Title(s):
Assistant Professor of Neurological Surgery
Assistant Professor of Oncology
Assistant Professor of Radiation Oncology and Molecular Radiation Sciences
Assistant Professor of Oncology
Assistant Professor of Radiation Oncology and Molecular Radiation Sciences
Director of Brain Tumor Immunotherapy
Director of the Metastatic Brain Tumor Center
Director of the Metastatic Brain Tumor Center
Appointment Phone:
410-614-1627
Primary Location:
The Johns Hopkins Hospital
Expertise:
Arteriovenous Malformations, Brain Cancer, Brain Tumors, Metastatic Brain Tumors, Neurosurgery, Neurosurgical Oncology, Radiosurgery, Skull Base Surgery, Skull Base Tumors, Trigeminal Neuralgia
Education and Experience
Training
- Johns Hopkins University School of Medicine (Baltimore MD)/ (2000)
Residencies
- Stanford University School of Medicine (Stanford CA)/ Neurosurgery (2007)
Certifications
- Neurological Surgery, American Board of Neurological Surgery (2012)
Locations
The Johns Hopkins Hospital
600 N. Wolfe Street
Phipps Room 123
Baltimore, MD 21287
Phone: 410-614-1627
Appointment Phone: 410-614-1627
Fax: 410-502-4954
Location Map
Johns Hopkins Outpatient Center
601 N. Caroline Street
Baltimore, MD 21287
Appointment Phone: 410-955-6406
Location Map
Johns Hopkins Bayview Medical Center
4940 Eastern Avenue
Baltimore, MD 21224
Appointment Phone: 410-550-0465
Location Map
Department / Division
-
Neurosurgery - Neuro-Oncology
Centers/Institutes
Centers / Institutes
- Brain Tumor Center
- Cancer Immunology Center
- Pituitary Center
- Radiosurgery Center
- Sidney Kimmel Comprehensive Cancer Center
Bio
Biography
Dr. Michael Lim's surgical interest is in the treatment of primary and metastatic brain tumors as well as pituitary and skull base tumors. He also has an interest in surgical treatments of trigeminal neuralgia. He utilizes the most advanced techniques in neurosurgery including image guided surgery, microsurgery, minimally invasive techniques, and endoscopic surgery.
Dr. Lim also possesses expertise in radiosurgery. He is the Director of the Spine Radiosurgery program. In addition to treating spinal tumors, he is an expert in the treatment of brain tumors, arteriovenous malformations, and trigeminal neuralgia with radiosurgery.
Dr. Lim's primary research interest involves immune-based therapies against brain tumors. His research focuses on understanding the mechanisms of immune evasion by primary brain tumors with the goal of translation to novel therapies against gliomas. Dr. Lim also performs clinical research. He publishes extensively in radiosurgery and also has interests in brain tumor clinical trials for which he works closely with the neuro-oncologists in a team approach.
Dr. Lim also possesses expertise in radiosurgery. He is the Director of the Spine Radiosurgery program. In addition to treating spinal tumors, he is an expert in the treatment of brain tumors, arteriovenous malformations, and trigeminal neuralgia with radiosurgery.
Dr. Lim's primary research interest involves immune-based therapies against brain tumors. His research focuses on understanding the mechanisms of immune evasion by primary brain tumors with the goal of translation to novel therapies against gliomas. Dr. Lim also performs clinical research. He publishes extensively in radiosurgery and also has interests in brain tumor clinical trials for which he works closely with the neuro-oncologists in a team approach.
Physician Title
Director of Brain Tumor Immunotherapy
Director of the Metastatic Brain Tumor Center
Director of the Metastatic Brain Tumor Center
Expertise
- Arteriovenous Malformations
- Brain Cancer
- Brain Tumors
- Metastatic Brain Tumors
- Neurosurgery
- Neurosurgical Oncology
- Radiosurgery
- Skull Base Surgery
- Skull Base Tumors
- Trigeminal Neuralgia
Research
Research and Publications
1.Factors associated with survival for patients with glioblastoma with poor pre-operative functional status.
Chaichana KL, Martinez-Gutierrez JC, De la Garza-Ramos R, Weingart JD, Olivi A, Gallia GL, Lim M, Brem H, Quinones-Hinojosa A.
J Clin Neurosci. 2013 Jun;20(6):818-23. doi: 10.1016/j.jocn.2012.07.016. Epub 2013 Apr 29.
2.Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection.
Chen L, Guerrero-Cazares H, Ye X, Ford E, McNutt T, Kleinberg L, Lim M, Chaichana K, Quinones-Hinojosa A, Redmond K.
Int J Radiat Oncol Biol Phys. 2013 Mar 26. doi:pii: S0360-3016(13)00182-X. 10.1016/j.ijrobp.2013.02.014. [Epub ahead of print]
3.Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas.
Zeng J, See AP, Phallen J, Jackson CM, Belcaid Z, Ruzevick J, Durham N, Meyer C, Harris TJ, Albesiano E, Pradilla G, Ford E, Wong J, Hammers HJ, Mathios D, Tyler B, Brem H, Tran PT, Pardoll D, Drake CG, Lim M.
Int J Radiat Oncol Biol Phys. 2013 Jun 1;86(2):343-9. doi: 10.1016/j.ijrobp.2012.12.025. Epub 2013 Feb 22.
4.Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement.
Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J, Barker PB, van Zijl PC, Blakeley JO.
J Magn Reson Imaging. 2013 Feb 25. doi: 10.1002/jmri.24067. [Epub ahead of print]
5.Vaccine strategies for glioblastoma: progress and future directions.
Jackson C, Ruzevick J, Brem H, Lim M.
Immunotherapy. 2013 Feb;5(2):155-67. doi: 10.2217/imt.12.155.
6.Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors.
Chaichana KL, Pendleton C, Jackson C, Martinez-Gutierrez JC, Diaz-Stransky A, Aguayo J, Olivi A, Weingart J, Gallia G, Lim M, Brem H, Quinones-Hinojosa A.
Neurol Res. 2013 Mar;35(2):206-11. doi: 10.1179/1743132812Y.0000000126. Epub 2012 Dec 13.
7.Glycerol rhizotomy and radiofrequency thermocoagulation for trigeminal neuralgia in multiple sclerosis.
Bender M, Pradilla G, Batra S, See AP, James C, Pardo CA, Carson BS, Lim M.
J Neurosurg. 2013 Feb;118(2):329-36. doi: 10.3171/2012.9.JNS1226. Epub 2012 Nov 2.
8.The role of STAT3 activation in modulating the immune microenvironment of GBM.
See AP, Han JE, Phallen J, Binder Z, Gallia G, Pan F, Jinasena D, Jackson C, Belcaid Z, Jeong SJ, Gottschalk C, Zeng J, Ruzevick J, Nicholas S, Kim Y, Albesiano E, Pardoll DM, Lim M.
J Neurooncol. 2012 Dec;110(3):359-68. doi: 10.1007/s11060-012-0981-6. Epub 2012 Oct 25.
9.Multiple resections for patients with glioblastoma: prolonging survival.
Chaichana KL, Zadnik P, Weingart JD, Olivi A, Gallia GL, Blakeley J, Lim M, Brem H, Quiones-Hinojosa A.
J Neurosurg. 2013 Apr;118(4):812-20. doi: 10.3171/2012.9.JNS1277. Epub 2012 Oct 19.
10.Perspectives on key articles in neurosurgery.
Lim M, Sherman JH, Wang VY, Smith ZA, Cho JM, Colen CB, Kim CY, Zada G, Li G, Yang I.
Surg Neurol Int. 2012;3:58. doi: 10.4103/2152-7806.96869. Epub 2012 May 31. No abstract available.
11.Clinical trials with immunotherapy for high-grade glioma.
Ruzevick J, Jackson C, Phallen J, Lim M.
Neurosurg Clin N Am. 2012 Jul;23(3):459-70. doi: 10.1016/j.nec.2012.04.003. Epub 2012 Jun 8. Review.
12.Potential role for STAT3 inhibitors in glioblastoma.
Jackson C, Ruzevick J, Amin AG, Lim M.
Neurosurg Clin N Am. 2012 Jul;23(3):379-89. doi: 10.1016/j.nec.2012.04.002. Epub 2012 Jun 5. Review.
13.Subependymoma: clinical features and surgical outcomes.
Jain A, Amin AG, Jain P, Burger P, Jallo GI, Lim M, Bettegowda C.
Neurol Res. 2012 Sep;34(7):677-84. doi: 10.1179/1743132812Y.0000000064. Epub 2012 Jun 28. Review.
14.The Transconjunctival Transorbital Approach: A Keyhole Approach to the Midline Anterior Skull Base.
Raza SM, Quinones-Hinojosa A, Lim M, Boahene KD.
World Neurosurg. 2012 Jun 19. [Epub ahead of print]
15.Postoperative Anticoagulation in Patients with Mechanical Heart Valves Following Surgical Treatment of Subdural Hematomas.
Amin AG, Ng J, Hsu W, Pradilla G, Raza S, Quinones-Hinojosa A, Lim M.
Neurocrit Care. 2012 Apr 13. [Epub ahead of print]
16.Seizure control for patients undergoing meningioma surgery.
Chaichana KL, Pendleton C, Zaidi H, Olivi A, Weingart JD, Gallia GL, Lim M, Brem H, Quiones-Hinojosa A.
World Neurosurg. 2013 Mar-Apr;79(3-4):515-24. doi: 10.1016/j.wneu.2012.02.051. Epub 2012 Mar 30.
17.The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Lim M, Bower RS, Wang Y, Sims L, Bower MR, Camara-Quintana J, Li G, Cheshier S, Harsh GR 4th, Steinberg GK, Guccione S.
Neurosurg Rev. 2012 Jul;35(3):413-9; discussion 419. doi: 10.1007/s10143-012-0375-4. Epub 2012 Feb 28.
18.Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment.
Jackson C, Ruzevick J, Phallen J, Belcaid Z, Lim M.
Clin Dev Immunol. 2011;2011:732413. doi: 10.1155/2011/732413. Epub 2011 Dec 10. Review.
19.Stereotactic radiosurgery of cranial arteriovenous malformations and dural arteriovenous fistulas.
See AP, Raza S, Tamargo RJ, Lim M.
Neurosurg Clin N Am. 2012 Jan;23(1):133-46. doi: 10.1016/j.nec.2011.09.011. Review.
20.Effectiveness of repeat glycerol rhizotomy in treating recurrent trigeminal neuralgia.
Bender M, Pradilla G, Batra S, See A, Bhutiani N, James C, Carson BS, Lim M.
Neurosurgery. 2012 May;70(5):1125-33; discussion 1133-4. doi: 10.1227/NEU.0b013e31823f5eb6.
Chaichana KL, Martinez-Gutierrez JC, De la Garza-Ramos R, Weingart JD, Olivi A, Gallia GL, Lim M, Brem H, Quinones-Hinojosa A.
J Clin Neurosci. 2013 Jun;20(6):818-23. doi: 10.1016/j.jocn.2012.07.016. Epub 2013 Apr 29.
2.Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection.
Chen L, Guerrero-Cazares H, Ye X, Ford E, McNutt T, Kleinberg L, Lim M, Chaichana K, Quinones-Hinojosa A, Redmond K.
Int J Radiat Oncol Biol Phys. 2013 Mar 26. doi:pii: S0360-3016(13)00182-X. 10.1016/j.ijrobp.2013.02.014. [Epub ahead of print]
3.Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas.
Zeng J, See AP, Phallen J, Jackson CM, Belcaid Z, Ruzevick J, Durham N, Meyer C, Harris TJ, Albesiano E, Pradilla G, Ford E, Wong J, Hammers HJ, Mathios D, Tyler B, Brem H, Tran PT, Pardoll D, Drake CG, Lim M.
Int J Radiat Oncol Biol Phys. 2013 Jun 1;86(2):343-9. doi: 10.1016/j.ijrobp.2012.12.025. Epub 2013 Feb 22.
4.Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement.
Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J, Barker PB, van Zijl PC, Blakeley JO.
J Magn Reson Imaging. 2013 Feb 25. doi: 10.1002/jmri.24067. [Epub ahead of print]
5.Vaccine strategies for glioblastoma: progress and future directions.
Jackson C, Ruzevick J, Brem H, Lim M.
Immunotherapy. 2013 Feb;5(2):155-67. doi: 10.2217/imt.12.155.
6.Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors.
Chaichana KL, Pendleton C, Jackson C, Martinez-Gutierrez JC, Diaz-Stransky A, Aguayo J, Olivi A, Weingart J, Gallia G, Lim M, Brem H, Quinones-Hinojosa A.
Neurol Res. 2013 Mar;35(2):206-11. doi: 10.1179/1743132812Y.0000000126. Epub 2012 Dec 13.
7.Glycerol rhizotomy and radiofrequency thermocoagulation for trigeminal neuralgia in multiple sclerosis.
Bender M, Pradilla G, Batra S, See AP, James C, Pardo CA, Carson BS, Lim M.
J Neurosurg. 2013 Feb;118(2):329-36. doi: 10.3171/2012.9.JNS1226. Epub 2012 Nov 2.
8.The role of STAT3 activation in modulating the immune microenvironment of GBM.
See AP, Han JE, Phallen J, Binder Z, Gallia G, Pan F, Jinasena D, Jackson C, Belcaid Z, Jeong SJ, Gottschalk C, Zeng J, Ruzevick J, Nicholas S, Kim Y, Albesiano E, Pardoll DM, Lim M.
J Neurooncol. 2012 Dec;110(3):359-68. doi: 10.1007/s11060-012-0981-6. Epub 2012 Oct 25.
9.Multiple resections for patients with glioblastoma: prolonging survival.
Chaichana KL, Zadnik P, Weingart JD, Olivi A, Gallia GL, Blakeley J, Lim M, Brem H, Quiones-Hinojosa A.
J Neurosurg. 2013 Apr;118(4):812-20. doi: 10.3171/2012.9.JNS1277. Epub 2012 Oct 19.
10.Perspectives on key articles in neurosurgery.
Lim M, Sherman JH, Wang VY, Smith ZA, Cho JM, Colen CB, Kim CY, Zada G, Li G, Yang I.
Surg Neurol Int. 2012;3:58. doi: 10.4103/2152-7806.96869. Epub 2012 May 31. No abstract available.
11.Clinical trials with immunotherapy for high-grade glioma.
Ruzevick J, Jackson C, Phallen J, Lim M.
Neurosurg Clin N Am. 2012 Jul;23(3):459-70. doi: 10.1016/j.nec.2012.04.003. Epub 2012 Jun 8. Review.
12.Potential role for STAT3 inhibitors in glioblastoma.
Jackson C, Ruzevick J, Amin AG, Lim M.
Neurosurg Clin N Am. 2012 Jul;23(3):379-89. doi: 10.1016/j.nec.2012.04.002. Epub 2012 Jun 5. Review.
13.Subependymoma: clinical features and surgical outcomes.
Jain A, Amin AG, Jain P, Burger P, Jallo GI, Lim M, Bettegowda C.
Neurol Res. 2012 Sep;34(7):677-84. doi: 10.1179/1743132812Y.0000000064. Epub 2012 Jun 28. Review.
14.The Transconjunctival Transorbital Approach: A Keyhole Approach to the Midline Anterior Skull Base.
Raza SM, Quinones-Hinojosa A, Lim M, Boahene KD.
World Neurosurg. 2012 Jun 19. [Epub ahead of print]
15.Postoperative Anticoagulation in Patients with Mechanical Heart Valves Following Surgical Treatment of Subdural Hematomas.
Amin AG, Ng J, Hsu W, Pradilla G, Raza S, Quinones-Hinojosa A, Lim M.
Neurocrit Care. 2012 Apr 13. [Epub ahead of print]
16.Seizure control for patients undergoing meningioma surgery.
Chaichana KL, Pendleton C, Zaidi H, Olivi A, Weingart JD, Gallia GL, Lim M, Brem H, Quiones-Hinojosa A.
World Neurosurg. 2013 Mar-Apr;79(3-4):515-24. doi: 10.1016/j.wneu.2012.02.051. Epub 2012 Mar 30.
17.The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Lim M, Bower RS, Wang Y, Sims L, Bower MR, Camara-Quintana J, Li G, Cheshier S, Harsh GR 4th, Steinberg GK, Guccione S.
Neurosurg Rev. 2012 Jul;35(3):413-9; discussion 419. doi: 10.1007/s10143-012-0375-4. Epub 2012 Feb 28.
18.Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment.
Jackson C, Ruzevick J, Phallen J, Belcaid Z, Lim M.
Clin Dev Immunol. 2011;2011:732413. doi: 10.1155/2011/732413. Epub 2011 Dec 10. Review.
19.Stereotactic radiosurgery of cranial arteriovenous malformations and dural arteriovenous fistulas.
See AP, Raza S, Tamargo RJ, Lim M.
Neurosurg Clin N Am. 2012 Jan;23(1):133-46. doi: 10.1016/j.nec.2011.09.011. Review.
20.Effectiveness of repeat glycerol rhizotomy in treating recurrent trigeminal neuralgia.
Bender M, Pradilla G, Batra S, See A, Bhutiani N, James C, Carson BS, Lim M.
Neurosurgery. 2012 May;70(5):1125-33; discussion 1133-4. doi: 10.1227/NEU.0b013e31823f5eb6.
Research Interests
- Trigeminal Neuralgia
- Brain Metastases
- Spine Radiosurgery
- Brain Tumor Vaccines
More Info
Languages
- English
- Korean
Clinical Trials
- EGFRvIII, Vaccine
- Oncophage
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