Protocol Number: NA_00038329
Physician: Steven R. Brant, M.D.
The causes of inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are unknown, and diagnosing them is often difficult. This research is being done to:
- Find the genes that may increase the risk of IBD
- Identify specific protein substances and micro-organisms in the gastrointestinal tract (such as bacteria) that are related to IBD
- Look at cell factors that may predict response to treatment for IBD
- Characterize intestinal cells in CD and UC patients
- Investigate mechanisms of small bowel regeneration
In patients with IBD, cells of the gastrointestinal tract do not seem to respond to certain substances in a normal way. Scientists have discovered that the immune system, made up of cells and chemicals that defend the body from infections, is working in a way that damages the gastrointestinal walls. Intestinal cell regeneration may lead to the identification of new ways to control cell growth and differentiation to repair intestinal mucosa not only in CD and UC diseases but also in other gastrointestinal disorders such as celiac disease and ischemic bowel or following irradiation.
Joining the Study
Patients who are going to have a medical or surgical procedure performed related to a diagnosis of CD or UC or for other medical reasons may be asked to join the study.
Researchers will study the cells in the tissue removed from the gastrointestinal tract to find out why some cells do not act in the normal way in people with IBD as compared to people without IBD. The more we understand about how differently these cells are working, the better doctors and scientists will be able to someday help people with IBD.
If you join the study, you will be asked to:
- Give information about your health, including related IBD diagnosis and treatment and family history of IBD.
- Give a blood sample, about 3 tablespoons (less for small children).
- Give us permission to collect a tissue sample during your procedure.
Who is Eligible?
People who are scheduled to have:
- An upper or lower gastrointestinal endoscopy at Johns Hopkins
- A bowel resection at Johns Hopkins
There is no cost to participate. You will not be paid if you join this study.
For More Information
The Johns Hopkins Crohn's and Ulcerative Colitis Genetics Study
1503 E Jefferson St, Ste B137
Baltimore, MD 21231
Phone: 410-614-1982, 888-279-4194 or 410-502-5846