Migeon, Barbara R., M.D.

Education:

B.A., Smith College
M.D., University of Buffalo
Resident in Pediatrics, Johns Hopkins University
Fellow in Endocrinology, Harvard University
Fellow in Genetics, Johns Hopkins University
  
Main Interests:

I am interested in the mechanisms responsible for X chromosome dosage compensation in human females. My research concerns not only the molecular basis for the single active X, but also the genetic consequences (cellular mosaicism, cell selection). I am also studying the effect of mosaicism on the phenotype and health of women.

Research Interests:

• Molecular basis of X chromosome inactivation
• Genomic imprinting in human cells
• Relevance to human disease
• Sex determination 

Educational Activities:

• Founding Director, Predoctoral Training Program in Human Genetics, 1979-1989
• Preceptor, Predoctoral Training Program in Human Genetics 1979-
• Member, University Wide Committee for Human Genetics, 1979 -
• Co-Director, Human Genetics course for medical students, 1974-1980
• Director, Human Genetics course for graduate students in the Predoctoral Training Program in Human Genetics, 1980-1989

Recognition and Leadership Roles:

• Member, NIH Study Sections: The Genetic Study 1974-75, The Mammalian Genetics Study Section 1975-77, The Genome Study Section 1991-1993; The Molecular Genetics Study Section, Breast Cancer Research Program (Univ of Cal) 1995-1998
• Member, Board of Directors, American Society of Human Genetics, 1977-1980.
• Past- Member, Editorial boards: Trends in Genetics, Cancer Research, Cytogenetics & Cell Genetics 

Publications:

• Wolf SF, Migeon BR: Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes. Nature 314: 467-469, 1985.
• Kaslow DC, Migeon BR: DNA methylation stabilizes X chromosome inactivation in eutherians, but not in marsupials: evidence for multi-step maintenance of mammalian X dosage compensation. Proc Natl Acad Sci USA 846210-6214, 1987.
• Driscoll DJ, Migeon BR: Sex differences in methylation of single copy genes in meiotic germ cells: implications for X chromosome inactivation, parental imprinting and origin of CpG mutations. Somat Cell Mol Genet 16: 267-282, 1990.
• Migeon BR, Luo S, Stasiowski BA, Jani M, Axelman J, Van Dyke D, Weiss L, Jacobs PA, Yang-Feng TL, Wiley J: Deficient transcription of XIST from tiny ring X chromosomes in females with severe phenotypes. Proc Natl Acad Sci USA 90: 12025-29, 1993.
• Migeon BR, Kazi E, Haisley-Royster C, Hu J, Reeves R, Call L, Lawler A, Moore CS, Morrison H, Jeppesen P: Human X inactivation center induces random X chromosome inactivation in male transgenic mice. Genomics 59: 113-121, 1999.
• Migeon BR, Chowdhury AS, Dunston JA, McIntosh, I: Identification of TSIX, encoding an RNA antisense to human XIST, reveals differences from its murine counterpart: Implications for X inactivation. Am J Hum Genet 69: 951-960, 2001.
• Migeon BR, Lee CH, Chowdhury AS, Carpenter H. Species differences in TSIX/Tsix reveal the roles of these genes in X chromosome inactivation. Am J Hum Genet 71:286-293, 2002.
• Migeon, BR. Is Tsix repression of Xist specific to mouse? Nature Genetics 33:337, 2003.
• Bicocchi, MP, Migeon, BR, Pasino, M, Lanza T, Bottini F, Boeri E, Molinari AC, Corsolini F, Morerio C, Acquila M. Familial non-random inactivation linked to the X inactivation centre in heterozygotes manifesting hemophilia A. European J Hum Genet 13(5):635-40, 2005.
• Migeon, BR, Axelman, J, Jeppesen, P. Differential X reactivation in human placental cells:  Insights into reversal of X inactivation. Am J Hum Genet 77:355-364, 2005.
• Migeon, BR. "The Role of X Inactivation and Cellular Mosaicism in Women's Health and Sex-Specific Diseases," JAMA 2006; 295:1428-1433.
• Migeon BR. Females are Mosaics: X inactivation and sex differences in disease.  New York & London: Oxford University Press; 2007: 257pp.
• Migeon B, Pappas K, Stetten G, Trunca C, Jacobs P. X inactivation in triploidy and trisomy; the search for autosomal transfactors involved in choice of active X, 2007 submitted.

Contact Information:

Barbara R. Migeon, M.D.

Johns Hopkins University School of Medicine
Institute of Genetic Medicine
733 N Broadway, 459
Baltimore, MD  21205
Phone: (410) 955-3049
Fax: (410) 614-8600
E-Mail: bmigeon@jhmi.edu