Title(s):
Assistant Professor of Pathology
Assistant Professor of Oncology
Assistant Professor of Oncology
Appointment Phone:
410-502-7214
Primary Location:
Johns Hopkins Bayview Medical Center
Expertise:
Anatomic and Clinical Pathology, Hematologic Pathology, Hematopathology, Leukemia, Lymphoma
Education and Experience
Training
- Baylor College of Medicine (Houston TX)/ (2004)
Residencies
- The Johns Hopkins Hospital (Baltimore MD)/ Pathology (2007)
Fellowships
- The Johns Hopkins Hospital (Baltimore MD)/ Pathology (2008)
Certifications
- Clinical Pathology, American Board of Pathology (2008)
- Hematology, American Board of Pathology-Pathology (2008)
Locations
Johns Hopkins Bayview Medical Center
4940 Eastern Avenue
Baltimore, MD 21224
Appointment Phone: 410-502-7214
Location Map
Johns Hopkins Outpatient Center
601 N. Caroline Street
Baltimore, MD 21287
Appointment Phone: 410-502-7214
Location Map
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Appointment Phone: 410-502-7214
Location Map
Department / Division
- Pathology
Centers/Institutes
Centers / Institutes
- Sidney Kimmel Comprehensive Cancer Center
Bio
Expertise
- Anatomic and Clinical Pathology
- Hematologic Pathology
- Hematopathology
- Leukemia
- Lymphoma
Research
Research and Publications
Research Summary
My laboratory studies roles of transposable elements and other mobile DNAs in human disease, with an emphasis on cancer development. There is compelling evidence that these poorly understood sequences can contribute to genomic instability and mRNA transcript alterations in the context of neoplasia, and we believe inherited insertions also may create predispositions to disease.
Projects in the lab include: (i.) The development of one-sided PCR based assays to map mobile DNAs in the human genome; (ii.) Finding evidence for somatic insertions of mobilized DNAs in cancers, and exploring potential clinical markers and mechanisms underlying this instability; (iii.) Describing common inherited transposon insertion polymorphisms in cancer patients and assessing whether these structural variations contribute to cancer susceptibility or tumor progression.
Journal Citations
Mobile interspersed repeats are major structural variants in the human genome. Huang CR, Schneider AM, Lu Y, Niranjan T, Shen P, Robinson MA, Steranka JP, Valle D, Civin CI, Wang T, Wheelan SJ, Ji H, Boeke JD, Burns KH. Cell. 2010 Jun 25;141(7):1171-82.
Roles of retrotransposons in benign and malignant hematologic disease. Schneider AM, Duffield AS, Symer DE, Burns KH. Cellscience. 2009 Oct 27;6(2):121-145
Great exaptations. Burns KH, Boeke JD. J Biol. 2008;7(2):5.
A descent into the nuage: the maelstrom of transposon control. O''Donnell KA, Burns KH, Boeke JD. Dev Cell. 2008 Aug;15(2):179-81.
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. Ma L, Buchold GM, Greenbaum MP, Roy A, Burns KH, Zhu H, Han DY, Harris RA, Coarfa C, Gunaratne PH, Yan W, Matzuk MM. PLoS Genet. 2009 Sep;5(9):e1000635.
Burns, F.J.; Samet, J.M.; Rossman, T.G.; Zhang, R.; Wu, F.; Uddin, A.N.; Shore, R.E. Radiation Carcinogenesis: Mechanisms of Induction. In: Rom, R.W., editor. 4th ed, Environmental and Occupational Medicine. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2007. p. 1262-1276.
Hanes, J.W.; Burns, K.E.; Hilmey, D.G.; Chatterjee, A.; Dorrestein, P.C.; Begley, T.P. Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. J Am Chem Soc. 2008 Mar 12;130(10):3043-3052.
Sandford, G.R.; Schumacher, U.; Ettinger, J.; Brune, W.; Hayward, G.S.; Burns, W.H.; Voigt, S. Deletion of the rat cytomegalovirus immediate early 1 gene results in a virus capable of establishing latency but with lower levels of acute virus replication and latency that compromise reactivation efficiency. J Gen Virol. 2009 Nov 18.
Wheless, L.; Ruczinski, I.; Alani, R.M.; Clipp, S.; Hoffman-Bolton, J.; Jorgensen, T.J.; Liegeois, N.J.; Strickland, P.T.; Alberg, A.J. The association between skin characteristics and skin cancer prevention behaviors. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2613-2619.
Burns, T.F.; Rudin, C.M. Lung cancer in 'never-smokers': beyond EGFR mutations and EGFR-TK inhibitors. Oncology (Williston Park). 2010 Jan;24(1):48-49.
Burns, W.R.; Zeiger, M.A. Differentiated thyroid cancer. Semin Oncol. 2010 Dec;37(6):557-566.
Huang, C.R.; Schneider, A.M.; Lu, Y.; Niranjan, T.; Shen, P.; Robinson, M.A.; Steranka, J.P.; Valle, D.; Civin, C.I.; Wang, T.; Wheelan, S.J.; Ji, H.; Boeke, J.D.; Burns, K.H. Mobile interspersed repeats are major structural variants in the human genome. Cell. 2010 Jun 25;141(7):1171-1182.
O'Donnell, K.A.; Burns, K.H. Mobilizing diversity: transposable element insertions in genetic variation and disease. Mob DNA. 2010;1(1):21.
My laboratory studies roles of transposable elements and other mobile DNAs in human disease, with an emphasis on cancer development. There is compelling evidence that these poorly understood sequences can contribute to genomic instability and mRNA transcript alterations in the context of neoplasia, and we believe inherited insertions also may create predispositions to disease.
Projects in the lab include: (i.) The development of one-sided PCR based assays to map mobile DNAs in the human genome; (ii.) Finding evidence for somatic insertions of mobilized DNAs in cancers, and exploring potential clinical markers and mechanisms underlying this instability; (iii.) Describing common inherited transposon insertion polymorphisms in cancer patients and assessing whether these structural variations contribute to cancer susceptibility or tumor progression.
Journal Citations
Mobile interspersed repeats are major structural variants in the human genome. Huang CR, Schneider AM, Lu Y, Niranjan T, Shen P, Robinson MA, Steranka JP, Valle D, Civin CI, Wang T, Wheelan SJ, Ji H, Boeke JD, Burns KH. Cell. 2010 Jun 25;141(7):1171-82.
Roles of retrotransposons in benign and malignant hematologic disease. Schneider AM, Duffield AS, Symer DE, Burns KH. Cellscience. 2009 Oct 27;6(2):121-145
Great exaptations. Burns KH, Boeke JD. J Biol. 2008;7(2):5.
A descent into the nuage: the maelstrom of transposon control. O''Donnell KA, Burns KH, Boeke JD. Dev Cell. 2008 Aug;15(2):179-81.
GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. Ma L, Buchold GM, Greenbaum MP, Roy A, Burns KH, Zhu H, Han DY, Harris RA, Coarfa C, Gunaratne PH, Yan W, Matzuk MM. PLoS Genet. 2009 Sep;5(9):e1000635.
Burns, F.J.; Samet, J.M.; Rossman, T.G.; Zhang, R.; Wu, F.; Uddin, A.N.; Shore, R.E. Radiation Carcinogenesis: Mechanisms of Induction. In: Rom, R.W., editor. 4th ed, Environmental and Occupational Medicine. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2007. p. 1262-1276.
Hanes, J.W.; Burns, K.E.; Hilmey, D.G.; Chatterjee, A.; Dorrestein, P.C.; Begley, T.P. Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. J Am Chem Soc. 2008 Mar 12;130(10):3043-3052.
Sandford, G.R.; Schumacher, U.; Ettinger, J.; Brune, W.; Hayward, G.S.; Burns, W.H.; Voigt, S. Deletion of the rat cytomegalovirus immediate early 1 gene results in a virus capable of establishing latency but with lower levels of acute virus replication and latency that compromise reactivation efficiency. J Gen Virol. 2009 Nov 18.
Wheless, L.; Ruczinski, I.; Alani, R.M.; Clipp, S.; Hoffman-Bolton, J.; Jorgensen, T.J.; Liegeois, N.J.; Strickland, P.T.; Alberg, A.J. The association between skin characteristics and skin cancer prevention behaviors. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2613-2619.
Burns, T.F.; Rudin, C.M. Lung cancer in 'never-smokers': beyond EGFR mutations and EGFR-TK inhibitors. Oncology (Williston Park). 2010 Jan;24(1):48-49.
Burns, W.R.; Zeiger, M.A. Differentiated thyroid cancer. Semin Oncol. 2010 Dec;37(6):557-566.
Huang, C.R.; Schneider, A.M.; Lu, Y.; Niranjan, T.; Shen, P.; Robinson, M.A.; Steranka, J.P.; Valle, D.; Civin, C.I.; Wang, T.; Wheelan, S.J.; Ji, H.; Boeke, J.D.; Burns, K.H. Mobile interspersed repeats are major structural variants in the human genome. Cell. 2010 Jun 25;141(7):1171-1182.
O'Donnell, K.A.; Burns, K.H. Mobilizing diversity: transposable element insertions in genetic variation and disease. Mob DNA. 2010;1(1):21.
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