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Cardiovascular Disease Research

Cardiovascular disease continues to be the leading cause of death in the US. About 1,400,000 people die from cardiovascular disease annually. The American Heart Association estimates that 2,600 Americans die of cardiovascular disease every day. At Johns Hopkins, faculty with a particular interest in cardiovascular disease are approaching both primary and secondary prevention modalities in high risk populations, including families with premature coronary disease, people with hypertension and or obesity, and an urban community population. Studies range from genetic and molecular studies of the mechanisms of cardiovascular disease to studies of vascular properties, lifestyle interventions, and responsiveness to preventive pharmacotherapy. We also have a broad interest in the context in which intervention and prevention strategies are employed, including medical environments, alternative care systems in communities, and self-help. A considerable portion of our work is focused on genetic epidemiology and gene-environment interactions. Hopkins GIM brings together experts in cardiovascular and related research on the Hopkins campus, including faculty from Cardiology (Drs. Lewis Becker, Brian G. KralJeffrey Brinker, Pamela Ouyang, and Kerry J. Stewart), Critical Care Medicine and thrombosis resaerch (Dr. Nauder Faraday), Neurology (Dr. Paul Nyquist), Radiology (Dr. Elliott K. Fishman), Neuroradiology (Dr. David Yousem), Genetic epidemiology (Drs. M. Daniele Fallin and Rasika Mathias), and Endocrinology (Dr. Rita Kalyani). Drs. Linzhao Cheng and Zack Wang from the Institute for Cell Engineering are members of our research Division research team.

Information about Hopkins GIM faculty working in these research areas is provided below.

Lawrence Appel, MD, MPH
Professor of Medicine, Epidemiology, and International Health
Director, Welch Center for Prevention, Epidemiology, and Clinical Research

Research Interests: Prevention of blood pressure-related cardiovascular and kidney diseases through pharmacologic and non-pharmacologic approaches, often nutrition-based   
To see publication abstracts: PUBMED

Diane M. Becker, MPH, ScD
Professor of Medicine and Health Policy and Management
Director, The GeneSTAR Research Center (Genetic Studies of Atherosclerosis Risk)
Research Interests: Genetic epidemiology, health disparities, primary prevention, behavioral sciences, research design
To see publication abstracts: PUBMED

Lewis C. Becker, MD
Robert L. Levy Professor, Cardiology
Co-Director, Basic Research in Cardiovascular Disease and Cell Unit
Core Faculty: The GeneSTAR Research Center (use our website link here)
Robert L. Levy Professor of Cardiology
Research interests: platelet function, coronary artery imaging and perfusion genetics, transcriptomics, proteomics, and induced pluripotent cell engineering.  
To see publication abstracts: PUBMED

Daniel Brotman, MD, FACP, FSHM
Associate Professor of Medicine
Director, Johns Hopkins Hospitalist Program
Research Interests: Vascular events in hospitalized adults, circadian rhythms
To see publication abstracts: PUBMED

Lisa Cooper, MD, MPH, FACP
Professor of Medicine, Epidemiology, and Health Behavior and Society
Core Faculty, Welch Center for Prevention, Epidemiology, and Clinical Research

Director, Center to Eliminate Cardiovascular Health Disparities
Research Interests: Health disparities in CVD, spirituality, physician-patient relationship and communication
To see publication abstracts: PUBMED

Josef Coresh, MD, PhD, MHS
Professor of Epidemiology and Medicine

Director, George W. Comstock Center for Public Health Research and Prevention (GWCC)
Core Faculty,Welch Center for Prevention, Epidemiology, and Clinical Research
Director, CVD Epidemiology Track
Director, NHLBI Training Grant (T32) in Cardiovascular Epidemiology
Principal Investigator, the ARIC Study
Research Interests: Epidemiology of cardiovascular disease and chronic kidney disease, genetic and molecular epidemiology, epidemiologic methods
To see publication abstracts:  PUBMED

Margaret Daniele Fallin, PhD
Professor and Chair of Mental Health, JHBSPH
Director, Wendy Klag Center for Autism and Developmental Disabilities
Research interests: Application of genetic epidemiology methods to studies of neuropsychiatric disorders, genetic predisposition to features affecting aging populations, methods for genetic analysis of population data
To see publication abstracts:  PUBMED

Nauder Faraday, MD, MPH
Professor, Critical Care Medicine
Director: GeneSTAR Thrombosis and Hemostatis Unit
Core Faculty: GeneSTAR ResearchProgram
Research Interests: platelet biology, platelet leukocyte interactions and CVD, genetics and transriptomics, proteomics


Eliseo Guallar, MD, DrPH
Professor of Epidemiology and Medicine
Core Faculty, Welch Center for Prevention, Epidemiology, and Clinical Research
Research Interests: Epidemiology of heavy metal exposure in related to cardiovascular disease, meta-analytic methods, advanced epidemiologic methods
To see publication abstracts: PUBMED

Michael J. Klag, MD, MPH
Professor of Epidemiology and Medicine
Dean, Johns Hopkins Bloomberg School of Public Health        

Core Faculty, Welch Center for Prevention, Epidemiology and Clinical Research       
Research Interests: Cardiovascular and renal epidemiology
To see publication abstracts: PUBMED

Brian G. Kral, MD, MPH
Assistant Professor, Cardiology
Director, GeneSTAR Clinical Studies Unit
Core Faculty: GeneSTAR Research Program
Research Interests: Coronary artery imaging, coronary plaque characteristics, familial clustered coronary disease. Primary prevention monocyte activity and coronary  plaque

Rasika Mathias, ScD
Associate Professor and Epidemiology
Director: GeneSTAR Genetic Analysis Unit
Core Faculty: The GeneSTAR Research Center
Research Interests: genetic epidemiology, platelet genetics, family-based genetics, whole exome and whole genome sequencing methods

Edgar (Pete) Miller, MD, PhD
Professor of Medicine and Epidemiology
Core Faculty, Welch Center for Prevention, Epidemiology, and Clinical Research
Research Interests: Hypertension, CVD prevention, weight reduction
To see publication abstracts: PUBMED

Paul Nyquist MD, MPH
Associate Professor, Neurology
Director: Neurology and Stroke Research
Core Faculty: GeneSTAR Research Center
Reseearch Interests: Brain MRO, white matter disease, primary prevention, small vessel disease, primary prevention

Rehan Qayyum, MD
Assistant Professor of Medicine
Research Interests: Meta-analysis in diabetes and CVD treatment
To see publication abstracts: PUBMED

Dhananjay (Jay) Vaidya, MBBS, PhD, MPH
Associate Professor of Medicine
Co-Director; GeneSTAR Research Center
Director: GeneSTAR Statistical Analysis Unit
Research Interests: Statistics, vascular properties, gender differences and hormonal influences, randomized clinical trials, small vessel cerebrovascular disease

To see publication abstracts: PUBMED

Lisa R. Yanek, MPH
Assistant Professor, Medicine
Director; GeneSTAR National Consortia Analysis Center
Core Faculty: GeneSTAR Research Program
Research interests: methods for analysis of whole genome sequencing, GWAS, exome sequencing, bioinformatics and database curating

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