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Geriatric Medicine & Gerontology
 

Sean X. Leng, M.D. Ph.D

Academic Appointment(s):

  • Assistant Professor

Division Title(s):

  • Full-time faculty member

Research Interests:

  • Inflammation, Immunity, and Frailty
  • International collaborative development of geriatrics program

Clinical Interests:

  • Acute and subacute geriatrics care
  • General Geriatrics

Selected publications:

  • Leng X and Wilson VG. Genetically defined NLS of BPV-1 E1 protein is necessary and sufficient for the nuclear localization of E1 fusion proteins. J. Gen. Virol. 1994; 75:2463-67
  • Leng X, Ludes-Meyers JH, and Wilson VG. Isolation of an amino-terminal region of BPV-1 E1 protein that retains origin binding and E2 interaction capacity. J Virol. 1997;71(1):848-52
  • Leng SX and Elias JE. Interleukin-11 inhibits macrophage interleukin-12 production. J. Immunol. 1997; 159:2161-68
  • Leng SX and Elias JE. Interleukin-11. Int J Biochem Cell Biol. 1997; 29: 1059-1062.
  • Leng SX, Erim E, McShine E, Bloom PA, and Kotler DP. Influence of medical illness on body composition and quality of life in geriatric outpatients: a pilot study. J. Am. Geri. Soc. 2000; 48 (12):1737-38
  • Leng SX, Chaves P, Koenig K, and Walston J. Serum IL-6 and hemoglobin as physiologic correlates in the geriatric syndrome of frailty. J. Am. Geri. Soc. 2002; 50:1268-1271
  • Leng SX, Cappola A, Anderson R, Blackman M, Koenig K, Yang H, Blair M, and Walston J. Serum levels of IGF-1 and DHEA-S and their relationships with serum IL-6 in the geriatric syndrome of frailty. Aging Clin. Exp. Res. 2004; 16:153-57
  • Leng SX, Yang H, and Walston J. Decreased cell proliferation and altered cytokine production in frail older adults. Aging Clin. Exp. Res. 2004; 16:249-52
  • Leng SX, Xue Q, Huang Y, Semba R, Chaves P, Bandeen-Roche K, Fried L, and Walston J. Total and differential white blood cell counts and their associations with circulating IL-6 levels in community-dwelling older women. J. Gerontol. Med. Sci. 2005; 60A:195-199
  • Leng SX, Xue Q, Huang Y, Ferrucci L, Fried L, and Walston J. Baseline total and specific differential white blood cell counts and 5-year all-cause mortality in community-dwelling older women. Exp Gerontol. 2005; 40:982-7.
  • Leng SX, Q Xue, J Tian, J Walston, and L Fried. 2007. Inflammation and frailty in older women. J. Am. Geri. Soc. (in press)

Education/Training:

  • M.D.: Jiangxi Medical College, the People’s Republic of China
  • Ph.D.: Texas A&M University Health Sciences Center, College Station, TX
  • Internship/Residency: Peking Union Medical College Hospital, Beijing, China and St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY
  • Fellowship: Johns Hopkins University School of Medicine, Baltimore, MD

Click here to send an email to Dr. Leng.

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