baumgartner
Study Coordinators:	Maura Grega, MSN, CCRP Email: mgrega@jhmi.edu (410) 446-6161 Kimberly Behrens, RN, BSN Email: kbehren1@jhmi.edu (410) 502-1914
Study Long Title:	Valproate And Neuroprotection in Aortic Surgery
Study Short Title:	VANAS Study
JHU eIRB Number:	NA_00016111
Funding Source:	Advanced Translational Incubator Program Grant
Inclusions:	Patients having aortic surgery, to include aortic root replacements, aortic aneurysm repair, valve sparing aortic root surgery Concomitant cardiac surgery is allowed Adult patients
Exclusions:	Patients with any abnormal liver function or thrombocytopenia prior to surgery History of a seizure disorder or who is taking anti-seizure meds Known drug allergy to valproate sodium or taking valproate now Acute stroke preoperatively Individuals taking Lamotrigine
Clinical Trial Site:	Johns Hopkins Hospital 600 North Wolfe Street, Blalock 618 Baltimore, MD 21287-4618
Start Date:	February 2009
Anticipated End Date:	N/A
Compensation for Participating:	$50

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