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Phone number: 410-550-9941
Interests: anemia associated with inflammation, chronic disease states and aging
Schools\degrees: University of Maryland Baltimore County: B.S.; Oregon Health Sciences University, Ph.D.
Training: Fellowship, Children’s Hospital Boston/Harvard Medical School
Research summary: The Roy laboratory aims to improve the quality of medical care for older adults by developing better methods for the assessment, diagnosis and treatment of anemia in the elderly or individuals with inflammatory disease. We use mouse models, in vitro erythroid differentiation models and population-based studies to accomplish these goals.
Roy CN, Mak HH, Akpan I, Losyev G, Zurakowski D, and Andrews NC. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood, 2007; 109(9):4038-4044.
Tanaka T, Roy CN, Yao W, Matteini A, Semba RD, Arking D, Walston JD, Fried LP, Singleton A, Guralnik J, Abecasis GR, Bandinelli S, Longo DL, and Ferrucci L.
A Genome-Wide Association Analysis of Serum Iron Concentrations. Blood, 2010;115(1):94-6.
Semba RD, Patel KV, Ferrucci L, Sun K, Roy CN, Guralnik JM, and Fried LP. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women’s Health and Aging Study I. Clinical Nutrition 2010; 29(5):600-604.
Gardenghi, S, Ramos, P, Marongiu, MF, Melchiori, L, Breda, L, Guy, E, Muirhead, K, Rao, N, Roy, CN, Andrews, NC, et al. 2010. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemic mice. J Clin Invest. 2010; 120(12):4466-77.
Roy, CN. Anemia of inflammation. Hematology Am Soc Hematol Educ Program. 2010;30:276-280.
Roy, CN. Anemia in frailty. Clin Geriatr Med 2011; 27:67-78.
Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood 2011 (in press).
Portugal S, Carret C, Recker M, Armitage A, Gonçalves L, Epiphanio S, Sullivan D, Roy C, Newbold CI, Drakesmith H, Mota MM. Host-mediated regulation of superinfection in malaria. Nature Medicine 2011 (in press).