The
GCRC supports a Biostatistics and Computerized
Data Management and Analysis System (CDMAS) core directed by
Joe Coresh M.D., Ph.D., M.H.S. The core includes a number of statisticians
who divide the duties of protocol review and consultation as follows:
Adult GCRC
committee: Brad Astor, Ph.D., M.P.H.,
Joe Coresh, M.D, Ph.D., M.H.S.,
Kathryn "Kit" Carson, Sc.M,
and Richard E. Thompson, Ph.D.
Pediatric
GCRC committee: Kathryn "Kit" Carson
Sc.M. and Steve Goodman,
M.D., Ph.D.
Neurobehavioral
Research unit: Richard E. Thompson, Ph.D.
We recommend that you contact statisticians in the order listed for each committee. The
Biostatistics core supports clinical investigators through Protocol
Review, Consultation,
Collaboration,
Teaching,
Methodologic
Innovation, and Bridge
Building Meeting with investigators can both improve the study design
and speed protocol review since design and analysis issues are addressed up-front.
It is strongly suggested that a biostatistician review the protocol prior to submission.
As a result of this review, the statistician can provide investigators with a
written critique summarizing the biostatistical & design issues of the study,
which will be shared with the reviewing statistician.Recommended
revisions should be made before the protocol is submitted to the GCRC Protocol
Review Committee. However, this review process does not guarantee that there will
be no biostatistical or design issues raised at the review committee meeting.
 Brad
Astor (410-502-2779, ) obtained his M.P.H. and
Ph.D. in Epidemiology at the Johns Hopkins School of Public Health.
His primary areas of research at the Welch Center for Prevention,
Epidemiology and Clinical Research are kidney and cardiovascular
disease and imaging technology to detect subclinical cardiovascular
disease. He has published on a variety of topics in these areas,
including the cardiovascular effects of anemia associated with chronic
kidney disease. Dr. Astor teaches in the Principles of Epidemiology
II course in the Bloomberg School of Public Health. His previous
experience includes over 12 years with the U.S. Food and Drug Administration,
where he reviewed applications for investigational medical devices
to be used in interventional cardiology. He joined the GCRC in 2001,
and has since been involved in a wide variety of studies on both
the Adult GCRC and the Neurobehavioral Research Unit.
Kathryn Carson (410-955-4380,
) obtained
her Sc.M. in Biostatistics at the Johns Hopkins School of Public
Health. She is a Senior Biostatistician in the Department of Epidemiology,
Bloomberg School of Public Health. In addition to the GCRC, Mrs.
Carson works with the New Approaches to Brain Tumor Therapy (NABTT)
CNS consortium at the Sidney Kimmel Comprehensive Cancer Center
at Johns Hopkins and the Atherosclerosis Risk in Communities (ARIC)
Study. She has taught data management in the GCRC-sponsored Methods
in Clinical Research course and is an ad hoc statistical reviewer
for Annals of Internal Medicine. Prior to coming to the GCRC, Ms.
Carson worked on the Lipid Research Clinics Coronary Prevention
Project as well as in the Alzheimer’s Disease Research Center.
Since coming to the GCRC in 1998, Ms. Carson has been a member of
the Adult and Pediatric Protocol Review Subcommittees, as well as
having primary responsibility for expedited reviews of multi-center
NIH approved protocols (ACTG). In addition, she has collaborated
with many GCRC Investigators in the analysis of data and the writing
of manuscripts and grants.
Joe Coresh (410-955-0409,
) is trained in medicine
(MD, Johns Hopkins), epidemiology (PhD, Johns Hopkins), and biostatistics
(MHS, Johns Hopkins), as well as his BA in mathematics (Princeton
University). He leads the Biostatistics & Bioinformatics core
of the GCRC as well as maintains his own independent research into
cardiovascular and kidney disease epidemiology. As an active investigator
himself, he is acutely aware of the needs of GCRC researchers. He
has published on the epidemiology of cardiovascular and renal disease
as well as worked on improved methodology for non-parametric adjustment
of survival curves, and the application of statistical methods to
genetic epidemiology. Dr. Coresh's primary appointment is in Epidemiology
with joint appointments in Medicine and Biostatistics as well as membership
in the Welch Center for Prevention, Epidemiology and Clinical Research.
Indicative of his teaching skill and involvement, Dr. Coresh has won
Advising, Mentoring & Teaching Recognition Awards at the Johns
Hopkins School of Public Health in 1998 & 2000. He has taught
statistical methods in the GCRC-sponsored Methods in Clinical Research
course as well as in the Graduate Training Program in Clinical Investigation
evening course for clinical researchers. Dr. Coresh directs the Clinical
Epidemiology course for first year medical students and his advice
has helped in the translation of a number of GCRC protocols into NIH
funded grants.
Steve Goodman (410-955-4596,
) is an Associate
Professor of Oncology, Pediatrics, Epidemiology and Biostatistics
at the Johns Hopkins Schools of Medicine and Public Health. He received
his BA from Harvard, MD from New York University, completed a pediatric
residency at Washington University, and received an MHS in Biostatistics
and PhD in Epidemiology from Johns Hopkins. He is also a member
of the Biostatistics division in the Department of Oncology, whose
programs are active investigations on the GCRC. Since becoming the
Adult Inpatient and Pediatric GCRC Biostatistician in 1992, he has
consulted with many GCRC investigators, and now focuses on the pediatric
side. He has taught clinical research methods to a wide range of
audiences at Johns Hopkins, including co-directing (with Drs. Klag,
Guallar and Coresh) a 2-week summer course on Clinical Research
Methods, and leading courses in Meta-analysis, Inference in Epidemiologic
Studies and Clinical Trials, and the Doctoral Seminar in the Department
of Epidemiology. He also has interests in the ethics of clinical
research, and lectures in numerous ethics courses aimed at faculty,
fellows and public health students. He is co-director of the Hopkins
Evidence-Based Practice Center, has been statistical editor of the
Annals of Internal Medicine since 1987, and serves on a variety
of national panels, including the Institute of Medicine's Committee
on Immunization Safety and the Surgeon General's committees to write
the 2001 and 2002 reports. He is a member of the Medical Advisory
Panel for the National Blue Cross/Blue Shield technology assessment
program, is a member of the national Medicare Coverage Advisory
Committee and is on the external Advisory Board for MD Anderson
Cancer Center. In 2000, he was a recipient of the Harvard Department
of Biostatistics Myrto Lefkopoulou Distinguished Lectureship. At
Johns Hopkins, he is on the faculties of the Center for Clinical
Trials, the Hopkins Bioethics Institute, the Graduate Training Program
in Clinical Investigation and the Center for the History and Philosophy
of Science. He has collaborated on a wide range of studies in cancer
research, and writes extensively on inferential, methodologic and
ethical issues in clinical research and epidemiology.
Richard E. Thompson (410-614-4370, email) is an Assistant Scientist in Biostatistics at the
Johns Hopkins Bloomberg School of Public Health. He received his B.A. in physics from Manchester College, North Manchester, IN, his M.S.
in physics from the University of Notre Dame, and his Ph.D. in biometry from Medical University of South Carolina. His primary field of
research is in the area of environmental statistics. Currently, Dr. Thompson serves as the Associate Director of the Johns Hopkins Biostatistics
Center. In this capacity, he has collaborated with several clinical and medical investigators through the Johns Hopkins Medical Institutes.
He has co-authored several papers in a variety of medical fields including cardiology, radiology, neurology, gastroenterology, and medical
genetics. In addition, he teaches a STATA-based class entitled “Regression Analysis in Public Health Research Laboratory” for the Graduate
Summer Institute in Biostatistics and Epidemiology. Dr. Thompson joined the GCRC in the fall of 2004, and currently reviews grant proposals
for the Adult and Neurobehavioral Research Unit Protocol Review Subcommittees.
|
