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Paul W. Ladenson, M.D.

Research

Research interests

Dr. Ladenson’s research interests include applications of thyroid hormone analogues for treatment of cardiovascular disease, novel approaches to thyroid cancer diagnosis and management, and health economic analyses related to thyroid patient care.  Currently, Dr. Ladenson is investigating effects of the thyroid hormone analogue eprotirome on dyslipidemia, and applications of BRAF mutation analysis and recombinant thyrotropin in thyroid cancer management.

Recent publications 

•Schroeder PR, Haugen BR, Pacini F, Reiners C, Schlumberger M, Sherman SI, Cooper DS, Schuff KG, Braverman LE, Skarulis MC, Davies TF, Mazzaferri EL, Daniels GH, Ross DS, Luster M, Samuels MH, Weintraub BD, Ridgway EC, Ladenson PW. A Comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with rhTSH compared to thyroid hormone withdrawal. J Clin Endocrinol Metab 2006;91:878-84

•Cappola AR, Fried LP, Arnold AM, Danese MD, Kuller LH, Burke GL, Tracy RP, Ladenson PW. Thyroid status, cardiovascular risk, and mortality in older adults: the cardiovascular health study. JAMA 2006;295:1033-1041

•Golden SH, Robinson KA, Saldanha I, Anton B, Ladenson PW. Prevalence and Incidence of Endocrine and Metabolic Disorders in the United States:  A Comprehensive Review. J Clin Endocrinol Metab 2009;94:1853-78

•Goldman S, McCarren M, Morkin E, Ladenson PW, Edson R, Warren S, Ohm J, Thai H, Churby L, Barnhill J, O’Brien T, Anand I, Warner A, Dunlap M, Hattler B, Erikson J, Shih M-C, Lavori P.  DITPA, a Thyroid Hormone Analog to Treat Heart Failure: Phase II Trial VA Cooperative Study. Circulation 2009;119;3093-3100

•Elisei R, Schlumberger M, Driedger A, Reiners C,  Kloos RT, Sherman SI, Haugen B, Corone C, Molinaro E, Grasso L, Leboulleux S, Rachinsky I, Luster M, Lassmann M, Busaidy L, Wahl RL, Pacini F, Cho S, Magner J, Pinchera A, Ladenson PW.  Follow-up of differentiated thyroid cancer patients who underwent radioiodine ablation of postsurgical thyroid remnants after either recombinant human thyrotropin or thyroid hormone withdrawal. J Clin Endocrinol Metab 2009;94:4171-9

•Ladenson PW, McCarren M, Morkin E, Edson RG, Shih M-C, Warren SR, Barnhill JG, Churby L, Thai H, O’Brien T, Anand I, Warner A, Hattler B, Dunlap M, Erikson J, Goldman S. Effects of the Thyromimetic Agent Diiodothyropropionic Acid (DITPA) on Body Weight, BMI, And Serum Lipoproteins: A Pilot Prospective, Randomized, Controlled Study. J Clin Endocrinol Metab 2010;95:1349-1354

•Ladenson PW, Kristensen JD, Ridgway EC, Olsson AG, Carlsson B, Klein I, Baxter JD, Angelin B. Treatment of dyslipidemia with the thyroid hormone analog eprotirome in statin-treated patients. New Engl J Med 2010;362:906-916

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