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In 1997, a Johns Hopkins research team found an inherited genetic mutation called APC I1307K. Adenomatous polyposis coli, or APC, is a gene that suppresses tumor growth. If the APC gene is defective, it makes the gene unstable and more susceptible to additional changes that may lead to colorectal cancer.
The APC I1307K mutation is primarily found in people of Ashkenazi Jewish heritage (Jews of Eastern European or Russian ancestry). Researchers believe that six percent of Ashkenazi Jews carry this gene mutation, making them at a significantly higher risk for developing colorectal cancer.
Read a more in-depth article about APC I1307K, written by Johns Hopkins gastroenterologists, which details the anatomical description of the causes of APC I1307K.
Read our FAQs about APC I1307K.
Doctors at Johns Hopkins lead the way in researching the APC I1307K mutation and providing information to patients who have it.Meet our physicians:
The Colon Cancer Risk Assessment Clinic is specially designed to evaluate patients who have a family history of colon cancer.Learn more about the clinic’s services.