Research interests
Dr. Salvatori’s primary research interest centers around identifying the genetic causes of isolated growth hormone deficiency (GHD) and the consequences of untreated GHD. He has been studying GHD patients who have never received GH to determine whether they have a higher prevalence of cardiovascular diseases. In addition, he has created a mouse model of isolated GHD, by removing a gene necessary for the production of GH (GHRH).
Recent publications- Partial reversibility of GH deficiency in the GHRH knock out mouse by postnatal treatment with a GHRH-analogue
- A mouse with targeted ablation of the GHRH gene: a new model of isolated GH deficiency
- Variability in anterior pituitary size within members of a family with GH deficiency due to a new splice mutation in the GHRH receptor gene
- Serum GH response to pharmacological stimuli and physical exercise in two siblings with two new inactivating mutations in the GH-releasing hormone receptor gene
- Detection of a recurring mutation in the human GH-releasing hormone receptor gene
- Decreased expression of the growth hormone-releasing hormone receptor gene due to a mutation in a Pit-1 binding site
- Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB
- Familial dwarfism due to a novel mutation in the growth hormone-releasing hormone receptor
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