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Total Pancreatectomy and Islet Autotransplantation Program


The Total Pancreatectomy and Islet Autotransplantation Program offers a procedure for patients with acute recurrent and chronic pancreatitis who have chronic severe abdominal pain and who do not respond to conventional treatment.

In the first part of the double procedure, the pancreas is surgically removed (called a total pancreatectomy). In the second part of the procedure, auto islets (insulin-producing cells found in the pancreas) are removed from the pancreas and transplanted to the liver.

The pancreatectomy relieves pain while the auto islet transplantation reduces the need for insulin, which would otherwise be necessary for people without a pancreas.

Benefits of Pancreatectomy and Islet Autotransplantation

Approximately 80 percent of patients experience significant reduction, if not resolution, of pain after the pancreas is removed. Over time, some patients may become diabetic and need insulin.

Having this surgery done at Johns Hopkins provides patients with the reassurance that a surgeon who specializes in pancreatic surgery and islet autotransplantation will be doing the procedure, assisted by a team of other doctors and nurses who are also specialists.

Patients who are candidates for this procedure will be treated by a multidisciplinary team that will look at every aspect of the patient’s health and lifestyle to make sure that procedure will offer the patient the most benefit and the least risk.

Program Faculty and Staff

Vikesh K. Singh, M.D., M.Sc., Medical Director  
Ellen Stein. M.D. 

Martin A. Makary, M.D., M.P.H., Surgical Director
Kenzo Hirose, M.D.
Christi Walsh, CRNP, Islet Autotransplant Coordinator 

Islet Autotransplantation Team 
Niraj Desai, M.D.
Zhaoli Sun, M.D., PhD
Daniel Warren, PhD

Rita Kalyani, M.D.
Erica Hall, CRNP

Atif Zaheer, M.D. (Diagnostic)
Clifford Weiss, M.D. (Interventional)

Asad Latif, M.D.

Chronic Pain
Maneesh Sharma, M.D. 


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