Title(s):
Assistant Professor of Radiation Oncology and Molecular Radiation Sciences
Assistant Professor of Oncology
Assistant Professor of Oncology
Appointment Phone:
410-502-8000
Primary Location:
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Expertise:
Esophageal Cancer, Lung Cancer, Mesothelioma, Non-Small Cell Lung Cancer, Radiation Oncology, Small Cell Lung Cancer, Stereotactic Ablative Radiotherapy, Stereotactic Body Radiation Therapy, Thymoma
Education and Experience
Training
- Johns Hopkins University School of Medicine (Baltimore MD)/ (2005)
Residencies
- The Johns Hopkins Hospital (Baltimore MD)/ Radiation Oncology (2010)
Certifications
- Radiation Oncology, American Board of Radiology (2011)
Locations
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
401 N. Broadway
Baltimore, MD 21231
Phone: 410-955-7390
Appointment Phone: 410-502-8000
Location Map
Johns Hopkins Bayview Medical Center
4940 Eastern Avenue
Baltimore, MD 21224
Phone: 410-955-7390
Appointment Phone: 410-502-8000
Location Map
Department / Division
- Radiation Oncology and Molecular Radiation Sciences
Centers/Institutes
Centers / Institutes
- Esophageal Cancer Program
- Sidney Kimmel Comprehensive Cancer Center
Bio
Biography
Dr. Russell Hales focuses clinical and research efforts on thoracic malignancies in the department of radiation oncology. As the director of thoracic multidisciplinary clinic, he helps to provide an expedited treatment recommendation and counseling for patients with newly diagnosed lung and esophagus cancer by all specialists in one office visit. He is involved in the development of the Lung Cancer Center of Excellence.
Prior to joining the faculty, Dr. Hales completed a B.S. at Brigham Young University and graduated valedictorian and summa cum laude. He received his medical degree at the Johns Hopkins University School of Medicine, completed internship on the Osler Medical Service, and residency in the Department of Radiation Oncology and Molecular Radiation sciences at Johns Hopkins.
Prior to joining the faculty, Dr. Hales completed a B.S. at Brigham Young University and graduated valedictorian and summa cum laude. He received his medical degree at the Johns Hopkins University School of Medicine, completed internship on the Osler Medical Service, and residency in the Department of Radiation Oncology and Molecular Radiation sciences at Johns Hopkins.
Expertise
- Esophageal Cancer
- Lung Cancer
- Mesothelioma
- Non-Small Cell Lung Cancer
- Radiation Oncology
- Small Cell Lung Cancer
- Stereotactic Ablative Radiotherapy
- Stereotactic Body Radiation Therapy
- Thymoma
Research
Research and Publications
Dr. Hales research activities focus on improving the effectiveness of radiation therapy for patients with lung and esophagus cancer. His interests bridge pre-clinical models of cancer treatment with innovative therapies. By exploring the effects of hedgehog pathway signaling on tumor response to radiation treatment, Dr. Hales research group is translating pre-clinical discovery to clinical trials to improve outcomes in patients needing radiation treatment.
He also evaluates new radiation technologies and their use in patients with lung cancer. For example, 4D MRI is being investigated as a means of more accurately tracking tumor motion with breathing, which results in improved targeting of tumor. He is also analyzes the benefit of daily image guidance in patients undergoing radiation therapy. Predictive models are being created which help personalize need for image guidance in patients undergoing therapy.
Jing Zeng, Khaled Aziz, Blake Aftab, Michael Armour, Sivarajan T. Chettiar, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. Clinical Cancer Research, Under Review Jan 2012.
Teboh Roland, Russell Hales, Todd McNutt, John Wong, Patricio Simari, Erik Tryggestad. A method for deriving a 4D-interpolated balanced planning target for mobile tumors. Medical Physics 2012 Jan 39 (1): 195-205.
Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gujula, Michael Armour, Jillian Phallen, Stephanie Terezakis, Lawrence Kleinberg, Kristen Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quinones-Hinojosa, Phuoc T. Tran, Michael Lim. Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 2011 Oct 1 (7): 657-73.
Phuoc T. Tran, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettair, Rachit Kumar, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Under Review 2011
Russell Hales, Moody Wharam. Pediatric High-Grade Glioma: Clinical, Treatment-Related, and
Biologic Prognostic Factors, Accepted for Publication, European Journal of Clinical & Medical
Oncology July 2011.
Husain H, Hann C, Hales R Radiotherapy in small-cell lung cancer. Oncology. 2010 Oct, 24 (11): 1047-1049.
Hales, R.K. Bachereau, J. Ribas, A. Tarhini, A.A. Weber, J.S. Fox, B.A. and Drake, C.G. Assessing Oncologic Benefit in Clinical Trials of Immunotherapy Agents. Annals of Oncology. 2010 Oct; 21 (10): 1944-1941.
Hales, R.K. Shokek, O. Burger, P.C. Paynter, N.P. Chaichana, K.L. Quiones-Hinojosa, A. Jallo, G.I., Cohen, K.J. Song, D.Y. Carson, B.S. and Wharam M.D. Prognostic Factors in Pediatric High-Grade Astrocytoma: The Importance of Accurate Pathologic Diagnosis. J Neurooncol. 2010 Aug; 99 (1): 65-71.
Holmes, K.W. Hales, R.K. Chu, S. Maxwell, M.J. Mogayzel, P.J. Zeitlin, P.L. Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression. American Journal of Respiratory Cell and Molecular Biology, 29: 499-505, 2003.
He also evaluates new radiation technologies and their use in patients with lung cancer. For example, 4D MRI is being investigated as a means of more accurately tracking tumor motion with breathing, which results in improved targeting of tumor. He is also analyzes the benefit of daily image guidance in patients undergoing radiation therapy. Predictive models are being created which help personalize need for image guidance in patients undergoing therapy.
Jing Zeng, Khaled Aziz, Blake Aftab, Michael Armour, Sivarajan T. Chettiar, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. Clinical Cancer Research, Under Review Jan 2012.
Teboh Roland, Russell Hales, Todd McNutt, John Wong, Patricio Simari, Erik Tryggestad. A method for deriving a 4D-interpolated balanced planning target for mobile tumors. Medical Physics 2012 Jan 39 (1): 195-205.
Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gujula, Michael Armour, Jillian Phallen, Stephanie Terezakis, Lawrence Kleinberg, Kristen Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quinones-Hinojosa, Phuoc T. Tran, Michael Lim. Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 2011 Oct 1 (7): 657-73.
Phuoc T. Tran, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettair, Rachit Kumar, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Under Review 2011
Russell Hales, Moody Wharam. Pediatric High-Grade Glioma: Clinical, Treatment-Related, and
Biologic Prognostic Factors, Accepted for Publication, European Journal of Clinical & Medical
Oncology July 2011.
Husain H, Hann C, Hales R Radiotherapy in small-cell lung cancer. Oncology. 2010 Oct, 24 (11): 1047-1049.
Hales, R.K. Bachereau, J. Ribas, A. Tarhini, A.A. Weber, J.S. Fox, B.A. and Drake, C.G. Assessing Oncologic Benefit in Clinical Trials of Immunotherapy Agents. Annals of Oncology. 2010 Oct; 21 (10): 1944-1941.
Hales, R.K. Shokek, O. Burger, P.C. Paynter, N.P. Chaichana, K.L. Quiones-Hinojosa, A. Jallo, G.I., Cohen, K.J. Song, D.Y. Carson, B.S. and Wharam M.D. Prognostic Factors in Pediatric High-Grade Astrocytoma: The Importance of Accurate Pathologic Diagnosis. J Neurooncol. 2010 Aug; 99 (1): 65-71.
Holmes, K.W. Hales, R.K. Chu, S. Maxwell, M.J. Mogayzel, P.J. Zeitlin, P.L. Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression. American Journal of Respiratory Cell and Molecular Biology, 29: 499-505, 2003.
Research Interests
- Characterization of organ motion in thoracic tumors
- Novel radiation sensitizers in non small cell lung cancer
More Info
Languages
- English
Additional Resources
Johns Hopkins Radiation Oncology and Molecular Sciences
The Sidney Kimmel Comprehensive Cancer Center
Esophageal Cancer Program
Lung Cancer Program
The Sidney Kimmel Comprehensive Cancer Center
Esophageal Cancer Program
Lung Cancer Program
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