To use the GCRC facilites and funding, you must submit a protocol application. All applications must be approved by both the Institutional Review Board (IRB) and the GCRC Advisory Committee (GAC) after internal scientific review by the Protocol Review SubCommittee. To obtain IRB approval, submit application through the IRB. To obtain GCRC approval, submit an application to the GCRC. Once your application goes through the review process and is approved, you can start using the many resources available to you from the GCRC.