Academic Appointment(s)
- Associate Professor
Division Title(s):
- Co-Director, Fellowship Training Program
Research Interests:
- The role(s) of SIBLING gene family members in tumor progression.
- Biology of aging
Selected publications:
- Fedarko, N.S., Fohr, B., Young, M.F., Robey, P.G., and L.W. Fisher. Factor H binding to bone sialoprotein and osteopontin enables molecular cloaking of tumor cells from complement-mediated attack. J. Biol. Chem. 2000; 275: 16666-16672.
- Fisher, L.W., Torchia, D.A., Fohr, B., Young, M.F., and N.S.Fedarko. Flexible structures of SIBLING proteins, bone sialoprotein and osteopontin. Biochem. Bophys. Res. Comm. 2001; 280:460-465.
- Fedarko, N.S., Jain, A., Karadag, A., Van Eman, M., and L.W. Fisher. Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate and lung cancer. Clin. Cancer Res. 2001; 7:4060-4066.
- Jain, A., Karadag, A., Fohr , B., Fisher, L.W., and N.S. Fedarko. Three Small Integrin Binding LIgands N-linked Glycoproteins (SIBLINGs) enhance Factor H’s cofactor activity enabling MCP-like cellular evasion of complement-mediated attack. J. Biol. Chem. 2002; 277:13700-13708.
- Grzesik, W.J., Frazier, C.R., Shapiro, J.R., Sponsellor, P.D., Robey, P.G., and N.S. Fedarko. Age-related changes in human bone proteoglycan structure: impact of osteogenesis imperfecta. J. Biol. Chem. 2002; 277:43638-47.
- Fedarko, N.S. Aging and protein expression. J. Musculoskel. Neuron. Interact. 2002; 2(6):584-589.
- Fisher, L., and N.S. Fedarko. Six genes expressed in bones and teeth constitute the current members of the SIBLING family of proteins. Connective Tissue Res. 2003; 44:1-8.
- Fedarko, N.S., Jain, A., Bianco, P., Ogbureke, K.U.E., Karadag, A., and L.W. Fisher. Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases. FASEB J. 2004; 18:734-736.
- Fisher, L.W., Jain, A., Tayback, M., and N.S. Fedarko. Small Integrin Binding Ligand N-Linked Glycoprotein (SIBLING) gene family expression in different cancers. Clin. Cancer Res. 2004; 10(24): 10:8501-8511.
- Xu, K.Y., E. Takimoto, and N.S. Fedarko. Activation of (Na(+)+K(+))-ATPase induces positive inotropy in intact mouse heart in vivo. Biochem Biophys Res Commun, 2006; 349(2): p. 582-7.
Education/Training:
- Ph.D.: University of Illinois, Champaign-Urbana
- Fellowship: National Institutes of Health, Bethesda, MD
Click here to send an email to Dr. Fedarko.
