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Qian-Li Xue, PhD

_Xue_Qian_LiPhone number:  410-502-7808


Academic Appointment(s):

  • Director of Biostatistics, Division of Geriatric Medicine and Gerontology and Center on Aging and Health
  • Assistant Professor -Department of Medicine, Biostatistics, Epidemiology and Center on Aging and Health, Johns Hopkins Medical Institutions

Interests:  Biostatistics, Epidemiology of Aging, Frailty, Sarcopenia

Research Interests:

My research interest focuses on the natural history of frailty and its phenotypic components including sarcopenia and low physical activity. As a co-investigator of the Women’s Health and Aging Studies since 2001, I’ve been spearheading the analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation, and micronutrient deficiencies to the development and progression of frailty. This work is providing a critical foundation for the next generation of research to delineate the synergistic effects of dysregulation in multiple biological systems on frailty. It promises to provide new biological insights and, thereby, inform the development of new interventions to treat the concurrent multisystem changes that occur in accelerated aging. In addition, I have recently developed an interest in methods to study the clinical relevance of aging-related loss of muscle mass and strength in older adults (referred to as sarcopenia), with the goal of establishing the prognostic value of intra-person variability and change in muscle mass and strength for long-term health outcomes.

Selected publications:

Xue QL, Bandeen-Roche K, Mielenz, TJ, Seplaki CL, Szanton SL, Thorpe RJ, Kalyani RR, Chaves PH, Dam TT, Ornstein K, RoyChoudhury A, Yao WL, Fried LP. Patterns of 12-Year Change in Physical Activity in Community-Dwelling Older Women: Can Modest Levels of Physical Activity Help Older Women Live Longer? Am J Epidemiol. 2012; DOI: 10.1093/aje/kws125.

Szanton SL, Thorpe RJ, Boyd C, Tanner EK, Leff B, Agree E, Xue QL, Allen JK, Seplaki CL, Weiss C, Guralnik JM, Gitlin LN. Community aging in place, advancing better living for elders: a bio-behavioral-environmental intervention to improve function and health-related quality of life in disabled older adults. J Am Geriatr Soc. 2011 Dec;59(12):2314-20. PMID: 22091738

Yao X, Hamilton R, Weng N-P, Xue QL, Bream JH, Tian J, Yeh S-H, Resnick B, Xu XY, Walston JD, Fried LP, Leng SX. Frailty is associated with poor vaccine-induced antibody response and increased influenza infection in community-dwelling older adults. Vaccine. 2011 Jul 12;29(31):5015-21. PMID: 21565245

Xue QL, Walston JD, Fried LP, Beamer BA. Rate of decline in grip strength predicts the risk of falling, physical disability, and frailty: The Women’s Health and Aging Study. Arch Intern Med. 2011 Jun;171(12): 1119:1121. PMID: 21709116

Xue QL. The Frailty Syndrome: Definition and Natural History. Clin in Geriatr Med. 2011 Feb;27(1):1-15. PMID: 21093718

Xue QL, Beamer BA, Chaves PHM, Guralnik JM, Fried LP. Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: The Women’s Health and Aging Study II. J Am Geriatr Soc. 2010 Nov;58(11):2076-84. PMID: 21054287

Tan EJ, Tanner EK, Seeman TE, Xue QL, Rebok GW, Frick KD, Carlson MC, Wang T, Piferi RL, McGill S, Whitfield KE, Fried LP. Marketing public health through older adult volunteering: Experience Corps as a social marketing intervention. Am J Public Health. 2010 Apr;100(4):727-34. PMID: 20167888

Rosenberg PB, Mielke MM, Xue QL, Carlson MC. Depressive Symptoms Predict Incident Cognitive Impairment in Cognitive Healthy Older Women. Am J Geriatr Psychiatry. 2010 Mar;18(3):204-11. PMID: 20224517

Boyd CM, Ricks M, Fried LP, Guralnik JM, Xue QL, Xia J, Bandeen-Roche K. Functional Decline and Recovery of Activities of Daily Living in Hospitalized, Disabled Older Women: The Women’s Health and Aging Study I. J Am Geriatr Soc. 2009 Oct;57(10):1757-66. PMID: 19694869  

Fried LP, Xue QL, Cappola A, Chaves PHM, Ferrucci L, Leng S, Semba RD, Varadhan R, Walston JD, Bandeen-Roche K. Multisystem physiologic abnormalities in frailty: evidence for nonlinear system biology at the macro level. J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1049-57. PMID: 19567825

Deal JA, Carlson MC, Xue QL, Fried LP, Chaves PH.  Anemia and 9-Year Domain-Specific Cognitive Decline in Community-Dwelling Older Women: The Women's Health and Aging Study II. J Am Geriatr Soc. 2009 Sep;57(9):1604-11. PMID: 19682133

Leng SX, Xue QL, Tian J, Huang Y, Yeh S-H, Fried LP. Associations of Neutrophil and Monocyte Counts with Frailty in Community-Dwelling Disabled Older Women: Results from the Women's Health and Aging Study I. Exp Gerontol. 2009 Aug; 44(8):511-6. PMID: 19457449

Stewart R, Xue QL, Masaki K, Petrovitch H, Ross GW, White LR, Launer LJ. Change in blood pressure and incident dementia: a 32-year prospective study. Hypertension. 2009 Aug; 54(2):233-40. PMID: 19564551

Thorpe RJ, Weiss CO, Xue QL, Fried LP. Transitions among disability levels or death in African American and white older women. J Gerontol A Biol Sci Med Sci. 2009 Jun; 64(6):670-4. PMID: 19228790 

Blaum CS, Xue QL, Tian J, Semba RD, Fried LP, Walston JD. Is hyperglycemia associated with frailty status in older women? J Am Geriatr Soc. 2009 May; 57(5):840-7. PMID: 19484839

Cappola AR, Xue QL, Fried LP. Multiple Hormonal Deficiencies in Anabolic Hormones Are Found in Frail Older Women: The Women's Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2009 Feb; 64(2):243-8. PMID: 19182229

Carlson MC, Xue QL, Zhou J, Fried LP. Declines and deficits in executive function precede those in memory in high-functioning older women: The Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):110-7. PMID: 19182230

Varadhan R, Seplaki CS, Xue QL, Bandeen-Roche K., Fried LP. Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty. Mech Ageing Dev. 2008; 129(11):666-70. PMID: 18938195

Xue QL, Bandeen-Roche K, Zhou J, Varadhan R, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008; 63(9): 984–990. PMID: 18840805

Xue QL, Fried LP, Glass TA, Laffan AM, Chaves PHM. Life-Space Constriction, Development of Frailty, and the Competing Risk of Mortality: The Women’s Health and Aging Study I. Am J Epidemiol. 2008; 167(2):240-48. PMID: 17906296

Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc. 2007; 55(6):864-71. PMID: 17537086

Tan EJ, Xue QL, Li T, Carlson MC, Fried LP. Volunteering: a physical activity intervention for older adults - The Experience Corps Program in Baltimore. J Urban Health. 2006; 83(5):954-69. PMID: 16763775

Lin SM, Xue QL, Simonsick EM, Tian J, Bandeen-Roche K, Fried LP, Bathon JM, Transitions to mobility difficulty associated with lower extremity osteoarthritis (oa) in high functioning older women:  longitudinal data from the Women’s Health and Aging Study II. Arthritis Rheum. 2006; 55(2):256-63. PMID: 16583416

Cappola AR, Xue QL, Walston JD, Leng SX, Ferrucci L, Guralnik J, Fried LP, DHEAS levels and mortality in disabled older women: The Women's Health and Aging Study I. J Gerontol A Biol Sci Med Sci. 2006;61(9):957-62. PMID: 16960027

Bandeen-Roche, K, Xue, QL, Ferrucci, L, Walston, J, Guralnik, JM, Fried, LP, Phenotype of Frailty: characterization in the Women’s Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2006; 61(3):262-6. PMID: 16567375

Walston, J., Xue, QL, Semba, RD, Ferrucci, L, Cappola, AR, Ricks, M, Guralnik, J, Fried, LP, Serum antioxidants, inflammation, and mortality in older women. Am J Epidemiol. 2006; 163(1):18-26. PMID: 16306311

Stewart, R, Masaki, K., Xue, QL., Peila, R., Petrovitch, H, White, L.R., and Launer, L.J., A 32-year prospective study of change in body weight and incident dementia. The Honolulu-Asia Aging Study. Arch Neurol. 2005; 62(1):55-60. PMID: 15642850

Blaum CS, Xue QL, Michelon E, Semba RD, and Fried LP. The association of obesity and the frailty syndrome in older women. J Am Geriatr Soc. 2005; 53(6):927-34. PMID: 15935013

Boyd C, Xue QL, Guralnik JM, Fried LP. Hospitalization and development of dependence in activities of daily living in a cohort of disabled older women: The Women's Health and Aging Study I. J Gerontol A Biol Sci Med Sci. 2005; 60(7):888-93. PMID: 16079213

Boyd C, Xue QL, Simpson, CF, Guralnik, JM, Fried, LP. Frailty, hospitalization and progression of disability in a cohort of disabled older women: The Women’s Health and Aging Study I. Am J Med. 2005; 118(11):1225-31. PMID: 16271906

Chaves, PHM, Xue, QL, Guralnik, JM, Ferrucci, L, Volpato, S, Fried, LP, What constitutes normal hemoglobin concentration in community-dwelling disabled older women? J Am Geriatr Soc. 2004; 52:1-6. PMID: 15507056

Cappola, AR, Xue, QL, Ferucci, L, Guralnik, JM, Volpato, S, and Fried, LP, Insulin-Like Growth Factor –1 and Interleukin-6 Contribute to disability and mortality in older women. J Clin Endocrinol Metab. 2003; 88(5):2019-2025. PMID: 12727948

Xue, QL, Bandeen-Roche, K, Combining complete multivariate outcomes with incomplete covariate information: a latent class approach. Biometrics. 2002; 58: 66-76. PMID: 11890305


  • PhD - The Johns Hopkins University; Baltimore, Maryland
  • MS -  Humboldt State University; Arcata, California
  • BS -  Shanghai Fisheries University; Shanghai, China

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