Penno, Margaret B., Ph.D.

Associate Professor, Departments of Medicine, Oncology, and Pharmacology
B.S., Pennsylvania State University, 1977
Ph.D., Pennsylvania State University, 1982 

Main Interests:

Cellular adhesion and movement on basement membrane matrices is key to many biological responses. My research interest is to discover how cellular movement is enhanced or inhibited by interactions between cell surface adhesion molecules and their ligands. Model systems with cultured cells in various chambers are used to test theories of tumor cell metastasis and other pathologies. The Cell Center of the Genetics Resources Core Facility that I direct provides further expertise through the coordinated efforts of a group of cell culture specialists.

Research Interests:

• Cellular adhesion and chemotaxis
• Cellular invasion of the basement membrane
• Cell surface adhesion molecules
• Cell Culture
• Link:
  BioTechnical Institute of Maryland, Inc. 

Educational Activities:

• Director, Annual Cell Culture Workshop
• Director, "Positive Laboratory Practices" Lecture Series
• Lecturer, BioTechnical Institute of Maryland, Inc.
• Thesis Committees, Pharmacology and Molecular Sciences

 Recognition and Leadership Roles:

• Director, Cell Center of the Genetics Resources Core Facility
• Founder, Chairman of the Board, BioTechnical Institute of Maryland, Inc.
• Chair, Institutional grant review committee 

Publications:

• Fridman R, Scott AF, Muller D, Reich R, and Penno MB: The role of cell adhesion and migration in the In vitro invasiveness of mouse adrenal carcinoma cells. Invasion and Metastasis 10:208-224. , 1990.  Abstract
• Penno MB and De Maio A: A murine model for evaluating metastatic potential: characterization of a 90-110-kDa metastasis-binding protein. Exper. Geront. 27: 493-501, 1992. Abstract
• Jiang MS, Passaniti A, Penno MB, and Hart GW: Adrenal carcinoma tumor progression and penultimate cell surface oligosaccharides. Cancer Research 52:2222-2227, 1992. Abstract
• Guarnieri FG, Arterburn LM, Penno MB, Cha Y, and August TA: The motif Tyr-X-X-hydrophobic residue mediates lysosomal membrane targeting of lysosome-associated membrane protein 1. J. Biol. Chem. 268:1941-1946, 1993. Abstract
• Penno MB, August TA, Baylin S, Mabry L, Linnoila RI, Lee V, Croteau D, Yang XL and Rosatta C: Expression of CD44 in human lung tumors. Cancer Research 54: 1381-1387, 1994. Abstract
• Penno MB, Askin FB, Ma H, Carbone M, Vargas MP and Pass HI: High CD44 Expression on Human Mesotheliomas Mediates Association with Hyaluronan. The Cancer Journal 1: 196-203, 1995. Abstract
• McKee CM, Penno MB, Cowman M, Burdick MD, Strieter RM, and Bao C: Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J. Clinical Investigation 98: 2403-2413, 1996. Abstract
• Bozarth JM, Penno MB, and Mousa SA: An improved method for cellular migration: Role of aVb3 integrin in endothelial and smooth muscle cell migration. Methods in Cell Science 19: 179-187, 1997.

Book Chapters:

Penno MB: CD44, hyaluronan, and lung cancers. In Cell Adhesion Molecules and matrix proteins: Role in health and diseases. Mousa S (ed), Springer-Verlag and Landes Co, Austin, 1998.

Penno MB, Krueger M, and Ray T: Cryopreservation of human blood for B-cell immortalization. In Cell and Tissue Culture for Medical Research. Doyle A and Griffiths J (eds), J. Wiley and Sons, New York, pp 179-186, 2000. 

Contact Information:

Margaret B. Penno, PhD

Johns Hopkins University School of Medicine
Institute of Genetic Medicine
600 N. Wolfe Street
Blalock Building, Room 1036
Baltimore, Maryland 21287-3914
Phone: (410) 614-0060
Fax: (410) 614-8841
E-Mail: penno@jhmi.edu