Phuoc Tho Tran, MD PhD
Title(s): Assistant Professor of Radiation Oncology and Molecular Radiation Sciences
Assistant Professor of Oncology
Assistant Professor of Urology
Assistant Professor of Oncology
Assistant Professor of Urology
Appointment Phone:
410-502-8000
Primary Location:
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Expertise:
Adrenal Cancer, Bladder Cancer, Bone Cancer, Image-Guided Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Metastatic Bone Disease, Metastatic Disease, Oligometastatic Disease, Penile Cancer, Prostate Brachytherapy, Prostate Cancer, Radiation Oncology, Stereotactic Body Radiation Therapy, Testicular Cancer, Urethral Cancer
Education and Experience
Training
- Oregon Health & Sciences University (Portland OR)/ (2003)
Residencies
- Stanford University School of Medicine (Stanford CA)/ Radiation Oncology (2008)
Certifications
- Radiation Oncology, American Board of Radiology (2009)
Locations
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
401 N. Broadway
Baltimore, MD 21231
Phone: 410-614-6477
Appointment Phone: 410-502-8000
Fax: 410-502-2821
Location Map
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Appointment Phone: 410-502-8000
Location Map
Department / Division
- Radiation Oncology and Molecular Radiation Sciences
Centers/Institutes
Centers / Institutes
- Sidney Kimmel Comprehensive Cancer Center
Bio
Biography
Dr. Tran and his laboratory focus their studies on the transitions between epithelial and mesenchymal cellular states and the implications of these transitions for tumorigenesis, cancer treatment resistance and radiation-induced fibrosis primarily through the use of transgenic mouse models. One of these transitions known as epithelial-mesenchymal transition (EMT) is a conserved developmental program that when inappropriately activated in post-natal life has been associated with organ fibrosis, tumorigenesis and metastasis.
A major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation induced late effects. Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.
Clinically Dr. Tran treats patients with cancers of the genitourinary system and uses stereotactic radiation techniques (such as SRS and SBRT/SABR) for the treatment of patients with oligometastatic disease. The Tran lab is committed to translating discoveries from the laboratory bench into novel cancer prevention, diagnostic and treatment approaches that can be tested in the clinic.
A major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation induced late effects. Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.
Clinically Dr. Tran treats patients with cancers of the genitourinary system and uses stereotactic radiation techniques (such as SRS and SBRT/SABR) for the treatment of patients with oligometastatic disease. The Tran lab is committed to translating discoveries from the laboratory bench into novel cancer prevention, diagnostic and treatment approaches that can be tested in the clinic.
Awards and Honors
1995 John Muir College Caledonian Honor Society, UCSD.
1995-1996 UC Regents Scholar.
1996 Graduated magna cum laude from UCSD.
1996-2003 OHSU Laurel Merit MD/PhD Scholar.
1998-2001 OHSU Molecular Hematology Research Training Fellow (NIH grant 5-T32-HL07781).
2003 OHSU Deans Medical Student Research Award recipient.
2006 Radiological Society of North America (RSNA) Roentgen Resident Research Award.
2006 RSNA Research Resident (RR0601).
2007 ASCO/AACR Methods in Clinical Cancer Research Workshop Scholarship.
2007 Malcolm A. Bagshaw Award.
2007 Henry S. Kaplan Research Fellow (SUMC grant 1046297-100-KAVWO).
2008 RSNA Research Fellow (RF0801).
2008-2011 Parker B. Francis Fellow.
2009-2011 ASTRO Junior Faculty Career Research Training Award.
2011-2013 The Phyllis and Brian L. Harvey Scholar - Patrick C. Walsh Prostate Cancer Research Fund Award.
2011-2016 DoD Prostate Cancer Physician Research Training Award (PC101555).
2012 Association of Residents in Radiation Oncology (ARRO) Educator of the Year.
2012 Top Doctors by Baltimore Magazine.
2012-2014 Uniting Against Lung Cancer Junior Investigator Award.
2012-2016 American Cancer Society Research Scholar.
2013 OHSU SOM Alumni Association Early Career Achievement Award (Inaugural Award).
1995-1996 UC Regents Scholar.
1996 Graduated magna cum laude from UCSD.
1996-2003 OHSU Laurel Merit MD/PhD Scholar.
1998-2001 OHSU Molecular Hematology Research Training Fellow (NIH grant 5-T32-HL07781).
2003 OHSU Deans Medical Student Research Award recipient.
2006 Radiological Society of North America (RSNA) Roentgen Resident Research Award.
2006 RSNA Research Resident (RR0601).
2007 ASCO/AACR Methods in Clinical Cancer Research Workshop Scholarship.
2007 Malcolm A. Bagshaw Award.
2007 Henry S. Kaplan Research Fellow (SUMC grant 1046297-100-KAVWO).
2008 RSNA Research Fellow (RF0801).
2008-2011 Parker B. Francis Fellow.
2009-2011 ASTRO Junior Faculty Career Research Training Award.
2011-2013 The Phyllis and Brian L. Harvey Scholar - Patrick C. Walsh Prostate Cancer Research Fund Award.
2011-2016 DoD Prostate Cancer Physician Research Training Award (PC101555).
2012 Association of Residents in Radiation Oncology (ARRO) Educator of the Year.
2012 Top Doctors by Baltimore Magazine.
2012-2014 Uniting Against Lung Cancer Junior Investigator Award.
2012-2016 American Cancer Society Research Scholar.
2013 OHSU SOM Alumni Association Early Career Achievement Award (Inaugural Award).
Expertise
- Adrenal Cancer
- Bladder Cancer
- Bone Cancer
- Image-Guided Radiation Therapy
- Intensity-Modulated Radiation Therapy (IMRT)
- Metastatic Bone Disease
- Metastatic Disease
- Oligometastatic Disease
- Penile Cancer
- Prostate Brachytherapy
- Prostate Cancer
- Radiation Oncology
- Stereotactic Body Radiation Therapy
- Testicular Cancer
- Urethral Cancer
Research
Research and Publications
Phuoc T. Tran*, Julien Fey*, Naz Erdeniz*, Lionel Gellon, Serge Boiteux and R. Michael Liskay. A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair. DNA Repair 6 (2007) 1572-1583.
* - these authors contributed equally.
Phuoc T. Tran*, Wendy Hara*, Zheng Su, H. Jill Lin, Pavan K. Bendapudi, Jeffrey Norton, Nelson Teng, Christopher R. King & Daniel S. Kapp. Intraoperative Radiation Therapy for Locally Advanced and Recurrent Soft Tissue Sarcomas in Adults. Int J Radiat Oncol Biol Phys. 72 (2008) 1146-1153.
* - these authors contributed equally.
Phuoc T. Tran*, Alice C. Fan*, Pavan K. Bendapudi*, Shan Koh, Kim Komatsubara, Joy Chen, George Horng, David I. Bellovin, Sylvie Giuriato, Craig S. Wang, Jeffrey A. Whitsett and Dean W. Felsher. Combined Inactivation of MYC and K-RasOncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas. PLoS ONE 3 (2008) e2125.
* - these authors contributed equally.
Wendy Hara, Phuoc Tran, Gordon Li, Zheng Su, Putipun Puataweepong, John Adler, Steven Chang, Scott Soltys and Iris C. Gibbs. Cyberknife for brain metastases of malignant melanoma and renal cell carcinoma. Neurosurgery 64 (2009) A26-32.
Melissa Horoschak, Phuoc T. Tran*, Pavan Bachireddy, Robert B. West, David Mohler, Christopher Beaulieu, Daniel S. Kapp, and Sarah S. Donaldson. External beam radiation therapy enhances local control in pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 75 (2009) 183-187.
* - corresponding author.
Hu Zhou, Manuel Rodriguez, Fred van den Haak, Geoffrey Nelson, Rahil Jogani, Jiali Xu, Xinzhi Zhu, Yongjiang Xian, Phuoc T. Tran, Dean W. Felsher, Paul J. Keall, Edward E. Graves. Development of a MicroCT-Based Image-Guided Conformal Radiotherapy System for Small Animals. Int J Radiat Oncol Biol Phys 78 (2010) 297-305.
Pavan Bachireddy*, Diane Tseng*, Melissa Horoschak, Daniel T. Chang, Albert C. Koong, Daniel S. Kapp, Phuoc T. Tran. Orthovoltage intraoperative radiation therapy for pancreatic adenocarincoma. Radiat Oncol 5 (2010) 105.
* - these authors contributed equally.
Alfred P. See*, Jing Zeng*, Phuoc T. Tran+, and Michael Lim+. Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series. Radiat Oncol 6 (2011) 25. PMID: 21414215; PMCID: PMC3064638.
* - these authors contributed equally; and + - corresponding authors.
Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gujula, Michael Armour, Jillian Phallen, Stephanie Terezakis, Lawrence Kleinberg, Kristen Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quinones-Hinojosa, Phuoc T. Tran+, Michael Lim+. Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 12 (2011) 657-63.
+ - corresponding authors
Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, Peter Choi, Shan Koh, Joy Chen, George Horng, Nicholas P. Hughes, Lawrence H. Schwartz, Vincent A. Miller, Toshiyuki Kawashima, Toshio Kitamura, David Paik+ and Dean W. Felsher+. Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation. Sci Transl Med 3 (2011) 103ra99**.
* - these authors contributed equally; and + - corresponding authors
** - Highlighted by Comments in Sci Transl Med, Cancer Res, Nat Rev Clin Oncol and Cancer Discovery.
Diane Tseng*, Leeland P. Rachakonda*, Zheng Su, Ranjana Advani, Sandra Horning, Richard T. Hoppe, Andrew Quon, Edward E. Graves, Billy W. Loo, Jr, Phuoc T. Tran. Interim-treatment quantitative PET parameters predict progression and death among patients with Hodgkin's Disease. Radiat Oncol 7 (2012) 5.
* - these authors contributed equally
Phuoc T. Tran+, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettiar, Nishant Gandhi, Aaron T. Wild, Rachit Kumar, Joseph M. Herman, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Curr Mol Med 12 (2012) 772-787.
+ - corresponding author
Nicholas Trakul, Christine Chang, Jeremy Harris, Christopher H. Chapman, Aarti Rao, John Shen, Sean Quinlan-Davidson, Edith J. Filion, Heather Wakelee, A. Dimitrios Colevas, Richard I. Whyte, Sonja Dieterich, Peter G. Maxim, Phuoc Tran, Quynh-Thu Le, Billy W. Loo, Jr., Maximilian Diehn. Tumor volume-adapted dosing in stereotactic ablative radiotherapy of lung tumors. Int J Radiat Oncol Biol Phys 84 (2012) 231-7.
Phuoc T. Tran*+, Emelyn H. Shroff*, Timothy F. Burns*, Saravanan Thiyagarajan, Sandhya T. Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J. Adam, Silvestre Vicent, Carsten H. Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S. Gambhir, Charles M. Rudin and Dean W. Felsher+. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8 (2012) e1002650.
* - these authors contributed equally; and + - corresponding authors
Nishant Gandhi*, Aaron T. Wild*, Sivarajan T. Chettiar, Khaled Aziz, Yoshinori Kato, Rajendra P. Gajula, Russell D. Williams, Jessica Cades, Anvesh Annadanam, Danny Song, Yonggang Zhang, Russell K. Hales, Joseph M. Herman, Theodore L. DeWeese, Edward M. Schaeffer, Phuoc T. Tran. Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells. Cancer Biol Ther 14 (2013) In press.
Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah S. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, and Charles M. Rudin. Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer. Mol Cancer Res (2013) In press.
* - these authors contributed equally.
Phuoc T. Tran*, Wendy Hara*, Zheng Su, H. Jill Lin, Pavan K. Bendapudi, Jeffrey Norton, Nelson Teng, Christopher R. King & Daniel S. Kapp. Intraoperative Radiation Therapy for Locally Advanced and Recurrent Soft Tissue Sarcomas in Adults. Int J Radiat Oncol Biol Phys. 72 (2008) 1146-1153.
* - these authors contributed equally.
Phuoc T. Tran*, Alice C. Fan*, Pavan K. Bendapudi*, Shan Koh, Kim Komatsubara, Joy Chen, George Horng, David I. Bellovin, Sylvie Giuriato, Craig S. Wang, Jeffrey A. Whitsett and Dean W. Felsher. Combined Inactivation of MYC and K-RasOncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas. PLoS ONE 3 (2008) e2125.
* - these authors contributed equally.
Wendy Hara, Phuoc Tran, Gordon Li, Zheng Su, Putipun Puataweepong, John Adler, Steven Chang, Scott Soltys and Iris C. Gibbs. Cyberknife for brain metastases of malignant melanoma and renal cell carcinoma. Neurosurgery 64 (2009) A26-32.
Melissa Horoschak, Phuoc T. Tran*, Pavan Bachireddy, Robert B. West, David Mohler, Christopher Beaulieu, Daniel S. Kapp, and Sarah S. Donaldson. External beam radiation therapy enhances local control in pigmented villonodular synovitis. Int J Radiat Oncol Biol Phys. 75 (2009) 183-187.
* - corresponding author.
Hu Zhou, Manuel Rodriguez, Fred van den Haak, Geoffrey Nelson, Rahil Jogani, Jiali Xu, Xinzhi Zhu, Yongjiang Xian, Phuoc T. Tran, Dean W. Felsher, Paul J. Keall, Edward E. Graves. Development of a MicroCT-Based Image-Guided Conformal Radiotherapy System for Small Animals. Int J Radiat Oncol Biol Phys 78 (2010) 297-305.
Pavan Bachireddy*, Diane Tseng*, Melissa Horoschak, Daniel T. Chang, Albert C. Koong, Daniel S. Kapp, Phuoc T. Tran. Orthovoltage intraoperative radiation therapy for pancreatic adenocarincoma. Radiat Oncol 5 (2010) 105.
* - these authors contributed equally.
Alfred P. See*, Jing Zeng*, Phuoc T. Tran+, and Michael Lim+. Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series. Radiat Oncol 6 (2011) 25. PMID: 21414215; PMCID: PMC3064638.
* - these authors contributed equally; and + - corresponding authors.
Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gujula, Michael Armour, Jillian Phallen, Stephanie Terezakis, Lawrence Kleinberg, Kristen Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quinones-Hinojosa, Phuoc T. Tran+, Michael Lim+. Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 12 (2011) 657-63.
+ - corresponding authors
Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, Peter Choi, Shan Koh, Joy Chen, George Horng, Nicholas P. Hughes, Lawrence H. Schwartz, Vincent A. Miller, Toshiyuki Kawashima, Toshio Kitamura, David Paik+ and Dean W. Felsher+. Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation. Sci Transl Med 3 (2011) 103ra99**.
* - these authors contributed equally; and + - corresponding authors
** - Highlighted by Comments in Sci Transl Med, Cancer Res, Nat Rev Clin Oncol and Cancer Discovery.
Diane Tseng*, Leeland P. Rachakonda*, Zheng Su, Ranjana Advani, Sandra Horning, Richard T. Hoppe, Andrew Quon, Edward E. Graves, Billy W. Loo, Jr, Phuoc T. Tran. Interim-treatment quantitative PET parameters predict progression and death among patients with Hodgkin's Disease. Radiat Oncol 7 (2012) 5.
* - these authors contributed equally
Phuoc T. Tran+, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettiar, Nishant Gandhi, Aaron T. Wild, Rachit Kumar, Joseph M. Herman, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Curr Mol Med 12 (2012) 772-787.
+ - corresponding author
Nicholas Trakul, Christine Chang, Jeremy Harris, Christopher H. Chapman, Aarti Rao, John Shen, Sean Quinlan-Davidson, Edith J. Filion, Heather Wakelee, A. Dimitrios Colevas, Richard I. Whyte, Sonja Dieterich, Peter G. Maxim, Phuoc Tran, Quynh-Thu Le, Billy W. Loo, Jr., Maximilian Diehn. Tumor volume-adapted dosing in stereotactic ablative radiotherapy of lung tumors. Int J Radiat Oncol Biol Phys 84 (2012) 231-7.
Phuoc T. Tran*+, Emelyn H. Shroff*, Timothy F. Burns*, Saravanan Thiyagarajan, Sandhya T. Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J. Adam, Silvestre Vicent, Carsten H. Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S. Gambhir, Charles M. Rudin and Dean W. Felsher+. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8 (2012) e1002650.
* - these authors contributed equally; and + - corresponding authors
Nishant Gandhi*, Aaron T. Wild*, Sivarajan T. Chettiar, Khaled Aziz, Yoshinori Kato, Rajendra P. Gajula, Russell D. Williams, Jessica Cades, Anvesh Annadanam, Danny Song, Yonggang Zhang, Russell K. Hales, Joseph M. Herman, Theodore L. DeWeese, Edward M. Schaeffer, Phuoc T. Tran. Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells. Cancer Biol Ther 14 (2013) In press.
Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah S. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, and Charles M. Rudin. Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer. Mol Cancer Res (2013) In press.
Research Interests
- Radiosensitizers
- Genetically engineered mouse models of disease
- Epithelial-Mesenchymal Transition (EMT)
More Info
Languages
- English
Memberships
2004- ASTRO (Member ID#35173018)
2004- RSNA (Member ID #00374305)
2004- American College of Radiology (ACR) (Member ID #05043345)
2005- American College of Radiation Oncology (ACRO)
2007- American Society of Clinical Oncology (ASCO) (Member ID #81970)
2007- American Association for Cancer Research (AACR) (Member ID #140253)
2008- American Thoracic Society (ATS) (Member ID #00115427)
2011- The EMT International Association (Member ID #23294)
2011- Radiation Research Society (RRS) (Member ID #00291116)
2004- RSNA (Member ID #00374305)
2004- American College of Radiology (ACR) (Member ID #05043345)
2005- American College of Radiation Oncology (ACRO)
2007- American Society of Clinical Oncology (ASCO) (Member ID #81970)
2007- American Association for Cancer Research (AACR) (Member ID #140253)
2008- American Thoracic Society (ATS) (Member ID #00115427)
2011- The EMT International Association (Member ID #23294)
2011- Radiation Research Society (RRS) (Member ID #00291116)
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