Skip Navigation
 
 
 
 
 
Print This Page
Share this page: More
 

Conditions We Treat: APC I1307K and Colorectal Cancer

In 1997, a Johns Hopkins research team found an inherited genetic mutation called APC I1307K. Adenomatous polyposis coli, or APC, is a gene that suppresses tumor growth. If the APC gene is defective, it makes the gene unstable and more susceptible to additional changes that may lead to colorectal cancer.

The APC I1307K mutation is primarily found in people of Ashkenazi Jewish heritage (Jews of Eastern European or Russian ancestry). Researchers believe that six percent of Ashkenazi Jews carry this gene mutation, making them at a significantly higher risk for developing colorectal cancer.

APC I1307K: What You Need to Know

Woman on Laptop
  • If you are of Ashkenazi Jewish descent, talk to your doctor about getting tested for this genetic mutation.
  • The Johns Hopkins Colon Cancer Risk Assessment Clinic evaluates patients who are at increased risk for developing colorectal cancer.
  • If you test positive for the gene, your doctor will want to perform regular colonoscopies to detect signs of early cancer.
  • If your doctor finds cancer during the diagnosis phase, he or she may recommend surgery as a course of treatment.

Patient Resources

Request an Appointment

 

Why choose Johns Hopkins Division of Gastroenterology and Hepatology for APC I307K?

GI physicians gathered around surgery table

Our Physicians

Doctors at Johns Hopkins lead the way in researching the APC I1307K mutation and providing information to patients who have it.

Meet our physicians:
""

Our Services

The Colon Cancer Risk Assessment Clinic is specially designed to evaluate patients who have a family history of colon cancer.

Learn more about the clinic’s services.

 

 

Employee Intranet

 

Traveling for care?

blue suitcase

Whether crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.

Maryland 410-933-7495
U.S. 1-410-464-6713 (toll free)
International +1-410-614-6424

 

 

 
 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.

Privacy Policy and Disclaimer