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Cardiovascular Disease Research

Cardiovascular disease continues to be the leading cause of death in the US. About 1,400,000 people die from cardiovascular disease annually. The American Heart Association estimates that 2,600 Americans die of cardiovascular disease every day. At Johns Hopkins, faculty with a particular interest in cardiovascular disease are approaching both primary and secondary prevention modalities in high risk populations, including families with premature coronary disease, people with hypertension and or obesity, and an urban community population. Studies range from genetic and molecular studies of the mechanisms of cardiovascular disease to studies of vascular properties, lifestyle interventions, and responsiveness to preventive pharmacotherapy. We also have a broad interest in the context in which intervention and prevention strategies are employed, including medical environments, alternative care systems in communities, and self-help. A considerable portion of our work is focused on genetic epidemiology and gene-environment interactions. Hopkins GIM brings together experts in cardiovascular and related research on the Hopkins campus, including faculty from Cardiology (Drs. Lewis Becker, Brian G. KralJeffrey Brinker, Pamela Ouyang, and Kerry J. Stewart), Critical Care Medicine and thrombosis research (Dr. Nauder Faraday), Neurology (Dr. Paul Nyquist), Radiology (Dr. Elliott K. Fishman), Neuroradiology (Dr. David Yousem), Genetic epidemiology (Drs. M. Daniele Fallin and Rasika Mathias), and Endocrinology (Dr. Rita Kalyani). Drs. Linzhao Cheng and Zack Wang from the Institute for Cell Engineering are members of our research Division research team.

Information about Hopkins GIM faculty working in these research areas is provided below.

Photo of Dr. Lawrence J. Appel, M.D., M.P.H.

Appel, Lawrence J., M.D., M.P.H.

Professor of Medicine
Director, Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University
The C. David Molina, M.D., M.P.H. Professor of Medicine, Epidemiology and International Health
Research Interests: Hypertension, Cardiovascular and Kidney Disease Prevention, Lifestyle Modification
 
Photo of Dr. Diane M. Becker, M.P.H., Sc.D.

Becker, Diane M., M.P.H., Sc.D.

Professor of Medicine
Director, GeneSTAR Research Program
Research Interests: Health disparities, Social/behavioral science, Community based CVD prevention, Molecular and physiologic aspects of CVD risk, Genetics/epidemiology of premature cardiovascular disease (CVD)
 
Photo of Dr. Lewis C Becker, M.D.

Becker, Lewis C, M.D.

Professor of Medicine
Joint Appointment in Radiology and Radiological Science
Research Interests: Pathogenesis of post-ischemic myocardial inflammation and role in reperfusion injury, Regulation of proinflammatory genes in reperfused myocardium, Effects of mental stress on the heart, Genetics of premature coronary artery disease (GeneSTAR)
 
Photo of Dr. Daniel Joseph Brotman, M.D.

Brotman, Daniel Joseph, M.D.

Professor of Medicine
Director, Hospitalist Program, The Johns Hopkins Hospital
Research Interests: Hospital medicine, Perioperative medicine, Internal medicine
 
Photo of Dr. Lisa Angeline Cooper, M.D., M.P.H.

Cooper, Lisa Angeline, M.D., M.P.H.

Professor of Medicine
Bloomberg Distinguished Professor, Health and Healthcare Equity
James F. Fries Professor of Medicine
Director, Johns Hopkins Center to Eliminate Cardiovascular Health Disparities
Core Faculty, Welch Center for Prevention, Epidemiology, and Clinical Research
Core Faculty, Armstrong Institute for Patient Safety and Quality
Vice President, Health Care Equity for Johns Hopkins Medicine
Research Interests: Race/ethnic health disparities, Patient-centered care, Patient-Physician relationship and communication
 
Photo of Dr. Josef Coresh, M.D., Ph.D.

Coresh, Josef, M.D., Ph.D.

Joint Appointment in Medicine
Director, Cardiovascular Epidemiology Training Program
Director, George W. Comstock Center for Public Health Research and Prevention
Research Interests: Epidemiology, Cardiovascular epidemiology, Vascular diseases, Kidney diseases, Genetic epidemiology
 
Photo of Dr. Margaret Daniele Fallin, Ph.D.

Fallin, Margaret Daniele, Ph.D.

Joint Appointment in Medicine
Joint Appointment in Psychiatry and Behavioral Sciences
Sylvia and Harold Halpert Professor and Chair, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health
Director, Wendy Klag Center for Autism & Developmental Disabilities
Co-Director, Genetics Core, Claude D. Pepper Older Americans Independence Center
Research Interests: Epidemiology, Genetics, Epigenetics, Genetic epidemiology, Neuropsychiatric disorders, Mental health, Development, Single-nucleotide polymorphism (SNP), Autism, Alzheimer's disease, Schizophrenia, Bipolar disorder
 
Photo of Dr. Nauder Faraday, M.D.

Faraday, Nauder, M.D.

Professor of Anesthesiology and Critical Care Medicine
Assistant Professor of Surgery
Professor of Medicine
Director, Perioperative Genomic and Translational Research, Department of Anesthesiology and Critical Care Medicine
Director, Perioperative Hemostasis and Thrombosis Research Laboratory, Department of Anesthesiology and Critical Care Medicine
Co-Director, Cardiac Surgical Intensive Care
Research Interests: Genetic determinants of complications after surgery
 
Photo of Dr. Eliseo Guallar, M.D., M.P.H.

Guallar, Eliseo, M.D., M.P.H.

Joint Appointment in Medicine
Research Interests: Cardiovascular disease epidemiology, Epidemiologic methods, Polyunsaturated fatty acids, Fish oils, Heavy metals, Meta-analysis
 
Photo of Dr. Michael J. Klag, M.D., M.P.H.

Klag, Michael J., M.D., M.P.H.

Professor of Medicine
Dean, Johns Hopkins Bloomberg School of Public Health
Research Interests: Hypertension, Renal failure, Precursors Study, Kidney disease, Cardiovascular, Epidemiology, Genetic markers, Health policy and management
 
Photo of Dr. Brian Gustav Kral, M.D., M.P.H.

Kral, Brian Gustav, M.D., M.P.H.

Assistant Professor of Medicine
Assistant Professor of Radiology and Radiological Science
Research Interests: Stress myocardial perfusion imaging, Genetic and biological mechanisms of premature coronary artery disease (Johns Hopkins GeneSTAR), Noninvasive imaging of coronary atherosclerosis, Cardiovascular and genetic epidemiology, Association of mental stress and cardiovascular disease
 
Photo of Dr. Rasika Ann Mathias, Sc.D.

Mathias, Rasika Ann, Sc.D.

Associate Professor of Medicine
Research Interests: Genetic epidemiology with emphasis on cardiovascular/asthma/lung disease and other chronic disease processes.
 
Photo of Dr. Edgar Raymond Miller, III, M.D., Ph.D.

Miller, Edgar Raymond, M.D., Ph.D. III

Professor of Medicine
Deputy Director - Johns Hopkins Institute for Clinical and Translational Science, Research Clinical, Education, Training and Career Development Program
Director Clinical Research Scholars Program (KL-2), Johns Hopkins Institute for Clinical and Translational Research
Research Interests: Non-pharmacologic therapies, Hypertension, Antioxidants
 
Photo of Dr. Dhananjay Madhukar Vaidya, M.B.B.S., M.P.H., Ph.D.

Vaidya, Dhananjay Madhukar, M.B.B.S., M.P.H., Ph.D.

Associate Professor of Medicine
Research Interests: Mechanisms of vascular dysfunction, Assessment of cardiovascular risk factors
 
Photo of Dr. Lisa Renee Yanek, M.P.H.

Yanek, Lisa Renee, M.P.H.

Assistant Professor of Medicine
Research Interests: Cardiovascular disease in families and risk factor modification
 

Rehan Qayyum, MD, MHS

Assistant Professor of Medicine

Research Interests: Platelet biology, hemostasis and thrombosis, pharmacogenomics of anti-platelet agents, genetic epidemiology, systematic reviews, meta-analysis.
To see publication abstracts: PUBMED

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