Cutting, Garry, M.D.

Education and Training:

B.S., University of Connecticut, 1979
M.D., University of Connecticut, 1983  
Pedicatric Resident, Johns Hopkins University, SOM,  1986
Fellowship Clinical Genetics, Johns Hopkins University, SOM, 1989

Main Interests:

Molecular genetics of chronic sinopulmonary diseases

Research Interests:

• Determining CFTR genotype in phenotypes that overlap with cystic fibrosis (atypical CF, chronic sinusitis, male
  infertility and obstructive lung diseases)
• Identifying genetic variants that contribute to chronic lung disease by linkage and candidate gene approaches
• Determining the biological role of the CFTR protein by identifying mutations in patients with CF characterization
  of CFTR transcripts and protein from patients of various genotypes and analysis of chloride conduction properties
  of mutated CFTR expressed in various cell types
• Structure/function analysis of chloride channels expressed in epithelial tissues and retinal neurons
• Link: Cystic Fibrosis Twin and Sibling Study 

Clinical Activities:

• Board Certification: National Board of Medical Examiners Maryland Board of Medical Examiners American Board of Pediatrics American Board of Human Genetics (Clinical Genetics, Biochemical Genetics and Molecular Genetics)
• Clinical Interests: Familial Sinopulmonary Diseases
• Clinics:
  
  DNA Diagnostic Laboratory Johns Hopkins Hospital
  CMSC 10-106
  600 N. Wolfe St.
  Baltimore, MD 21287
  Phone: 410-955-0483 Fax: 410-955-0484 E-mail: bkarczes@jhmi.edu
    
  Medical Genetics Clinic Johns Hopkins Outpatient Center (JHOC)
  8th floor, Pediatric Specialty Clinics area
  601 North Caroline Street
  Baltimore, MD 21205
  Phone: 410-955-3071 Fax: 410-614-9246 

Educational Activities:

• Director, Postdoctoral Clinical Genetics Fellowship Programs
• Preceptor, Predoctoral Training Program in Human Genetics
• Courses taught: Introduction to Pathobiology, Analytical Methods in Clinical Medicine, Jackson Lab Course, Human Genetics Lecture Series, Advanced Topics in Human Genetics, Molecular Mechanisms, Cellular and Molecular Medicine, Molecules & Cells Course
• Links:
  
  Medical Genetics Clinical Residency Program and Genetic Subspecialty Postdoctoral Fellowships 
  
  Predoctoral Training Program in Human Genetics 
  

Recognition and Leadership Roles:

Human Genetics Committee, Faculty Advancement Committee 
 
Publications:

• Hamosh A, Trapnell BC, Zeitlin PL, Montrose-Rafizadeh C, Rosenstein BJ, Crystal RG, Cutting GR: Severe deficiency of CFTR mRNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis. J Clin Invest 88:1880-1885, 1991. Abstract
  
  
• Cutting GR, Lu L, O'Hara B, Kasch LM, Donovan D, Shimada S, Antonarakis SE, Guggino WB, Uhl GR, Kazazian H Jr: Cloning of the gamma-aminobutyric acid (GABA) rho1 cDNA: A GABA receptor subunit highly expressed in the retina. Proc Natl Acad Sci (USA) 88:2673-2677, 1991. Abstract
  
  
• Chu CS, Trapnell BC, Curristin S, Cutting GR, Crystal RG: Genetic basis for variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA. Nat Genet 3:151-156, 1993. Abstract
  
  
• Kiesewetter S, Macek MJr, Davis C, Curristin SM, Chu CS, Graham C, Shrimpton AE, Cashman SM, Tsui LC, Mickle J, Amos J, Highsmith WE, Shuber A, Witt DR, Crystal RG, Cutting GR: A Mutation in the CFTR Produces Different Phenotypes Depending on Chromosomal Background. Nat Genet 5:274-278, 1993. Abstract
  
  
• Wang T-L, Hackam A, Guggino WB, Cutting GR: A single histidine residue is essential for zinc inhibition of GABA rho1 receptors. J Neurosci 15:7684-7691 , 1995. Abstract
  
  
• Fulmer SB, Schwiebert EM, Morales MM, Guggino WB, Cutting GR: Two cystic fibrosis transmembrane conductance regulator mutations have different effects on both pulmonary phenotype and regulation of outwardly rectified chloride currents. Proc Natl Acad Sci USA 92:6832-6836, 1995. Abstract
  
  
• Schwiebert EM, Egan ME, Hwang T-H, Fulmer SB, Allen SS, Cutting GR, Guggino WB: CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 81(7):1063-1073, 1995. Abstract
   
  
• Mickle J, Macek M Jr, Fulmer-Smentek S, Egan M, Schwiebert E, Guggino W, Moss R, Cutting GR: Mutations in the cystic fibrosis transmembrane conductance regulator gene associated with elevated sweat chloride concentrations in the absence of cystic fibrosis. Hum Mol Genet 7(4):729-735 , 1998. Abstract
  
  
• Wang XJ, Moylan B, Leopold D, Kim J, Rubenstein RC, Togias A, Proud D, Zeitlin PL, Cutting GR: Mutation in the gene responsible for cystic fibrosis and predisposition to chronic nosinusitis in the general population. JAMA 284:1814-1819, 2000. Abstract
  
  
• Milewski M, Mickle J, Cheng J, Guggino W, Moyer B, Stanton B, Cutting GR: A PDZ-binding motif is essential but not sufficient to localize the C-terminus of CFTR to the apical membrane. J Cell Sci 114:719-726, 2001. Abstract

Contact Information:

Garry Cutting, MD

Johns Hopkins University School of Medicine
Institute of Genetic Medicine
733 N Broadway
Broadway Research Building, 559
Baltimore, MD  21287-3914

Phone: (410) 955-1773
Fax: (410) 614-0213
E-Mail: gcutting@jhmi.edu