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Roberto Salvatori, M.D.


Research interests

Dr. Salvatori’s primary research interest centers around identifying the genetic causes of isolated growth hormone deficiency (GHD) and the consequences of untreated GHD. He has been studying GHD patients who have never received GH to determine whether they have different prevalence of cardiovascular diseases and whether the GHD affects their bone density, quality of life, reproductive function, and longevity. In addition, he has created a mouse model of isolated GHD, by removing a gene necessary for the production of GH (GHRH).

Recent publications 

 •Longevity in Untreated Congenital Growth Hormone Deficiency Due to a Homozygous Mutation in the GHRH Receptor

•Lack of Evidence of Premature Atherosclerosis in Untreated Severe Isolated Growth Hormone Deficiency Due to a GHRH Receptor Mutation.

•Adipokines profile and urinary albumin excretion in isolated GH deficiency

•.Climacteric in Untreated Isolated Growth Hormone Deficiency

•Effectiveness of self- or partner-administration of an extended-release aqueous gel formulation of lanreotide in lanreotide-naïve patients with acromegaly

•Consequences of Lifetime Isolated Growth Hormone (GH) Deficiency and Effects of Short-Term  GH Treatment on Bone in Adults  with a Mutation in the GHRH-receptor Gene

•Quality of Life in Congenital, Untreated, Lifetime Isolated Growth Hormone Deficiency

•Gene Mutation Analysis of the Muscarinic Cholinergic Receptor Genes in Isolated Growth Hormone Deficiency Type IB

•Partial rescue of growth failure in growth hormone (GH)-deficient mice by a single injection of a double-stranded adeno-associated viral vector expressing the GH gene driven by a muscle-specific regulatory cassette

• Recurrence of hyperprolactinemia following withdrawal of long-term cabergoline

•Congenital growth hormone (GH) deficiency and atherosclerosis: Effects of GH replacement in GH-naive adults

•Partial reversibility of GH deficiency in the GHRH knock out mouse by postnatal treatment with a GHRH-analogue

•A mouse with targeted ablation of the GHRH gene: a new model of isolated GH deficiency

•Decreased expression of the growth hormone-releasing hormone receptor gene due to a mutation in a Pit-1 binding site

•Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB

•Familial dwarfism due to a novel mutation in the growth hormone-releasing hormone receptor



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