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Biology of Healthy Aging Program

Studies within this group range from molecular and cellular to genetic and laboratory animal-based approaches targeted to understanding the mechanisms, risk factors, and pathophysiology of aging-related changes in health, function, and quality of life.

In addition, the faculty and staff involved in this interdisciplinary program has considerable expertise in the development of clinical translational studies in human populations, epidemiological studies in populations of older adults, and in clinical intervention trials.

The major aims of this group are to:

  1. Investigate etiologies for age-related activation in inflammatory and renin-angiotensin system pathways and their consequences on the development of frailty, sarcopenia, cognitive decline, osteopenia, and other chronic diseases of older adults. 
  2. Develop treatments that focus on inflammation and angiotensin system activation and their consequences
  3. Investigate the viral-related causes and treatments for immunosenescence in older adults, and develop treatments for these etiologies.
  4. Develop novel vaccination strategies for frail older adults for influenza and CMV. 
  5. Study the etiologies and consequences of aging-related changes in mitochondria on health and well being.
  6. Develop and validate physiotypes of frailty and robust health in older adults by integrating genetic, cellular, and clinical level phenomena into integrative biological models
  7. Translate novel aging-related biological findings into diagnostic tests, novel treatments, and preventive strategies that will help to optimize quality of life and healthy aging.

Our Faculty

Photo of Dr. Peter Magdy Abadir, M.D.

Abadir, Peter Magdy, M.D.

Associate Professor of Medicine
 
Photo of Dr. Neal S. Fedarko, Ph.D.

Fedarko, Neal S., Ph.D.

Professor of Medicine
Director, Clinical Research Unit Core Laboratory, Institute for Clinical & Translational Research
Director, Translational Research Training Program in Gerontology and Geriatrics
Co-Director, Biology of Healthy Aging Program, Johns Hopkins School of Medicine
 
Photo of Dr. Sean Xiao Leng, M.D., Ph.D.

Leng, Sean Xiao, M.D., Ph.D.

Associate Professor of Medicine
 
Photo of Dr. Jeremy David Walston, M.D.

Walston, Jeremy David, M.D.

Professor of Medicine
Co-Director, Biology of Healthy Aging Program, Division of Geriatric Medicine and Gerontology
Deputy Director, Division of Geriatric Medicine and Gerontology
Raymond and Anna Lublin Professor of Geriatric Medicine