Title(s):
Professor of Neurological Surgery
Professor of Oncology
Professor of Oncology
Appointment Phone:
410-550-3367
Primary Location:
Johns Hopkins Bayview Medical Center
Expertise:
Brain Cancer, Brain Stem Tumors, Brain Tumors, Endoscopy, Neurosurgery, Pituitary Tumors, Skull Base Surgery, Skull Base Tumors
Education and Experience
Training
- Harvard Medical School (Boston MA)/ (1999)
Residencies
- University of California San Francisco (San Francisco CA)/ Neurosurgery (2005)
Fellowships
- University of California San Francisco (San Francisco CA) / inclusive in residency (2005)
Certifications
- Neurological Surgery, American Board of Neurological Surgery (2010)
Locations
Johns Hopkins Bayview Medical Center
4940 Eastern Avenue
301 Mason Lord Drive Room 2100
Baltimore, MD 21224
Phone: 410-550-3367
Appointment Phone: 410-550-3367
Fax: 410-550-0748
Location Map
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Appointment Phone: 410-955-6406
Location Map
Johns Hopkins Outpatient Center
601 N. Caroline Street
Baltimore, MD 21287
Appointment Phone: 410-955-6406
Location Map
Department / Division
-
Neurosurgery - Neuro-Oncology
Neurosurgery - Brain Tumor
Neurosurgery - Neurological Surgery
Centers/Institutes
Centers / Institutes
- Brain Tumor Center
- Pituitary Center
- Sidney Kimmel Comprehensive Cancer Center
- Skull Base Tumor Center
Bio
Biography
At Johns Hopkins, Dr. Alfredo Quinones is a Professor of Neurosurgery and Oncology, Neuroscience and Cellular and Molecular Medicine. In addition to directing the Brain Tumor Surgery Program at Johns Hopkins Bayview Hospital, and the Pituitary Surgery Program at the Johns Hopkins Hospital, Dr. Quinones leads the Brain Tumor Stem Cell Laboratory.
Dr. Alfredo Quinones focuses on the surgical treatment of primary and metastatic brain tumors, with an emphasis on motor and speech mapping during surgery, as well as in the treatment of patients with pituitary and skull base tumors using transphenoidal endonasal and minimally invasive surgical approaches.
Dr. Alfredo Quinones focuses on the surgical treatment of primary and metastatic brain tumors, with an emphasis on motor and speech mapping during surgery, as well as in the treatment of patients with pituitary and skull base tumors using transphenoidal endonasal and minimally invasive surgical approaches.
Awards and Honors
2011:
Invited keynote speaker for Success for All Foundation Annual Convention
Martinez and Townsel Endowed Lecture at the Marine Biological Laboratory
MBL Friday Night Lecture at the Marine Biological Laboratory
Honorary Doctor of Humane Letters at Southern Vermont College
Commencement address at Southern Vermont Colleges 84th Commencement ceremony
Invited keynote speaker for Success for All Foundation Annual Convention
Martinez and Townsel Endowed Lecture at the Marine Biological Laboratory
MBL Friday Night Lecture at the Marine Biological Laboratory
Honorary Doctor of Humane Letters at Southern Vermont College
Commencement address at Southern Vermont Colleges 84th Commencement ceremony
Expertise
- Brain Cancer
- Brain Stem Tumors
- Brain Tumors
- Endoscopy
- Neurosurgery
- Pituitary Tumors
- Skull Base Surgery
- Skull Base Tumors
Professional Highlights
Dr. Alfredo Quinones-Hinojosa has been named one of the United States Brilliant 10 Scientists by Popular Science Magazine (2007) as well as one of the Top 100 Most Influential Hispanics in the U.S. by the Hispanic Business Journal (2007). He received the 2008 National Leadership in Science and Medicine Award by the Merage Foundation and the Woodrow Wilson International Center for Scholars in Washington, DC. Dr. Quinones was awarded the California Community College Distinguished Alumni Award in 2009 and participated as an invited scientist at the 2010 Nifty Fifty USA Science and Engineering Festival in 2010. In addition, he has been awarded many prestigious grants including awards from The Howard Hughes Medical Institute, Robert Wood Foundation, and Maryland Stem Cell Research Fund.
Research
Research and Publications
Dr. Quinones conducts numerous research efforts on elucidating the role of stem cells in the origin of brain tumors and the potential role stem cells can play in fighting brain cancer and regaining neurological function. In addition to leading the Brain Tumor Stem Cell Laboratory, he also heads the Neuro-Oncology Surgical Outcomes Research Laboratory where he is working to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors.
Chaichana, K.L.; Capilla-Gonzalez, V.; Gonzalez-Perez, O.; Pradilla, G.; Han, J.; Olivi, A.; Brem, H.; Garcia-Verdugo, J.M.; Quinones-Hinojosa, A. Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. Journal of neuroscience methods. 2007 Aug 30;164(2):261-270.
Attenello, F.J.; Mukherjee, D.; Datoo, G.; McGirt, M.J.; Bohan, E.; Weingart, J.D.; Olivi, A.; Quinones-Hinojosa, A.; Brem, H. Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience. Annals of surgical oncology. 2008 Oct;15(10):2887-2893.
McGirt, M.J.; Chaichana, K.L.; Attenello, F.J.; Weingart, J.D.; Than, K.; Burger, P.C.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. 2008 Oct;63(4):700-707; author reply 707-708.
Chaichana, K.L.; McGirt, M.J.; Niranjan, A.; Olivi, A.; Burger, P.C.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing low-grade gliomas in adults and a review of the literature. Neurological research. 2009 Nov;31(9):931-939.
Chaichana, K.L.; Parker, S.L.; Olivi, A.; Quinones-Hinojosa, A. Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article. Journal of neurosurgery. 2009 Aug;111(2):282-292.
Gathinji, M.; McGirt, M.J.; Attenello, F.J.; Chaichana, K.L.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A. Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surg Neurol. 2009 Mar;71(3):299-303, discussion 303.
McGirt, M.J.; Chaichana, K.L.; Gathinji, M.; Attenello, F.J.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A.R. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. Journal of neurosurgery. 2009 Jan;110(1):156-162.
McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.
Sun, P.; Xia, S.; Lal, B.; Eberhart, C.G.; Quinones-Hinojosa, A.; Maciaczyk, J.; Matsui, W.; Dimeco, F.; Piccirillo, S.M.; Vescovi, A.L.; Laterra, J. DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells. 2009 Jul;27(7):1473-1486.
Achanta, P.; Sedora Roman, N.I.; Quinones-Hinojosa, A. Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anti-cancer agents in medicinal chemistry. 2010;10(2):121-130.
Chaichana, K.; Parker, S.; Olivi, A.; Quinones-Hinojosa, A. A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme. Journal of neurosurgery. 2010;112(5):997-1004.
Chaichana, K.L.; Kosztowski, T.; Niranjan, A.; Olivi, A.; Weingart, J.D.; Laterra, J.; Brem, H.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. Journal of neurosurgery. 2010;113(2):286-292.
Chaichana, K.L.; McGirt, M.J.; Laterra, J.; Olivi, A.; Quinones-Hinojosa, A. Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas. Journal of neurosurgery. 2010;112(1):10-17.
Chaichana, K.L.; McGirt, M.J.; Woodworth, G.F.; Datoo, G.; Tamargo, R.J.; Weingart, J.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurological research. 2010;32(4):442-448.
Frazier, J.L.; Johnson, M.W.; Burger, P.C.; Weingart, J.D.; Quinones-Hinojosa, A. Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature. World neurosurgery. 2010;73(1):53-62; discussion e55.
Grossman, R.; Mukherjee, D.; Chang, D.C.; Purtell, M.; Lim, M.; Brem, H.; Quinones-Hinojosa, A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Annals of surgical oncology. 2010 (Journal Article).
Hales, R.K.; Shokek, O.; Burger, P.C.; Paynter, N.P.; Chaichana, K.L.; Quinones-Hinojosa, A.; Jallo, G.I.; Cohen, K.J.; Song, D.Y.; Carson, B.S.; Wharam, M.D. Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis. Journal of neuro-oncology. 2010;99(1):65-71.
Hughes, S.A.; Achanta, P.; Ho, A.L.; Duenas, V.J.; Quinones-Hinojosa, A. Biological horizons for targeting brain malignancy. Advances in Experimental Medicine and Biology. 2010;671(Journal Article):93-104.
Mukherjee, D.; Chang, D.C.; Quinones-Hinojosa, A. New methods to assess trends in neuro-oncological care. Journal of neuro-oncology. 2010;97(1):155-156.
Mukherjee, D.; Zaidi, H.A.; Kosztowski, T.; Chaichana, K.L.; Brem, H.; Chang, D.C.; Quinones-Hinojosa, A. Disparities in access to neuro-oncologic care in the United States. Archives of surgery (Chicago, Ill: 1960). 2010;145(3):247-253.
Ying, M.; Sang, Y.; Li, Y.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.; Vescovi, A.L.; Eberhart, C.G.; Xia, S.; Laterra, J. KLF9, A Differentiation-Associated Transcription Factor, Suppresses Notch1 Signaling and Inhibits Glioblastoma-Initiating Stem Cells. Stem cells. 2010;Epub 11/18/10(Journal Article).
Chaichana, K.L.; Capilla-Gonzalez, V.; Gonzalez-Perez, O.; Pradilla, G.; Han, J.; Olivi, A.; Brem, H.; Garcia-Verdugo, J.M.; Quinones-Hinojosa, A. Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. Journal of neuroscience methods. 2007 Aug 30;164(2):261-270.
Attenello, F.J.; Mukherjee, D.; Datoo, G.; McGirt, M.J.; Bohan, E.; Weingart, J.D.; Olivi, A.; Quinones-Hinojosa, A.; Brem, H. Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience. Annals of surgical oncology. 2008 Oct;15(10):2887-2893.
McGirt, M.J.; Chaichana, K.L.; Attenello, F.J.; Weingart, J.D.; Than, K.; Burger, P.C.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. 2008 Oct;63(4):700-707; author reply 707-708.
Chaichana, K.L.; McGirt, M.J.; Niranjan, A.; Olivi, A.; Burger, P.C.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing low-grade gliomas in adults and a review of the literature. Neurological research. 2009 Nov;31(9):931-939.
Chaichana, K.L.; Parker, S.L.; Olivi, A.; Quinones-Hinojosa, A. Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article. Journal of neurosurgery. 2009 Aug;111(2):282-292.
Gathinji, M.; McGirt, M.J.; Attenello, F.J.; Chaichana, K.L.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A. Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surg Neurol. 2009 Mar;71(3):299-303, discussion 303.
McGirt, M.J.; Chaichana, K.L.; Gathinji, M.; Attenello, F.J.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A.R. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. Journal of neurosurgery. 2009 Jan;110(1):156-162.
McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.
Sun, P.; Xia, S.; Lal, B.; Eberhart, C.G.; Quinones-Hinojosa, A.; Maciaczyk, J.; Matsui, W.; Dimeco, F.; Piccirillo, S.M.; Vescovi, A.L.; Laterra, J. DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells. 2009 Jul;27(7):1473-1486.
Achanta, P.; Sedora Roman, N.I.; Quinones-Hinojosa, A. Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anti-cancer agents in medicinal chemistry. 2010;10(2):121-130.
Chaichana, K.; Parker, S.; Olivi, A.; Quinones-Hinojosa, A. A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme. Journal of neurosurgery. 2010;112(5):997-1004.
Chaichana, K.L.; Kosztowski, T.; Niranjan, A.; Olivi, A.; Weingart, J.D.; Laterra, J.; Brem, H.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. Journal of neurosurgery. 2010;113(2):286-292.
Chaichana, K.L.; McGirt, M.J.; Laterra, J.; Olivi, A.; Quinones-Hinojosa, A. Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas. Journal of neurosurgery. 2010;112(1):10-17.
Chaichana, K.L.; McGirt, M.J.; Woodworth, G.F.; Datoo, G.; Tamargo, R.J.; Weingart, J.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurological research. 2010;32(4):442-448.
Frazier, J.L.; Johnson, M.W.; Burger, P.C.; Weingart, J.D.; Quinones-Hinojosa, A. Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature. World neurosurgery. 2010;73(1):53-62; discussion e55.
Grossman, R.; Mukherjee, D.; Chang, D.C.; Purtell, M.; Lim, M.; Brem, H.; Quinones-Hinojosa, A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Annals of surgical oncology. 2010 (Journal Article).
Hales, R.K.; Shokek, O.; Burger, P.C.; Paynter, N.P.; Chaichana, K.L.; Quinones-Hinojosa, A.; Jallo, G.I.; Cohen, K.J.; Song, D.Y.; Carson, B.S.; Wharam, M.D. Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis. Journal of neuro-oncology. 2010;99(1):65-71.
Hughes, S.A.; Achanta, P.; Ho, A.L.; Duenas, V.J.; Quinones-Hinojosa, A. Biological horizons for targeting brain malignancy. Advances in Experimental Medicine and Biology. 2010;671(Journal Article):93-104.
Mukherjee, D.; Chang, D.C.; Quinones-Hinojosa, A. New methods to assess trends in neuro-oncological care. Journal of neuro-oncology. 2010;97(1):155-156.
Mukherjee, D.; Zaidi, H.A.; Kosztowski, T.; Chaichana, K.L.; Brem, H.; Chang, D.C.; Quinones-Hinojosa, A. Disparities in access to neuro-oncologic care in the United States. Archives of surgery (Chicago, Ill: 1960). 2010;145(3):247-253.
Ying, M.; Sang, Y.; Li, Y.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.; Vescovi, A.L.; Eberhart, C.G.; Xia, S.; Laterra, J. KLF9, A Differentiation-Associated Transcription Factor, Suppresses Notch1 Signaling and Inhibits Glioblastoma-Initiating Stem Cells. Stem cells. 2010;Epub 11/18/10(Journal Article).
Research Interests
- Neuro-Oncology Surgical Outcomes Research: working to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors
- Stem cells in relation to the origin of brain tumors, and the potential role stem cells can play in fighting brain cancer and regaining neurological function
More Info
Languages
- English
- Spanish
Additional Resources
Johns Hopkins Comprehensive Brain Tumor Center
Johns Hopkins Pituitary Center
Johns Hopkins Skull Base Tumor Center
Johns Hopkins Brain Tumor Stem Cell Laboratory
Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory
Publications
Johns Hopkins Pituitary Center
Johns Hopkins Skull Base Tumor Center
Johns Hopkins Brain Tumor Stem Cell Laboratory
Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory
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