Cutler, David, Ph.D.

David Cutler, Ph.D. Assistant Professor, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Contact | Education | Interests | Research | Activities | Leadership | Publications

Education and Training:

B.A.,            University of Michigan, Ann Arbor,   1993 
Ph.D.,          University of California, Davis,        1999
Postdoc.,     Case Western Reserve University, Department of Genetics, 2000
Postdoc.,     Johns Hopkins University School of Medicine,  2002
                 

• Haplotype mapping of the human genome

Recognition and Leadership Roles:

• Member, The American Society for Human Genetics

Selected Publications:

Zwick ME, Cutler DJ, and Chakravarti A. (2001) “Genetic Variation Analysis of Neuropsychiatric traits.” 289-302. in Methods in Genomic Neuroscience, editors Hemin Chen and Steven Molden.

Lin S, Cutler DJ, Zwick ME, and Chakravarti A. (2002) “Haplotype inference in random population samples.” American Journal of Human Genetics. 71:1129–1137.

Marth G, Schuler G, Yeh R, Davenport R, Agarwala R, Church D, Wheelan S, Baker J, Ward M, Kholodov M, Phan L, Czabarka E, Murvai J, Cutler DJ, Wooding S, Rogers A, Chakravarti A, Harpending H, Kwok PY, Sherry S (2003) “Sequence variations in the public human genome data reflect a bottlenecked population history.” Proceedings of the National Academy of Sciences. 100: 376–381.

Mitchell AA, Cutler DJ, Chakravarti A. (2003). “Undetected Genotyping Errors Cause Apparent Over Transmission of Common Alleles in the Transmission Disequilibrium Test.” American Journal of Human Genetics. 72:598–610.

Badano JL, Kim JC, Hoskins BE, Lewis RA, Ansley SJ, Cutler DJ, Castellan C, Beales PL, Leroux, MR, Katsanis N (2003). “Heterozygous mutations in BBS1, BBS2 and BBS6 have a potential epistatic effect on Bardet-Biedl patients with two mutations at a second BBS locus.” Human Molecular Genetics. 12 (14): 1651-1659.

Thomas JW, Touchman JW, Blakesley RW, Bouffard GG, Beckstrom-Sternberg SM, Margulies EH, Blanchette M, Siepel AC, Thomas PJ, McDowell JC, Maskeri B, Hansen NF, Schwartz MS, Weber RJ, Kent WJ, Karolchik D, Bruen TC, Bevan R, Cutler DJ, Schwartz S, Elnitski L, Idol JR, Prasad AB, Lee-Lin SQ, Maduro VVB, Summers TJ, Portnoy ME, Dietrich NL, Akhter N, Ayele K, Benjamin B, Cariaga K, Brinkley CP, Brooks SY, Granite S, Guan X, Gupta J, Haghighi P, Ho SL, Huang MC, Karlins E, Laric PL, Legaspi R, Lim MJ, Maduro QL, Masiello CA, Mastrian SD, McCloskey JC, Pearson R, Stantripop S, Tiongson EE, Tran JT, Tsurgeon C, Vogt JL, Walker MA, Wetherby KD, Wiggins LS, Young AC, Zhang LH, Osoegawa K, Zhu B, Zhao B, Shu CL, De Jong PJ, Lawrence CE, Smit AF, Chakravarti A, Haussler D, Green P, Miller W, Green ED (2003). “Comparative analyses of multi-species sequences from targeted genomic regions.”  Nature. 424 (6950): 788-793.

The International HapMap Consortium, (2003) “The International HapMap Project.” Nature. 426:789-796.

Mitchell AA, Zwick ME, Chakravarti A, and Cutler DJ, (2004) “Discrepancies in dbSNP Confirmation Rates and Allele Frequency Distributions From Varying Genotyping Error Rates and Patterns.” Bioinformatics. 20: 1022-1032.

Wong CW, Albert TJ, Vega VB, Norton JE, Cutler DJ, Richmond TA, Stanton LW, Liu ET, and Miller LD (2004) “Tracking the Evolution of the SARS Coronavirus Using High- throughput, High-density Resequencing Arrays.”  Genome Research.  14:398-405.

The International HapMap Consortium, (2004) “Integrating Ethics and Science in the International HapMap Project.”  Nature Reviews Genetics. 5: 467-475.

Lin S, Chakravarti A, and Cutler DJ, (2004) “Haplotype and Missing Data Inference in Nuclear Families.” Genome Research. 14: 1624-1632.

Lin S, Chakravarti A, and Cutler DJ, (2004) “Exhaustive Allelic Transmission Disequilibrium Tests as a new approach to genome-wide association studies.” Nature Genetics. 36:1181-1188.

Zwick ME, Mcafee F, Cutler DJ, Read TD, Ravel J, Bowman GR, Galloway DR, and Mateczun A (2005) “Microarray-based resequencing of multiple Bacillus anthracis isolates.” Genome Biology 6(1):R10.

Wigginton JE, Cutler DJ, and Abecasis GR (2005) “A note on exact tests of Hardy-Weinberg equilibrium.” American Journal of Human Genetics. 76(5):887-93.

Emison ES, McCallion AS, Kashuk CS, Bush RT, Grice E, Lin S, Portnoy ME, Cutler DJ, Green ED, and Chakravarti A. (2005) “A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk.” Nature. 434:857-63.

Mitchell AA, Chakravarti A, and Cutler DJ, (2005) “On the probability that a novel variant is a disease-causing mutation.” Genome Research. 15:960-6.

Maitra A, Arking DE, Shivapurkar N, Ikeda M, Stastny V, Kassauei K, Sui G, Cutler DJ, Liu Y, Brimble SN, Noaksson K, Hyllner J, Schulz TC, Zeng X, Freed WJ, Crook J, Abraham S, Colman A, Sartipy P, Matsui SI, Carpenter M, Gazdar AF, Rao M, and Chakravarti A, (2005) “Genomic alterations in cultured human embryonic stem cells.” Nature Genetics. 37:1099-1103.

The International HapMap Consortium, (2005) “A haplotype map of the human genome.” Nature. 437:1299-1320.

Marchini J, Cutler DJ, Patterson N, Stephens M, Eskin E, Halperin E, Lin S, Qin ZS, Munro HM, Abecasis GR, and Donnelly P, (2006) “A comparison of phasing algorithms for trios and unrelated individuals.” American Journal of Human Genetics. 78:437-450.

David Cutler, Ph.D.

McKusick-Nathans Institute of Genetic Medicine
Johns Hopkins University School of Medicine
Broadway Research Building, Room 475
733 N. Broadway St.
Baltimore, MD 21205
(410) 502-7534

E-mail: dcutler@jhmi.edu