Title(s):
Associate Professor of Neurology
Associate Professor of Anesthesiology and Critical Care Medicine
Assistant Professor of Medicine
Associate Professor of Neurological Surgery
Associate Professor of Anesthesiology and Critical Care Medicine
Assistant Professor of Medicine
Associate Professor of Neurological Surgery
Appointment Phone:
410-955-9441
Primary Location:
The Johns Hopkins Hospital
Expertise:
Critical Care Medicine, Neurological Critical Care, Stroke
Education and Experience
Training
- George Washington University School of Medicine (Washington DC)/ (1992)
Residencies
- Mayo Clinic Medical School College of Medicine (Rochester MN)/ Neurology (1999)
Fellowships
- National Institutes of Health (Bethesda MD)/ Critical Care Medicine (2002)
- The Johns Hopkins Hospital (Baltimore MD)/ Rotator/ Neurology (2002)
- NIH - HCPS - NINDS (Bethesda MD)/ Stroke (2001)
Certifications
- Neurology, American Board of Psychiatry & Neurology (2010)
- Vascular Neurology, American Board of Psychiatry & Neurology (2005)
Locations
The Johns Hopkins Hospital
600 N. Wolfe Street
Meyer Room 8-138
Baltimore, MD 21287
Phone: 410-955-2611
Appointment Phone: 410-955-9441
Fax: 410-614-7903
Location Map
Department / Division
-
Anesthesiology and Critical Care Medicine - Neurosciences Critical Care
-
Neurology - Cerebrovascular
Centers/Institutes
Bio
Biography
At Johns Hopkins, Dr. Paul Nyquist has two roles as an attending physician in the neurocritical care unit (NCCU) and as a member of the cerebrovascular team. His research goal is to bridge the gap between clinical trials and bench top innovations. He has embraced a research strategy characterized by two features. The first is an ongoing interest in any translational research projects that incorporate well founded biological models into patient care in brain injury. He has a theoretical focus which emphasizes the role of inflammation in cerebrovascular disease with particular attention to the effects of inflammation on endothelial activation. His goal is to develop acute interventions that will improve outcomes in patients with acute brain injury of any type.
Dr. Paul Nyquist received his medical degree and masters of public health degree from the George Washington University. After medical school, Dr. Nyquist completed his internal medicine internship at the National Naval Medical Center in Bethesda, Maryland. Upon completion, he was trained as a Navy Second Class Deep Sea Diver, radiation health specialist and an Undersea Medical Officer. Dr. Nyquist was part of the United States Naval world wide dive watch and rendered on call medical advice for diving and decompression related injuries for the United States Navy.
His clinical neurological training includes a neurology residency at the Mayo Clinic in Rochester, Minnesota as well as a senior staff clinical fellowship at the National Institutes of Health in the National Institutes of Neurological Diseases and Stroke in Bethesda, Maryland. He was a critical care medicine fellow in the ACGME accredited National Institutes of Health Critical Care Medicine program for 16 months. Dr. Nyquist then served as director of the stroke program at Inova Fairfax Hospital, assistant professor of Neurology at Virginia Commonwealth University Medical School, and clinical assistant professor of Psychiatry at Georgetown University Medical School. He completed his Neurocritical care fellowship training at Johns Hopkins and is now an Associate Professor of Neurology, Neurosurgery and Anesthesiology/Critical Care at the Johns Hopkins University School of Medicine.
Dr. Paul Nyquist received his medical degree and masters of public health degree from the George Washington University. After medical school, Dr. Nyquist completed his internal medicine internship at the National Naval Medical Center in Bethesda, Maryland. Upon completion, he was trained as a Navy Second Class Deep Sea Diver, radiation health specialist and an Undersea Medical Officer. Dr. Nyquist was part of the United States Naval world wide dive watch and rendered on call medical advice for diving and decompression related injuries for the United States Navy.
His clinical neurological training includes a neurology residency at the Mayo Clinic in Rochester, Minnesota as well as a senior staff clinical fellowship at the National Institutes of Health in the National Institutes of Neurological Diseases and Stroke in Bethesda, Maryland. He was a critical care medicine fellow in the ACGME accredited National Institutes of Health Critical Care Medicine program for 16 months. Dr. Nyquist then served as director of the stroke program at Inova Fairfax Hospital, assistant professor of Neurology at Virginia Commonwealth University Medical School, and clinical assistant professor of Psychiatry at Georgetown University Medical School. He completed his Neurocritical care fellowship training at Johns Hopkins and is now an Associate Professor of Neurology, Neurosurgery and Anesthesiology/Critical Care at the Johns Hopkins University School of Medicine.
Awards and Honors
United Nations Humans Rights Community Award 2003, United Nations Association of The National Capital Area: For the care of the victims of torture in the Washington D.C. Capital area.
General Loan Repayment Program, National Institute of Health 2000-2003.
American Neurological Association, travel fellow award: 2001.
American Epilepsy Society, Young Investigators Award: 1999.
Navy and Marine Corps Commendation Medal 1996.
GWU Medical School: Graduated with Distinction, AOA: 1992.
Navy Health Professional Scholarship 1989.
University of Michigan: Graduated distinction overall, with High-Honors from the Honors College: 1986.
Western Michigan University Phi Eta Sigma, Freshman Honors Society: 1981.
General Loan Repayment Program, National Institute of Health 2000-2003.
American Neurological Association, travel fellow award: 2001.
American Epilepsy Society, Young Investigators Award: 1999.
Navy and Marine Corps Commendation Medal 1996.
GWU Medical School: Graduated with Distinction, AOA: 1992.
Navy Health Professional Scholarship 1989.
University of Michigan: Graduated distinction overall, with High-Honors from the Honors College: 1986.
Western Michigan University Phi Eta Sigma, Freshman Honors Society: 1981.
Expertise
- Critical Care Medicine
- Neurological Critical Care
- Stroke
Professional Highlights
Presently; Assistant professor of Johns Hopkins University School of Medicine. Primary appointment in Neurology and Anesthesia Critical Care Medicine, and Neurosurgery.
Naval Medical Research Institute (NMRI); Bethesda, MD (1994-1996)Head of Health Monitoring, Project Officer/ Principal Investigator, Naval International Dive watch. (1994-1996). Credentials office, National Naval Medical Center, 8901 Wisconsin Ave., Bethesda, Maryland, 20889-5501, (301) 295-1157, (301) 295-4611.
Director of the Stroke Program, INOVA Fairfax Hospital (2002-2004) , Staff Neurologist INOVA Fairfax Hospital , Neurology Clerkship Director Virginia Commonwealth University Branch Campus Medical School at INOVA Fairfax Hospital.
Virginia Commonwealth University School of Medicine (January 2003-present): Assistant Professor
Georgetown University School of Medicine (April 2004-2006):
Clinical Assistant Professor, Clinical Tract
George Mason University (April 2003-2006)
Affiliate Professor
Krasnow Institute George Mason University (July 2003-2006):
Affiliate Professor
National Institutes of Health, Magnusson Clinical Center (2002-present) Special Volunteer
Naval Medical Research Institute (NMRI); Bethesda, MD (1994-1996)Head of Health Monitoring, Project Officer/ Principal Investigator, Naval International Dive watch. (1994-1996). Credentials office, National Naval Medical Center, 8901 Wisconsin Ave., Bethesda, Maryland, 20889-5501, (301) 295-1157, (301) 295-4611.
Director of the Stroke Program, INOVA Fairfax Hospital (2002-2004) , Staff Neurologist INOVA Fairfax Hospital , Neurology Clerkship Director Virginia Commonwealth University Branch Campus Medical School at INOVA Fairfax Hospital.
Virginia Commonwealth University School of Medicine (January 2003-present): Assistant Professor
Georgetown University School of Medicine (April 2004-2006):
Clinical Assistant Professor, Clinical Tract
George Mason University (April 2003-2006)
Affiliate Professor
Krasnow Institute George Mason University (July 2003-2006):
Affiliate Professor
National Institutes of Health, Magnusson Clinical Center (2002-present) Special Volunteer
Research
Research and Publications
Extramural Funding
NIH/NINDS RO-1, Funded, Principal Investigator 1R01NS062059-01A1, GRANT00431125, Occult Small Vessel Cerebrovascular Disease in High Risk Families.
Investigator / Inteventional Management of Stroke (IMS) III NIH Sponsored Clinical Trial
Principal Investigator/ Clinical Trial of rFVIIa (Novoseven) in Patients with
Intracerebral Hemorrhage at Johns Hopkins University, Sponsored by NOVONORDISK
Principal Investigator/ Desmotaplase in Acute Stroke at Johns Hopkins University (DIAS), Sponsored by Forest Pharmaceuticals
Investigator, CLEAR, Use of rt-PA for the Resolution of Clot in Intra-
ventricular Hemorrhage, Sponsored by FDA Orphan Drug Program
Investigator / CREST, Carotid Revascularization Endarterectomy vs. Stent Trial, NIH Sponsored Clinical Trial
Principal Investigator/ Siblings with Ischemic Stroke Study Stroke, INOVA Fairfax Hospital
Department of Defense Sponsored Research Projects
Principle Investigator, Project Officer-1993-1996: Complement Levels in Experimental Divers Before and After Dives with a High Predicted Risk of Decompression Sickness.
Project Officer, Principle Investigator -1994-1996: Desmopressin in Submersion Diueresis in Dives of Long Duration.
Project Officer-1995 - 1997: Human Decompression Trial with 1.3 ATA Oxygen in Helium.63713N.M0099.01A.1510.
Medical Monitor-1995 - 1997: Hyperbarcia Recognition and Thermal Status of Exercising Divers Exposed to Cold Water and Elevated PCO2. 63713N.M0099.01B.1428.
Publications:
Paul A. Nyquist MD, MPH , Cherie A. Winkler, PhD , Louise M. McKenzie, PhD , Lisa R. Yanek, MPH , Lewis C. Becker, MD , Diane M. Becker, ScD, MPH Single Nucleotide Polymorphisms in Monocyte Chemoattractant Protein-1 and its Receptor Act Synergistically to Increase the Risk of Carotid Atherosclerosis, Cerebrovascular Disease, accepted.
Paul A Nyquist, Wityck R., Lisa R. Yanek, David Yousem, Lewis C. Becker, Diane M. Becker, High Prevalence of Silent Small Vessel Cerebrovascular Disease and Co-occurrence with Occult Coronary Disease in Healthy Individuals from High Risk Families. Neuroepidemiology accepted
Nyquist P, Stevens RD, Mirski MA. Neurologic injury and mechanical ventilation.
Neurocrit Care. 2008;9(3):400-8. Epub 2008 Aug 12
Stevens RD, Nyquist PA.Types of brain dysfunction in critical illness. Neurol Clin. 2008 May;26(2):469-86, ix
Naval NS, Nyquist PA, Carhuapoma JR.Management of spontaneous intracerebral hemorrhage. Neurol Clin. 2008 May;26(2):373-84, vii.
Toung TJ, Nyquist P, Mirski MA. Effect of hypertonic saline concentration on cerebral and visceral organ water in an uninjured rodent model. Crit Care Med. 2007 Oct 23;
Nyquist P, LeDroux S, Geocadin R. Thrombolytics in intraventricular hemorrhage. Curr Neurol Neurosci Rep. 2007 Nov;7(6):522-8.
Nyquist P, Ball R, Sheridan MJ, Complement levels before and after dives with a high risk of DCS,Undersea Hyperbaric Medicine, UHM 2007, 34(3), 191.
Stevens RD, Nyquist PA. Coma, delirium, and cognitive dysfunction in critical illness.
Crit Care Clin. 2006 Oct;22(4):787-804;
Nyquist PA, Ball R, Sheridan MJ. Complement levels before and after dives with a high predicted risk of decompression sickness. Naval Medical Research Center, Silver Spring, MD. Technical report No. 2006-001; June 2006.
Nyquist P.A., Buttolph T, Dick C., "Detection of leukocyte activation in pigs with neurologic decompression sickness", Aviat Space Environ Med. 2004 Mar;75(3):211-4.
Lattimore SU, Chalela J, Davis L, Degraba T, Ezzeddine M, Haymore J, Nyquist P, Baird AE, Hallenbeck J, Warach S, Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience. Stroke. 2003 Jun;34(6): 2003 May 15
Worrall BB, Azhar S, Nyquist PA, Ackerman RH, Hamm TL, DeGraba TJ. Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis. Stroke. 2003 Mar;34(3):790-3
Nyquist PA, Cascino GD, McClelland RL, Annegers JF, Rodriguez M. Incidence of seizures in patients with multiple sclerosis: a population-based study. Mayo Clin. Proc. 2002 Sep;77(9):910-2.
Nyquist PA, Cascino GD, Rodriguez M. Seizures in patients with multiple sclerosis seen at Mayo Clinic, Rochester, Minn., 1990-1998. Mayo Clin. Proc. 2001 Oct;76(10):983-6.
Nyquist P.A., R.D. Brown, Jr., D.O. Wiebers, C.S. Crowson, and W.M. OFallon Circadian and seasonal occurrence of subarachnoid and intracerebral hemorrhage
Neurology. 2001 56: 190-193.
Nyquist P, Laws ER, Elliot E, Novel features of tumors that secrete both growth hormone and prolactin in acromegally, Neurosurgery. Vol. 35, No. 2, 179-185, 1995.
NIH/NINDS RO-1, Funded, Principal Investigator 1R01NS062059-01A1, GRANT00431125, Occult Small Vessel Cerebrovascular Disease in High Risk Families.
Investigator / Inteventional Management of Stroke (IMS) III NIH Sponsored Clinical Trial
Principal Investigator/ Clinical Trial of rFVIIa (Novoseven) in Patients with
Intracerebral Hemorrhage at Johns Hopkins University, Sponsored by NOVONORDISK
Principal Investigator/ Desmotaplase in Acute Stroke at Johns Hopkins University (DIAS), Sponsored by Forest Pharmaceuticals
Investigator, CLEAR, Use of rt-PA for the Resolution of Clot in Intra-
ventricular Hemorrhage, Sponsored by FDA Orphan Drug Program
Investigator / CREST, Carotid Revascularization Endarterectomy vs. Stent Trial, NIH Sponsored Clinical Trial
Principal Investigator/ Siblings with Ischemic Stroke Study Stroke, INOVA Fairfax Hospital
Department of Defense Sponsored Research Projects
Principle Investigator, Project Officer-1993-1996: Complement Levels in Experimental Divers Before and After Dives with a High Predicted Risk of Decompression Sickness.
Project Officer, Principle Investigator -1994-1996: Desmopressin in Submersion Diueresis in Dives of Long Duration.
Project Officer-1995 - 1997: Human Decompression Trial with 1.3 ATA Oxygen in Helium.63713N.M0099.01A.1510.
Medical Monitor-1995 - 1997: Hyperbarcia Recognition and Thermal Status of Exercising Divers Exposed to Cold Water and Elevated PCO2. 63713N.M0099.01B.1428.
Publications:
Paul A. Nyquist MD, MPH , Cherie A. Winkler, PhD , Louise M. McKenzie, PhD , Lisa R. Yanek, MPH , Lewis C. Becker, MD , Diane M. Becker, ScD, MPH Single Nucleotide Polymorphisms in Monocyte Chemoattractant Protein-1 and its Receptor Act Synergistically to Increase the Risk of Carotid Atherosclerosis, Cerebrovascular Disease, accepted.
Paul A Nyquist, Wityck R., Lisa R. Yanek, David Yousem, Lewis C. Becker, Diane M. Becker, High Prevalence of Silent Small Vessel Cerebrovascular Disease and Co-occurrence with Occult Coronary Disease in Healthy Individuals from High Risk Families. Neuroepidemiology accepted
Nyquist P, Stevens RD, Mirski MA. Neurologic injury and mechanical ventilation.
Neurocrit Care. 2008;9(3):400-8. Epub 2008 Aug 12
Stevens RD, Nyquist PA.Types of brain dysfunction in critical illness. Neurol Clin. 2008 May;26(2):469-86, ix
Naval NS, Nyquist PA, Carhuapoma JR.Management of spontaneous intracerebral hemorrhage. Neurol Clin. 2008 May;26(2):373-84, vii.
Toung TJ, Nyquist P, Mirski MA. Effect of hypertonic saline concentration on cerebral and visceral organ water in an uninjured rodent model. Crit Care Med. 2007 Oct 23;
Nyquist P, LeDroux S, Geocadin R. Thrombolytics in intraventricular hemorrhage. Curr Neurol Neurosci Rep. 2007 Nov;7(6):522-8.
Nyquist P, Ball R, Sheridan MJ, Complement levels before and after dives with a high risk of DCS,Undersea Hyperbaric Medicine, UHM 2007, 34(3), 191.
Stevens RD, Nyquist PA. Coma, delirium, and cognitive dysfunction in critical illness.
Crit Care Clin. 2006 Oct;22(4):787-804;
Nyquist PA, Ball R, Sheridan MJ. Complement levels before and after dives with a high predicted risk of decompression sickness. Naval Medical Research Center, Silver Spring, MD. Technical report No. 2006-001; June 2006.
Nyquist P.A., Buttolph T, Dick C., "Detection of leukocyte activation in pigs with neurologic decompression sickness", Aviat Space Environ Med. 2004 Mar;75(3):211-4.
Lattimore SU, Chalela J, Davis L, Degraba T, Ezzeddine M, Haymore J, Nyquist P, Baird AE, Hallenbeck J, Warach S, Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience. Stroke. 2003 Jun;34(6): 2003 May 15
Worrall BB, Azhar S, Nyquist PA, Ackerman RH, Hamm TL, DeGraba TJ. Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis. Stroke. 2003 Mar;34(3):790-3
Nyquist PA, Cascino GD, McClelland RL, Annegers JF, Rodriguez M. Incidence of seizures in patients with multiple sclerosis: a population-based study. Mayo Clin. Proc. 2002 Sep;77(9):910-2.
Nyquist PA, Cascino GD, Rodriguez M. Seizures in patients with multiple sclerosis seen at Mayo Clinic, Rochester, Minn., 1990-1998. Mayo Clin. Proc. 2001 Oct;76(10):983-6.
Nyquist P.A., R.D. Brown, Jr., D.O. Wiebers, C.S. Crowson, and W.M. OFallon Circadian and seasonal occurrence of subarachnoid and intracerebral hemorrhage
Neurology. 2001 56: 190-193.
Nyquist P, Laws ER, Elliot E, Novel features of tumors that secrete both growth hormone and prolactin in acromegally, Neurosurgery. Vol. 35, No. 2, 179-185, 1995.
Research Interests
- Intracranial Hemorrhage
- Stroke Genetics
- Subarachnoid Hemorrhage
- White Matter Disease
- Acute Brain Injury
More Info
Languages
- English
Memberships
Fellow of the American Heart Association (2007)
Member of the American Heart Association (1999)
American Academy of Neurology (1996)
Society of Critical Care Medicine (2002)
Neuro Critical Care Society (2003)
Stroke Council (2003)
Alpha Omega Alpha (1992)
The Johns Hopkins Medical Surgical Society (2005)
Member of the American Heart Association (1999)
American Academy of Neurology (1996)
Society of Critical Care Medicine (2002)
Neuro Critical Care Society (2003)
Stroke Council (2003)
Alpha Omega Alpha (1992)
The Johns Hopkins Medical Surgical Society (2005)
Clinical Trials
- Intracranial Hemorrhage
- Subarachnoid Hemorrhage
- Stroke
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