Andrew P Lane, MD
Title(s): Professor of Otolaryngology-Head and Neck Surgery
Director, Johns Hopkins Sinus Center
Appointment Phone:
443-997-6467
Primary Location:
Johns Hopkins Outpatient Center
Expertise:
Endoscopic Frontal Sinus Surgery, Endoscopic Orbital Decompression for Graves' Disease, Endoscopic Repair of Nasal Cerebrospinal Fluid Leaks, Endoscopic Resection of Nasal Tumors, Endoscopic Tear Duct Surgery, Otolaryngology, Revision Endoscopic Sinus Surgery, Sinonasal Inverting Papillomas, Sinus Problems - Adult, Sinus Tumors
Education and Experience
Training
- University of Pennsylvania Health System School of Medicine (Philadelphia PA)/ (1994)
Residencies
- University of North Carolina Hospitals (Chapel Hill NC)/ Surgery/Otolaryngology (1999)
Fellowships
- University of Pennsylvania Health System School of Medicine (Philadelphia PA)/ Rhinology (2001)
Certifications
- Otolaryngology, American Board of Otolaryngology (2000)
Locations
Johns Hopkins Outpatient Center
601 N. Caroline Street
Baltimore, MD 21287
Phone: 410-955-7808
Appointment Phone: 443-997-6467
Location Map
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Phone: 410-955-7808
Appointment Phone: 443-997-6467
Fax: 410-614-8610
Location Map
Department / Division
-
Otolaryngology - Head and Neck Surgery - Rhinology
Centers/Institutes
Centers / Institutes
- Sinus Center
Bio
Biography
Dr. Andrew Lane performs the full range of endoscopic sinus procedures, including transnasal skull base and orbital surgeries. He is dedicated to providing cutting-edge care to his patients and developing new therapies for chronic rhinosinusitis through his clinical and basic science research.
Dr. Andrew Lane came to Johns Hopkins in 2001, after completing a one-year fellowship in advanced endoscopic sinus surgery techniques at the University of Pennsylvania, where he was trained by Drs David Kennedy and William Bolger. Dr. Lane directs the Johns Hokins Sinus Center and maintains a busy clinical practice, while also running an NIH-funded laboratory studying the causes of chronic sinusitis. An author of over 50 published articles and book chapters, he frequently presents his surgical and research results at national and international meetings. He has earned several prestigious awards for his research about nasal polyps and olfactory loss. Dr. Lane is often invited to speak at outside medical institutions and regularly conducts media interviews about nasal and sinus issues. He is an active member of the American Rhinologic Society, where he serves on the Board of Directors.
Dr. Andrew Lane came to Johns Hopkins in 2001, after completing a one-year fellowship in advanced endoscopic sinus surgery techniques at the University of Pennsylvania, where he was trained by Drs David Kennedy and William Bolger. Dr. Lane directs the Johns Hokins Sinus Center and maintains a busy clinical practice, while also running an NIH-funded laboratory studying the causes of chronic sinusitis. An author of over 50 published articles and book chapters, he frequently presents his surgical and research results at national and international meetings. He has earned several prestigious awards for his research about nasal polyps and olfactory loss. Dr. Lane is often invited to speak at outside medical institutions and regularly conducts media interviews about nasal and sinus issues. He is an active member of the American Rhinologic Society, where he serves on the Board of Directors.
Physician Title
Director, Johns Hopkins Sinus Center
Awards and Honors
Recipient of Earleen Elkins research award and GlaxoSmithKline research award from the American Academy of Otolaryngology Head and Neck Surgery Foundation
Passano Foundation Clinician Scientist Award
2005 and 2008 American Rhinologic Society Research Awards
2007 Maurice H. Cottle Award for Research in Rhinology
2009 Triological Society Edmund Prince Fowler Award
Passano Foundation Clinician Scientist Award
2005 and 2008 American Rhinologic Society Research Awards
2007 Maurice H. Cottle Award for Research in Rhinology
2009 Triological Society Edmund Prince Fowler Award
Expertise
- Endoscopic Frontal Sinus Surgery
- Endoscopic Orbital Decompression for Graves' Disease
- Endoscopic Repair of Nasal Cerebrospinal Fluid Leaks
- Endoscopic Resection of Nasal Tumors
- Endoscopic Tear Duct Surgery
- Otolaryngology
- Revision Endoscopic Sinus Surgery
- Sinonasal Inverting Papillomas
- Sinus Problems - Adult
- Sinus Tumors
Research
Research and Publications
Lane AP, Zweiman B, Lanza DC, Swift D, Doty R, Dhong H, Kennedy DW. Acoustic rhinometry in the study of the acute nasal allergic response. Ann. Otol. Rhinol. Laryngol. 1996; 105(10): 811-818.
Lane AP, Warren DW, Drake AF. Perceptual and physiologic effects of nasal congestion on nasal breathing. Am J Rhinology. 2000; 14(1):1-5.
Leinders-Zufall T, Lane AP, et al. Ultrasensitive and selective detection of putative pheromones by mammalian vomeronasal neurons. Nature. 2000; 405(6788):792796.
Lane AP, Pine HS, Pillsbury HC. Allergy testing and immunotherapy in an academic otolaryngology practice: a twenty-year review. Otolaryngol Head Neck Surg. Otolaryngol Head Neck Surg. 2001;124:9-15.
Munger SD, Lane AP, Zhong H, Leinders-Zufall T, Yau K,
Zufall F, Reed RR. Deletion of the OCNC2 channel gene reveals its central role in Ca2+/calmodulin-dependent odor adaptation. Science. 2001; 94:2172-2175.
Lane AP, Bolger WE. Endoscopic transmaxillary biopsy of pterygopalatine space masses. Am J Rhinology. 2002; 16(2):109-12.
Lane AP, Gomez G, Dankulich T, Wang H, Bolger WE, Rawson NE. The superior turbinate as a source of functional human olfactory receptor neurons. Laryngoscope. 2002; 112(7 Pt 1):1183-9.
Saatian B, Yu X, Lane AP, Casolaro V, Spannhake EW. Differentiation and cytokines modulate expression of genes for HLA and costimulatory molecules by human nasal epithelial cells. 2004. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L217-25
Lane AP, Saatian B, Yu X, Spannhake EW. mRNA for genes associated with antigen presentation are expressed by human middle meatal epithelial cells in culture. Laryngoscope. 2004; 114:1827-1832.
VanderMeer J, Sha Q, Lane AP, Schleimer RP. Innate immunity of the sinonasal cavity: expression of messenger RNA for complement cascade components and toll-like receptors. Arch Oto Head Neck Surg. 2004. 130: 1374-1380.
Lane AP, Zhao H, Reed R. Development of transgenic mouse models for the study of human olfactory dysfunction. Am J Rhinol. 2005; 19(3):229-235.
Lane AP, VanderMeer J, Sha Q, Plitt J, Bickel C, Myers A, Schleimer RP. Serum amyloid A, properdin, complement 3, and toll-like receptors are expressed locally in human sinonasal tissue. Am J Rhinol. 2006. Volume 20(1): 117-123.
Lane AP, Truong-Trang Q, Schleimer RP. Altered expression of genes associated with innate immunity and inflammation in recalcitrant rhinosinusitis with polyps. Am J Rhinol 2006;20(2):138-44.
Ramanathan M, Lee WK, Lane AP. Increased Expression of Acidic Mammalian Chitinase (AMCase) in Chronic Rhinosinusitis with Nasal Polyps. Am J Rhinol. 2006; 20(3):330-5.
Ramananthan M, Lane AP. Innate immunity of the sinonasal cavity and its role in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2007;136(3):348-56.
Ramanathan M, Lee WK, Dubin MG, Lin S, Spannhake EW, Lane AP. Sinonasal Epithelial Cell Expression of Toll-like Receptor 9 is Decreased in Chronic Rhinosinusitis with Polyps. Am J Rhinol. 2007; 21(1):110-6.
Schleimer RP, Lane AP, Kim J. Innate and acquired immunity and epithelial cell function in chronic rhinosinusitis. Clin Allergy Immunol. 2007; 20:51-78.
Ramanathan M, Lane AP. Chronic Rhinosinusitis with Nasal Polyps is Associated with Decreased Expression of Mucosal Interleukin 22 Receptor. Laryngoscope. 2007;117(10):1839-43.
Miller NR, Agrawal N, Sciubba JJ, Lane AP. Image-Guided Transnasal Endoscopic Resection of an Orbital Solitary Fibrous Tumor.Ophthal Plast Reconstr Surg. 2008; 24(1):65-7.
Lee WK, Ramanathan M, Spannhake EW, Lane AP. The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and HBD-2 by sinonasal epithelial cells. Am J Rhinol. 2007;21(6):658-63.
Ramanathan M Jr, Lee WK, Spannhake EW, Lane AP. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Am J Rhinol. 2008;22(2):115-21.
Miller NR, Agrawal N, Sciubba JJ, Lane AP. Image-guided transnasal endoscopic resection of an orbital solitary fibrous tumor. Ophthal Plast Reconstr Surg. 2008;24(1):65-7.
Ramanathan M Jr, Lee WK, Spannhake EW, Lane AP. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Am J Rhinol. 2008; 22(2):115-21.
Lalaker, A, Nkrumah N, Lee WK, Ramanathan M Jr, Lane AP. Chitin stimulates expression of acidic mammalian chitinase and eotaxin 3 by human sinonasal epithelial cells in vitro. Am J Rhinol Allergy. 2009;23(1):8-14.
Chu E, Miller NR, Lane AP. Selective endoscopic decompression of the orbital apex for dysthyroid optic neuropathy. Laryngoscope. 2009 May 5. [Epub ahead of print]
Lane AP, Warren DW, Drake AF. Perceptual and physiologic effects of nasal congestion on nasal breathing. Am J Rhinology. 2000; 14(1):1-5.
Leinders-Zufall T, Lane AP, et al. Ultrasensitive and selective detection of putative pheromones by mammalian vomeronasal neurons. Nature. 2000; 405(6788):792796.
Lane AP, Pine HS, Pillsbury HC. Allergy testing and immunotherapy in an academic otolaryngology practice: a twenty-year review. Otolaryngol Head Neck Surg. Otolaryngol Head Neck Surg. 2001;124:9-15.
Munger SD, Lane AP, Zhong H, Leinders-Zufall T, Yau K,
Zufall F, Reed RR. Deletion of the OCNC2 channel gene reveals its central role in Ca2+/calmodulin-dependent odor adaptation. Science. 2001; 94:2172-2175.
Lane AP, Bolger WE. Endoscopic transmaxillary biopsy of pterygopalatine space masses. Am J Rhinology. 2002; 16(2):109-12.
Lane AP, Gomez G, Dankulich T, Wang H, Bolger WE, Rawson NE. The superior turbinate as a source of functional human olfactory receptor neurons. Laryngoscope. 2002; 112(7 Pt 1):1183-9.
Saatian B, Yu X, Lane AP, Casolaro V, Spannhake EW. Differentiation and cytokines modulate expression of genes for HLA and costimulatory molecules by human nasal epithelial cells. 2004. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L217-25
Lane AP, Saatian B, Yu X, Spannhake EW. mRNA for genes associated with antigen presentation are expressed by human middle meatal epithelial cells in culture. Laryngoscope. 2004; 114:1827-1832.
VanderMeer J, Sha Q, Lane AP, Schleimer RP. Innate immunity of the sinonasal cavity: expression of messenger RNA for complement cascade components and toll-like receptors. Arch Oto Head Neck Surg. 2004. 130: 1374-1380.
Lane AP, Zhao H, Reed R. Development of transgenic mouse models for the study of human olfactory dysfunction. Am J Rhinol. 2005; 19(3):229-235.
Lane AP, VanderMeer J, Sha Q, Plitt J, Bickel C, Myers A, Schleimer RP. Serum amyloid A, properdin, complement 3, and toll-like receptors are expressed locally in human sinonasal tissue. Am J Rhinol. 2006. Volume 20(1): 117-123.
Lane AP, Truong-Trang Q, Schleimer RP. Altered expression of genes associated with innate immunity and inflammation in recalcitrant rhinosinusitis with polyps. Am J Rhinol 2006;20(2):138-44.
Ramanathan M, Lee WK, Lane AP. Increased Expression of Acidic Mammalian Chitinase (AMCase) in Chronic Rhinosinusitis with Nasal Polyps. Am J Rhinol. 2006; 20(3):330-5.
Ramananthan M, Lane AP. Innate immunity of the sinonasal cavity and its role in chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2007;136(3):348-56.
Ramanathan M, Lee WK, Dubin MG, Lin S, Spannhake EW, Lane AP. Sinonasal Epithelial Cell Expression of Toll-like Receptor 9 is Decreased in Chronic Rhinosinusitis with Polyps. Am J Rhinol. 2007; 21(1):110-6.
Schleimer RP, Lane AP, Kim J. Innate and acquired immunity and epithelial cell function in chronic rhinosinusitis. Clin Allergy Immunol. 2007; 20:51-78.
Ramanathan M, Lane AP. Chronic Rhinosinusitis with Nasal Polyps is Associated with Decreased Expression of Mucosal Interleukin 22 Receptor. Laryngoscope. 2007;117(10):1839-43.
Miller NR, Agrawal N, Sciubba JJ, Lane AP. Image-Guided Transnasal Endoscopic Resection of an Orbital Solitary Fibrous Tumor.Ophthal Plast Reconstr Surg. 2008; 24(1):65-7.
Lee WK, Ramanathan M, Spannhake EW, Lane AP. The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and HBD-2 by sinonasal epithelial cells. Am J Rhinol. 2007;21(6):658-63.
Ramanathan M Jr, Lee WK, Spannhake EW, Lane AP. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Am J Rhinol. 2008;22(2):115-21.
Miller NR, Agrawal N, Sciubba JJ, Lane AP. Image-guided transnasal endoscopic resection of an orbital solitary fibrous tumor. Ophthal Plast Reconstr Surg. 2008;24(1):65-7.
Ramanathan M Jr, Lee WK, Spannhake EW, Lane AP. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Am J Rhinol. 2008; 22(2):115-21.
Lalaker, A, Nkrumah N, Lee WK, Ramanathan M Jr, Lane AP. Chitin stimulates expression of acidic mammalian chitinase and eotaxin 3 by human sinonasal epithelial cells in vitro. Am J Rhinol Allergy. 2009;23(1):8-14.
Chu E, Miller NR, Lane AP. Selective endoscopic decompression of the orbital apex for dysthyroid optic neuropathy. Laryngoscope. 2009 May 5. [Epub ahead of print]
Research Interests
- Underlying mechanisms of chronic sinusitis
- Innate immunity of the nose and sinuses
- Inverted papilloma
- Endoscopic orbital surgery
- Nasal polyps
- olfactory loss due to chronic sinusitis
- Chronic sinusitis
More Info
Languages
- English
Memberships
American Rhinologic Society
American Academy of Otolaryngology - Head and Neck Surgery
American Academy of Otolaryngology - Head and Neck Surgery
Clinical Trials
- Chronic sinusitis with polyps
- Cerebrospinal fluid leaks
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