Dr. Kalyani’s research focuses on the decreased physical functioning observed in patients with diabetes as they age. Her previous research has demonstrated that adults with diabetes are more likely to have difficulties performing a wide range of routine physical tasks such as climbing the stairs, lifting objects overhead, doing house chores, and participating in leisure activities. Through several ongoing epidemiological cohorts, she has been investigating the association of high blood glucose and high insulin levels with accelerated muscle loss, and possible contributions to the physical disability observed in diabetes. Dr. Kalyani is currently involved in clinical studies that aim to understand the underlying mechanisms for these associations and may ultimately facilitate development of novel preventive strategies to prevent muscle loss and disability in persons with diabetes.
Dr. Kalyani also serves as the managing editor for the Johns Hopkins Diabetes Guide, available at www.hopkins-diabetesguide.org .
- 1. Kalyani RR, Stein B, Valiyil R, Manno R, Maynard JW, Crews DC. Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. J Am Geriatr Soc. 2010 Jul;58(7):1299-310
- 2. Kalyani RR, Saudek CD, Brancati FL, Selvin E. Association of diabetes, comorbidities, and A1C with functional disability in older adults: results from the National Health and Nutrition Examination Survey (NHANES), 1999-2006. Diabetes Care. 2010 May;33(5):1055-60.
- 3. Kalyani RR, Franco M, Dobs AS, Ouyang P, Vaidya D, Bertoni A, Gapstur SM, Golden SH. The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women. J Clin Endocrinol Metab. 2009 Nov;94(11):4127-35.
- 4. Saudek CD, Kalyani RR. Does comorbidity affect the benefit of intensive glycemic control in older patients with type 2 diabetes mellitus? Nat Clin Pract Endocrinol Metab. 2009 Feb;5(2):78
- 5. Kalyani RR, Metter EJ, Ramachandran R, Chia C, Saudek CD, Ferrucci L. Glucose and insulin measurements from the oral glucose tolerance test and relationship to muscle mass. Journal of Gerontology: Medical Sciences. 2011; 24 Feb [epub ahead of print.]