Karin Blakemore, MD

Professor, Departments of Gynecology and Obstetrics and Oncology, School of Medicine
Associate Professor, Department of Population and Family Health Sciences, School of Hygiene and Public Health

BA, University of Pennsylvania, 1975
M.D., Medical College of Ohio at Toledo, 1978
Resident in Obstetrics and Gynecology, New York University Medical Center, 1982
Fellow in Human Genetics, Yale University School of Medicine, 1985
Fellow in Maternal-Fetal Medicine, Washington University School of Medicine, 1987

Main Interests:

Research interests relate to genetic abnormalities of the fetus and include cytogenetic mosaicism in the placenta and the relevance of cytogenetic abnormalities to clinical diagnosis and embryonic development, with Dr. Gail Stetten, as well as studies related to normal and abnormal fetal growth and development, and advances using antepartum diagnostic imaging modalities, intrapartum maternal and fetal physiology and processes, and red cell and platelet alloimmunization. Experience with in utero fetal treatment and first trimester prenatal diagnosis led to a new area of research, in utero bone marrow transplantation for genetic disorders of the fetus. Using an animal model, our primary aim is to determine the critical factors which allow or disallow engraftment in the early fetus Clinical and educational interests: prenatal diagnosis, normal and high risk pregnancy; alloimmunization, obstetrical sonography, maternal or fetal genetic disorders, and labor.
 
Research Interests:

• Prenatal diagnosis and genetic abnormalities of the fetus
• Intrapartum maternal and fetal physiology
• Fetal therapy
• In utero bone marrow transplantation
• Red cell alloimmunization and platelet alloimmunization 

 Clinical Activities:

• Board Certification: American Board of Medical Genetics; American Board of Obstetrics and Gynecology (ABOG); Maternal-Fetal Medicine, ABOG
  
• Clinical Interests: Fetal diagnosis and treatment; obstetrical sonography; high risk obstetrics; intrapartum maternal-fetal physiology; management of hematologic disorders in the fetus
  
• Clinics:

Obstetrical Practice @ Green Spring Johns Hopkins at Green Spring Station
10755 Falls Road
Suite 420
Lutherville, MD
Phone: 410-583-2749 Fax: 410-583-2756
  
Obstetrical Sonography Johns Hopkins Hospital
600 N. Wolfe Street
Blalock 2
Baltimore, MD 21287
Phone: 410-955-8976
  
Prenatal Diagnostic Center
Phone: 410-955-3091 

Educational Activities:

• Fellowship Director, Maternal-Fetal Medicine
• Year II Medical Student Curriculum in Reproductive Endocrinology, The Johns Hopkins University School of Medicine: “Prenatal Diagnosis.”
• Co-Course Director, OB/GYN Ultrasound Course (Tri-State), sponsored by Johns Hopkins University School of Medicine
• Preceptor, first year medical students, Introduction to Clinical Medicine and American Medical Women's Association
• Preceptor, Clinical Aspects of Public Health Problems in the Mother and Newborn, Population and Family Health Sciences, Johns Hopkins University School of Hygiene and Public Health 

 Recognition and Leadership Roles:

• Member, Board of Directors, The Society for Maternal-Fetal Medicine
• Member, Maternal-Fetal Medicine Network Units Advisory Board, National Institute of Child Health and Human Development
• Member, Working Group 3 - Discussion of Ethical, Legal and Social Issues, Prenatal Gene Transfer: Scientific, Medical and Ethical Issues, The Third Gene Therapy Policy Conference, National Institutes of Health
• Member, Committee on Ethics, The American College of Obstetricians and Gynecologists
• Editorial Board Member, Fetal Diagnosis and Therapy 
• Editorial Board Member, Journal of Maternal-Fetal and Neonatal Medicine

 Honors and Awards:

• 1999-2001: Best Doctors in Baltimore, Baltimore on Line: Top Doctors
• 2002:  The Acclaimed Educator Award, Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Presented by the Residency Graduating Class of 2002
• 2003:  National Institutes of Health Distinction “Changing the Face of Medicine: Celebrating America’s Women Physicians,” displayed at the National Library of Medicine at the National Institutes of Health Bethesda, Maryland: displayed in the digital portrait gallery on the National Institutes of Health website. 

Funded Awards:

• 9/1/03 – 12/31/05 
  NIH-NIAID - 1 RO1 AI555683-01
     “A Canine Model for In Utero Bone Marrow Transplantation”
     Award: $583,333 (PI: Karin J. Blakemore)

Publications:

• Blakemore KJ, Watson MS, Samuelson J, Breg WR and Mahoney MJ: A method of processing first trimester chorionic villous biopsies for cytogenetic analysis. Am J Hum Genet ;36:1386-1393, 1984. Abstract
  
• Reddy KS, Petersen MB, Antonarakis SE, and Blakemore KJ: The vanishing twin: an explanation for discordance between chorionic villus karyotype and fetal phenotype. Prenat Diag Sep;11(9):679-84, 1991. Abstract
  
• Rosenberg C, Blakemore KJ, Kearns WG, Giraldez RA, Escallon CA, Pearson PL, and Stetten G: Analysis of reciprocal translocations by chromosome painting: applications and limitations of the technique. Am J Hum Genet Apr;50(4):700-5 , 1992. Abstract
  
• Blakemore KJ, Filkins K, Luthy D, Priest J, Platt L, Medearis A, Carlson D, Korotkin J, Verp M, Padilla L, Warsof S, Scommegna A, Weston P: Cook obstetrics and gynecology catheter multicenter chorionic villus sampling trial: comparison of birth defects with expected rates. Am J Obstet Gynecol Oct;169(4):1022-6 , 1993. Abstract
  
• Khouzami AN, Kickler TS, Bray PF, Callan NA, Sciscione AC, Shumway JB, Blakemore KJ: Molecular genotyping of fetal platelet antigens with uncultured amniocytes. Am J Obstet Gynecol Oct;173(4):1202-6, 1995. Abstract
  
• Hutchins GM, Meuli M, Meuli-Simmen C, Jordan MA, Heffez DS, Blakemore KJ: Acquired spinal cord injury in human fetuses with myelomeningocele. Pediatr Path & Lab Med Sep-Oct;16(5):701-12, 1996. Abstract
  
• Pressman EK, Blakemore KJ: A prospective randomized trial of two solutions for intrapartum amnioinfusion: effects on fetal electrolytes, osmolality, and acid-base status. Am J Obstet Gynecol Oct;175(4 Pt 1):945-9, 1996. Abstract
  
• Bambach BJ, Moser HW, Blakemore KJ, Corson VL, Griffin CA, Noga SJ, Perlman EJ, Zuckerman R, Wenger DA, Jones RJ: Engraftment following in utero bone marrow transplantation for globoid cell leukodystrophy. Bone Marrow Transplant Feb;19(4):399-402, 1997. Abstract
  
• Blakemore KJ, Moser HW, Corson VL, Griffin CA, Noga SJ, Zuckerman R, Wenger DA, Evans MI, Jones RJ: An update on in utero bone marrow transplantation for Krabbe disease. J Molec Neurosci 13:238-239, 1999.
  
• Driggers RW, Isbister S, McShane C, Stone K, Blakemore K: Early second trimester prenatal diagnosis of Neu-Laxova syndrome. Pren Diag 22:118-20, 2002.
  
• Leung W, Blakemore K, Jones RJ, Moser HW, Mukherjee G, Griffin CA, Rosenblum-Vos LS, Civin CI.  Brief report: A human/murine chimera model for in utero human hematopoietic stem cell transplantation.  Biol Blood & Marrow Transplantation 1999;5:1-7.
  
• Driggers RW, Bernstein H, Lantz M, Stetten G, Escallon CS, Perlman E, Blakemore K.  Non-mosaic trisomy 20 presenting as a thoraco-abdominal mass.  Prenatal Diagn 2001;21:387-9.
  
• Deering S, Bienstock J, Blakemore K, Hueppchen N.  Maternal serum alpha-fetoprotein levels in pregnancies with fetal cleft lip and palate.  Am J Hum Genet 2001;69:660 (Abstract #2813).
  
• Driggers RW, Isbister S, McShane C, Stone K, Blakemore K.  Early second trimester prenatal diagnosis of Neu-Laxova syndrome.  Pren Diag 2002;22:118-20.
  
• Nguyen C, Duhl AJ, Escallon CS, Blakemore KJ.  Multiple anomalies in a fetus exposed to low-dose methotrexate in the first trimester.  Obstet Gynecol 2002;99:599-602.
  
• Albayram F, Stone K, Nagey D, Schwarz K, Blakemore B.  Alagille syndrome: prenatal diagnosis and pregnancy outcome.  Fetal Diag & Ther 2002;17:182-184.
  
• Volmar KE, Nguyen TC, Holcroft CJ, Blakemore KJ, Hutchins GM. Phimosis as a cause of the prune belly syndrome: comparison to a more common pattern of proximal penile urethra obstruction. Virchows Archiv - Int’l J Path 2003;442:169-72.
  
• Blakemore K, Hattenburg C, Stetten G, Berg K, South S, Murphy K, Jones R.  In utero hematopoietic stem cell transplantation using haploidentical donor adult bone marrow in a canine model.  Am J Obstet Gynecol 2004;190:960-73.
  
• Kwiterovich PO, Virgil DG, Garrett E, Otvos J, Driggers R, Blakemore K, Cockrill SL.  Lipoprotein heterogeneity at birth: influence of gestational age and race on lipoprotein subclasses. Ethnicity and Disease 2004;14:351-359.
  
• Stetten G, Escallon C, South S, McMichael J, Saul D, Blakemore K.  Reevaluating confined placental mosaicism.  Am J Med Genet 2004;131A:232-239.
  
• South ST, Corson VL, McMichael JL, Blakemore KJ, Stetten G.  Prenatal detection of an interstitial deletion in 4p15 in a fetus with an increased nuchal skin fold measurement.  Fetal Diagn Ther 2005;20:58-63.

Contact Information:

Karin Blakemore, MD

The Johns Hopkins Hospital
Dept. of Gynecology & Obstetrics
Phipps Building, Room 228
Baltimore, MD 21287-1228
Phone: (410) 955-6207
Fax: (410) 614-8305
E-Mail: dwheele@jhmi.edu