Research

Research interests

Dr. Brown’s research focuses on metabolic, endocrine, and skeletal abnormalities observed in HIV-infected patients, particularly as related to aging. He is a co-investigator in the Multicenter AIDS Cohort Study and the AIDS Clinical Trial Group. Through multiple ongoing epidemiologic studies and clinical trials, he has been interested in clarifying the epidemiology, pathogenesis, optimal treatment, and clinical consequences of insulin resistance/diabetes, body composition abnormalities, osteoporosis, and hypogonadism in HIV-infected patients. In particular, he has been interested in the relative contributions of antiretroviral therapies and chronic inflammation in the pathogenesis of these disorders.

Recent publications 

• Brown TT. Approach to the human immunodeficiency virus-infected patient with lipodystrophy. J Clin Endocrinol Metab. 2008 Aug;93(8):2937-45.
  
  
• Brown TT, McComsey GA, King MS, Qaqish RB, Bernstein BM, da Silva B, Loss of Bone Mineral Density after Antiretroviral Therapy Initiation, Independent of Antiretroviral Regimen, JAIDS, 2009, 51(5):554-61
  
  
• Brown TT, Mehta SH, Sutcliffe, C, Higgins Y, Torbenson MS, Moore RD, Thomas DL, Sulkowski MS, Hepatic Steatosis Associated with Increased Central Body Fat by Dual-Energy X-ray Absorptiometry and Uncontrolled HIV in HIV/Hepatitis C Co-infected Persons, AIDS, 2010, 24(6):811-7
  
  
• Brown TT, McComsey GA, Association between Initiation of Antiretroviral Therapy with Efavirenz and Decreases in 25 Hydroxyvitamin D, Antiviral Therapy, 2010, 15(3):425-9
  
  
• El-Maouche D, Xu X, Cofrancesco J, Dobs AS, Brown TT, Prevalence of Low Bone Mineral Density in a Low-Income Inner-City Population, Journal of Bone and Mineral Research, 2010, in press
  
  
• Brown TT, Tassiopoulos K, Shikuma C, McComsey GA, Association between Systemic Inflammation and Incident Diabetes Mellitus in HIV-infected Patients after Initiation of Antiretroviral Therapy, Diabetes Care, 2010, Oct;33(10):2244-9
  
  
•  McComsey GA, Tebas P, Shane E, Yin MT, Overton ET, Huang JS, Aldrovandi GM, Cardoso SW,Santana JL, Brown TT, Bone disease in HIV: A practical review and recommendations for HIV providers, Clinical Infectious Disease, 2010, Oct 15;51(8):937-46