Assistant Professor, McKusick-Nathans Institute of Genetic Medicine and |  |
| Contact | Education | Interests | Research | Activities | Leadership | Publications | |
B.S. University of Maryland, College Park, 1995
Ph.D. Johns Hopkins University School of Medicine, 2001
Classically, the identification of genetic determinants of disease has been achieved through the use of family-based linkage studies. Although this approach has proven extremely successful for monogenic disease, it has fallen far short in identifying genetic determinants of complex disease. Thus, association studies, which rely upon linkage disequilibrium between the causal variant and a nearby marker, have been proposed. Association studies have focused on candidate gene studies, usually genotyping a few single nucleotide polymorphisms (SNPs) in a few genes. Not surprisingly, these studies have had limited success, owing to a combination of insufficient markers tested to comprehensively study a gene, and a limited ability to select candidate genes, as less than 1/3 of genes have a known function. Given these limitations, my research focuses on improving candidate gene selection and screening, as well as developing novel technologies that allow for unbiased genome-wide association studies.
- Genetics of complex disease
- Cardiovascular disease and sudden cardiac death
- Development and implementation of novel genotyping technologies
Recognition and Leadership Roles:
- Member, The American Society for Human Genetics
- Scientific Advisory Board Member, Association for Eradication of Heart Attack (AEHA)
Arking, D. E., M. Macek Jr., A. Krebsova, M. Macek Sr., A. Arking, I. S. Mian, L. Fried, A. Hamosh, S. Dey, I. McIntosh, and H. C. Dietz. 2002. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci USA. 99(2):856-861.
Neptune, E. R., P. A. Frischmeyer, D. E. Arking, T. E. Bunton, L. Myers, and H. C. Dietz. 2003. Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nature Genetics. 33(3):407-11.
Arking, D. E., D. M. Becker, L. R. Yanek, D. Fallin, D. P. Judge, T. F. Moy, L. C. Becker, and H. C. Dietz. 2003. KLOTHO allele status and the risk for early-onset occult coronary artery disease. Am. J. Hum. Genet. 72:1154-1161.
Arking, D. E., S. S. Chugh, A. Chakravarti, and P. M. Spooner. 2004. Genomics in Sudden Cardiac Death. Circulation Research. 94:712-723.
Arking, D. E., G. Atzmon, A. Arking, N. Barzilai, and H. C. Dietz. 2005. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circulation Research. 96(4):412-418.
Maitra, A.,* D. E. Arking,* N. Shivapurkar, M. Ikeda, V. Stastny, K. Kassauei, G. Sui, D. J. Cutler, Y. Liu, S. N. Brimble, K. Noaksson, J. Hyllner, T. C. Schulz, X. Zeng, W. J. Freed, A. Colman, P. Sartipy, M. Carpenter, A. F. Gazdar, M. Rao, and A. Chakravarti. 2005. Genomic Alterations in Cultured Human Embryonic Stem Cells. Nature Genetics. 37(10):1099-1103. *These authors contributed equally to the work.
Arking, Dan E., M. Daniele Fallin, Tao Li, Brock A. Beamer, Qian Li Xue, Linda P. Fried, Aravinda Chakravarti and Jeremy Walston. 2006. Variation in the Ciliary Neurotrophic Factor Gene and Muscle Strength in Older Caucasian Women. J Am Geriatr Soc. May;54(5):823-6.
Dan E. Arking*, Arne Pfeufer*, Wendy Post, W.H. Linda Kao, Christopher Newton-Cheh, Morna Ikeda, Kristen West, Carl Kashuk, Mahmut Akyol, Siegfried Perz, Shapour, Jalilzadeh, Thomas Illig, Christain Gieger, Chao-yu Guo, Martin G. Larson, H. Erich Wichmann, Eduardo Marbán, Christopher J. O’Donnell, Joel N. Hirschhorn, Stefan Kaab, Peter M. Spooner, Thomas Meitinger, and Aravinda Chakravarti. 2006. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nature Genetics. Jun;38(6):644-651. *These authors contributed equally to the work.
Eric S. Calhoun, Tomas Hucl, Eike Gallmeier, Kristen M. West, Dan E. Arking, Anirban Maitra, Christine A. Iacobuzio-Donahue, Aravinda Chakravarti, Ralph H. Hruban, Scott E. Kern. 2006. Identifying Allelic Loss and Homozygous Deletions in Pancreatic Cancer Without Matched Normals Using High-density SNP Arrays. Cancer Res. 2006 Aug 15;66(16):7920-7928.
Marina Bibikova, Eugene Chudin, Bonnie Wu, Eliza Wickham Garcia, Todd Plaia, Jonathan Auerbach, Anirban Maitra, Rudolfo Gonzalez, Dan E Arking, Jeremy Crook, Bruce Davidson, Thomas C Schulz, Alan Robins, Aparna Khanna, Peter Sartipy, Johan Hyllner, Aravinda Chakravarti, Mahendra Rao, David L Barker, Jeanne F Loring and Jian-Bing Fan. A Common Epigenetic Signature Distinguishes Human Embryonic Stem Cells from Differentiated Cell Populations. Genome Res. 2006 Aug 9; [Epub ahead of print]
Wendy Post, Haiqing Shen, Coleen Damcott, Dan E. Arking, W.H. Linda Kao, Paul A. Sack, Kathleen A. Ryan, Aravinda Chakravarti, Braxton D. Mitchell, Alan R. Shuldiner. Associations between Genetic Variants in the NOS1AP (CAPON) Gene and Cardiac Repolarization in the Old Order Amish. Hum Hered. 2007;64(4):214-9.
Tsung-Cheng Chang, Erik A Wentzel, Oliver A Kent, Kalyani Ramachandran, Michael Mullendore, Kwang Hyuck Lee, Dan E Arking, Michael A Beer, Anirban Maitra, and Joshua T. Mendell. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007 Jun 8;26(5):745-52.
Tsung-Cheng Chang, Duonan Yu, Yun-Sil Lee, Dan E Arking, Kristin M West, Chi V Dang, Andrei Thomas-Tikhonenko, and Joshua T Mendell. Widespread microRNA repression by c-Myc promotes tumorigenesis. (in press, Nature Genetics)
Dan E. Arking, David J. Cutler, Camille W. Brune, Tanya M. Teslovich, Kristen West, Morna Ikeda, Alexis Rea, Moltu Guy, Shin Lin, Edwin H. Cook Jr. & Aravinda Chakravarti. A common genetic variant in the neurexin-superfamily member CNTNAP2 increases familial risk of autism. (in press, AJHG)
Lauren A. Weiss, Yiping Shen, Joshua M. Korn, Dan E. Arking, David T. Miller, Manuel A. R. Ferreira, Todd Green, Orah S. Platt, Douglas M. Ruderfer, Rudolph E. Tanzi, Christopher A. Walsh, Investigators of the Autism Consortium, Aravinda Chakravarti, Susan L. Santangelo, James F. Gusella, Pamela Sklar, Bai-Lin Wu, Mark J. Daly. A recurrent genetic cause of autism: a microdeletion at 16p11.2. (in press, NEJM).
Dan E. Arking, Ph.D.
McKusick-Nathans Institute of Genetic Medicine
Johns Hopkins University School of Medicine
Broadway Research Building, Room 580
733 N. Broadway St.
Baltimore, MD 21205
(410) 502-7531
E-mail: arking@jhmi.edu
