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Dr. Klein is an assistant professor in the Center for Advanced Modeling in the Social, Behavioral and Health Sciences (CAM) in the Department of Emergency Medicine. He is also a fellow at the Center for Disease Dynamics, Economics and Policy, in Washington, D.C. Upon finishing his PhD in ecology and evolutionary biology from Princeton University, Dr. Klein joined the Hopkins faculty in 2012.
Dr. Klein’s research focuses on the role of individual behavior in the spread of infectious diseases. This area of research sits at the nexus of economics and epidemiology, and is premised on the idea of incorporating incentives for healthy behavior and their attendant behavioral responses into an epidemiological context to better understand how diseases are transmitted and how they can be controlled. This nascent field of economic epidemiology is based on the idea of improving policy responses to epidemic diseases by giving policymakers and health-care providers clear tools for thinking about how certain actions can influence disease transmission.
Dr. Klein has authored numerous publications on the evolution and spread of antimicrobial drug-resistance, with particular reference to the emergence of antibiotic and antimalarial drug resistance. Dr. Klein is actively involved in research efforts examining the ecology and epidemiology of antibiotic resistance in the United States, focusing on aspects of the emergence, spread, and economic impact of important pathogens such as methicillin-resistant Staphylococcus aureus, carbapenem-resistant Klebsiella pneumoniae, vancomycin-resistant enterococci, and Clostridium difficile. In addition, he is also actively engaged in understanding the impact of seasonal changes in antibiotic prescriptions on changes in resistance levels, and how the interaction between the hospital and the community influences different strains of resistance. Dr. Klein also has active research programs dealing with the emergence and spread of anti-malarial drug resistance as well as research on the role transboundary transmission of tuberculosis (TB), with a particular focus on drug-resistance forms of TB, plays in the epidemiology and economic impact of TB.