Title(s):
Associate Professor of Anesthesiology and Critical Care Medicine
Appointment Phone:
410-955-7519
Primary Location:
The Johns Hopkins Hospital
Expertise:
Critical Care Medicine
Education and Experience
Training
- Harbin Medical University (Harbin City )/ (1982)
Residencies
- University of Cincinnati Hospital - GME (Cincinnati OH)/ Internal Medicine/Anesthesiology (2001)
Fellowships
- Johns Hopkins University School of Medicine (Baltimore MD)/ Cardiac Anesthesia (2002)
Certifications
- Anesthesiology, American Board of Anesthesiology (2004)
Locations
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Phone: 410-955-7519
Appointment Phone: 410-955-7519
Fax: 410-955-0994
Location Map
Department / Division
-
Anesthesiology and Critical Care Medicine - Cardiac Anesthesia
Centers/Institutes
Bio
Awards and Honors
5/1987 - 5/1989: William H. Davis Scholarship for Medical Research, Graduate Studies, University of Calgary, Canada
9/1992 - 8/1994: International Research Fellowship, American Heart Association. USA
7/2002 - 6/2004: Clinician-Scientis Award, JHU School of Medicine.
9/1992 - 8/1994: International Research Fellowship, American Heart Association. USA
7/2002 - 6/2004: Clinician-Scientis Award, JHU School of Medicine.
Expertise
- Critical Care Medicine
Research
Research and Publications
A. Selected Peer-reviewed articles
1. Backx, P.H., Gao, W.D., Azan-Backx, M.D., Marban, E. Mechanism of force inhibition by 2,3-butanedione monoxiime in rat cardiac muscle: role of intracellular calcium and cross-bridge Kinetics. J Physiol. 476:487-500, 1994).
2. Gao, W.D., Backx, P.H., Azan-Backx, M.D., Marban, E. Myofilament Ca2+ sensitivity in intact versus skinned rat ventricular muscle. Circ Res. 74;408-415, 1994.
3. Backx, P.H., Gao, W.D., Azan-Backx, M.D., Marban, E. The relationship between contractile force and intracellular [Ca2+]i in intact rat cardiac trabeculae. J Gen Physiol. 105:1-19, 1995.
4. Gao, W.D., Atar, A., Backx, P.H., Marban, E. Relationship between intracellular calcium and contractile force in stunned myocardium: Direct evidence for decreases myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle. Circ Res. 76:1036-1048, 1995
5. Gao, W.D., Liu, Y., Mellgren, R., Marban, E. Intrinsic myofilaments alterations underlying the decreased contractility of stunned myocardium: A consequence of calcium-dependent proteolysis? Circ Res. 78:455-465, 1996.
7. Liu, Y., Gao, W.D., O''Rourke, B., Marban, E. Synergistic potentiation of ATP-sensitive potassium currents by protein kinase C and adenosine: Implications for ischemic preconditioning. Circ Res. 78:443-454, 1996.
8. Gao, W.D., Liu, Y., Marban, E. Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle: Implications for the mechanism of stunned myocardium. Circulation 94:2597-2604, 1996.
9. Gao, W.D., Atar, D., Liu, Y., Perez, N.G., Murphy, A.M., Marban, E. Role of troponin I proteolysis in the pathogenesis of myocardial stunning. Circ Res. 80:393-399, 1997.
10. Gao, W.D., Perez, N.G., Marban,E. Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol. 507:175-184, 1998.
11. Perez, N.G., Gao, W.D., Marban, E. Novel myofilament calcium-sensitizing property of xanthine oxidase inhibitors. Circ Res. 83:423-430, 1998.
12. Gao, W.D., Perez, N.P., Seidman, C., Seidman, J., Marban, E. Altered cardiac excitation-contraction coupling in cardiac muscle from mutant mice with familial hypertrophic cardiomyopathy. J Clin Invest. 103:661-666, 1999.
13. Stull, L.B., Leppo, M.K., Szweda, L., Gao, W.D., Marban, E. Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy. Circ Res. 95:1005-1011, 2004.
14.Gao, W.D., Dai, T., Nyhan, D. Increased cross-bridge cycling rate in stunned myocardium. Am J Physiol. 290:H886-H893, 2006.
15. Dai, T., Ramirez-Correa, G., Gao, W.D. Apelin increases contractility in failing cardiac muscle. Eur J Pharma. 553:222-228, 2006)
16. Bilchick, K., Duncan, J.G., Ravi, R., Takimoto, E., Champion, H.C., Gao, W.D., Stull, L.S., Kass, D.A., Murphy, A.M. Heart failure-associated alterations in troponin I phosphorylation impair left ventricular relaxation response to afterload, force-frequency response and systolic function. Am J Physiol. 292:H318-325, 2007.
17. Tocchetti, C.G., Wang, W., Froehlich, J.P., Valdivia, H.H., Pavlos, C.M., Aon, M., Wilson, G.M., di Benedetto, G., O Rourke, B., Miranda, K.M., Mancardi, D., Wink, D.A., Zaccolo, M., Toscano, J.P., Cheng, H., Gao, W.D., Kass, D.A., Paolocci, N. Nitroxyl (HNO) enhances sarcoplasmic reticulum Ca2+ cycling to increase cardiac contractility and relaxation Circ Res 100:96-104, 2007.
18. Dai, T., Tian, Y., Tocchetti, C.G., Katori, T.A., Kass, D.A., Paolocci, N., Gao, W.D. Nitroxyl anion (HNO/NO-) increases myofilament Ca2+ responsiveness in rat cardiac muscle. J Physiol. 580:951-960, 2007. (accompanying perspective by RJ Solaro: 580:697)
19. Jin, W., Z. Zhao, G.A. Ramirez-Correa, X. Zhong, W.D.Gao, G.W. Hart, A.M. Murphy. O-linked GlcNac Modification of Cardiac Myocardial Contractile Function. Circ Res. 103(12):1354-8, 2008
B. Selected book chapters and reviews
1. Marban, E., Gao, W.D. Stunned myocardium: a disease of the myofilaments? Basic Res Cardiol. 90:269-272, 1995.
2. Liu, Y., Gao, W.D., ORourke, B., Marban, E. Protein kinase C and adenosine synergistically activate ATP-sensitive potassium currents: Implications for ischemic preconditioning. In Adenosine, cardioprotection and clinical application. Eds: R.M. Mentzer, Jr, M. Kitakaze, J.M. Downey, M. Hori. Kluwer Academic Publishers, Boston, pp153-166,1997.
3. Gao, W.D., Marban, E. Myocardial stunning and preconditioning: clinical implications. In Perioperative Care of Cardiopulmonary Comprised Patients. Eds L Flesher and DS Prough, 13(2):pp172-180, 2001.
4. Gao, W.D., Murphy, A. Local Control in Thin Filament Activation of Cardiac Muscle. (Perspective) J Physiol. 580:358, 2007.
1. Backx, P.H., Gao, W.D., Azan-Backx, M.D., Marban, E. Mechanism of force inhibition by 2,3-butanedione monoxiime in rat cardiac muscle: role of intracellular calcium and cross-bridge Kinetics. J Physiol. 476:487-500, 1994).
2. Gao, W.D., Backx, P.H., Azan-Backx, M.D., Marban, E. Myofilament Ca2+ sensitivity in intact versus skinned rat ventricular muscle. Circ Res. 74;408-415, 1994.
3. Backx, P.H., Gao, W.D., Azan-Backx, M.D., Marban, E. The relationship between contractile force and intracellular [Ca2+]i in intact rat cardiac trabeculae. J Gen Physiol. 105:1-19, 1995.
4. Gao, W.D., Atar, A., Backx, P.H., Marban, E. Relationship between intracellular calcium and contractile force in stunned myocardium: Direct evidence for decreases myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle. Circ Res. 76:1036-1048, 1995
5. Gao, W.D., Liu, Y., Mellgren, R., Marban, E. Intrinsic myofilaments alterations underlying the decreased contractility of stunned myocardium: A consequence of calcium-dependent proteolysis? Circ Res. 78:455-465, 1996.
7. Liu, Y., Gao, W.D., O''Rourke, B., Marban, E. Synergistic potentiation of ATP-sensitive potassium currents by protein kinase C and adenosine: Implications for ischemic preconditioning. Circ Res. 78:443-454, 1996.
8. Gao, W.D., Liu, Y., Marban, E. Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle: Implications for the mechanism of stunned myocardium. Circulation 94:2597-2604, 1996.
9. Gao, W.D., Atar, D., Liu, Y., Perez, N.G., Murphy, A.M., Marban, E. Role of troponin I proteolysis in the pathogenesis of myocardial stunning. Circ Res. 80:393-399, 1997.
10. Gao, W.D., Perez, N.G., Marban,E. Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol. 507:175-184, 1998.
11. Perez, N.G., Gao, W.D., Marban, E. Novel myofilament calcium-sensitizing property of xanthine oxidase inhibitors. Circ Res. 83:423-430, 1998.
12. Gao, W.D., Perez, N.P., Seidman, C., Seidman, J., Marban, E. Altered cardiac excitation-contraction coupling in cardiac muscle from mutant mice with familial hypertrophic cardiomyopathy. J Clin Invest. 103:661-666, 1999.
13. Stull, L.B., Leppo, M.K., Szweda, L., Gao, W.D., Marban, E. Chronic treatment with allopurinol boosts survival and cardiac contractility in murine postischemic cardiomyopathy. Circ Res. 95:1005-1011, 2004.
14.Gao, W.D., Dai, T., Nyhan, D. Increased cross-bridge cycling rate in stunned myocardium. Am J Physiol. 290:H886-H893, 2006.
15. Dai, T., Ramirez-Correa, G., Gao, W.D. Apelin increases contractility in failing cardiac muscle. Eur J Pharma. 553:222-228, 2006)
16. Bilchick, K., Duncan, J.G., Ravi, R., Takimoto, E., Champion, H.C., Gao, W.D., Stull, L.S., Kass, D.A., Murphy, A.M. Heart failure-associated alterations in troponin I phosphorylation impair left ventricular relaxation response to afterload, force-frequency response and systolic function. Am J Physiol. 292:H318-325, 2007.
17. Tocchetti, C.G., Wang, W., Froehlich, J.P., Valdivia, H.H., Pavlos, C.M., Aon, M., Wilson, G.M., di Benedetto, G., O Rourke, B., Miranda, K.M., Mancardi, D., Wink, D.A., Zaccolo, M., Toscano, J.P., Cheng, H., Gao, W.D., Kass, D.A., Paolocci, N. Nitroxyl (HNO) enhances sarcoplasmic reticulum Ca2+ cycling to increase cardiac contractility and relaxation Circ Res 100:96-104, 2007.
18. Dai, T., Tian, Y., Tocchetti, C.G., Katori, T.A., Kass, D.A., Paolocci, N., Gao, W.D. Nitroxyl anion (HNO/NO-) increases myofilament Ca2+ responsiveness in rat cardiac muscle. J Physiol. 580:951-960, 2007. (accompanying perspective by RJ Solaro: 580:697)
19. Jin, W., Z. Zhao, G.A. Ramirez-Correa, X. Zhong, W.D.Gao, G.W. Hart, A.M. Murphy. O-linked GlcNac Modification of Cardiac Myocardial Contractile Function. Circ Res. 103(12):1354-8, 2008
B. Selected book chapters and reviews
1. Marban, E., Gao, W.D. Stunned myocardium: a disease of the myofilaments? Basic Res Cardiol. 90:269-272, 1995.
2. Liu, Y., Gao, W.D., ORourke, B., Marban, E. Protein kinase C and adenosine synergistically activate ATP-sensitive potassium currents: Implications for ischemic preconditioning. In Adenosine, cardioprotection and clinical application. Eds: R.M. Mentzer, Jr, M. Kitakaze, J.M. Downey, M. Hori. Kluwer Academic Publishers, Boston, pp153-166,1997.
3. Gao, W.D., Marban, E. Myocardial stunning and preconditioning: clinical implications. In Perioperative Care of Cardiopulmonary Comprised Patients. Eds L Flesher and DS Prough, 13(2):pp172-180, 2001.
4. Gao, W.D., Murphy, A. Local Control in Thin Filament Activation of Cardiac Muscle. (Perspective) J Physiol. 580:358, 2007.
Research Interests
- Oxidative Stress in Heart Failure; Excitation-contraction Coupling in Ischemia/reperfusion and Heart Failure; Cardiac Muscle Physiology
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Languages
- English
- Chinese
Memberships
American Society of Anesthesiology
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