Title(s):
Assistant Professor of Neurology
Appointment Phone:
410-550-7095
Primary Location:
Johns Hopkins Bayview Medical Center
Expertise:
Neurology, Neuromuscular Disease, Neuromuscular Disorders, Peripheral Nerve Disorders
Education and Experience
Training
- University of Washington School of Medicine (Seattle WA)/ (1999)
Residencies
- The Johns Hopkins Hospital (Baltimore MD)/ Neurology (2003)
Fellowships
- The Johns Hopkins Hospital (Baltimore MD)/ Neurology (2004)
Certifications
- Clinical Neurophysiology, American Board of Psychiatry & Neurology (2007)
- Neurology, American Board of Psychiatry & Neurology (2005)
Locations
Johns Hopkins Bayview Medical Center
4940 Eastern Avenue
Lord Mason Drive, Building 301 Room Room 2100
Baltimore, MD 21224
Phone: 410-550-7095
Appointment Phone: 410-550-7095
Fax: 410-550-0539
Location Map
Department / Division
-
Neurology - Neuromuscular
Centers/Institutes
Centers / Institutes
- ALS Clinic
Bio
Biography
Dr. Thien Nguyen focuses on the diagnosis and treatment of neuromuscular and demyelinating diseases. The collective experience from multiple sclerosis, inflammatory demyelinating neuropathies, and heritable demyelinating diseases suggests that axonal degeneration accounts for a significant portion of the neurologic deficits in patients afflicted with these disorders.
Dr. Nguyens laboratory focuses on delineating the molecular mechanisms governing axonal degeneration in demyelinating and dysmyelinating disorders, so that neuroprotective strategies can be discovered. One promising neuroprotective agents is myelin-associated-glycoprotein (MAG), which Dr. Nguyens lab has shown to robustly prevent axonal degeneration in a variety of neural injury paradigms. Such promising neuroprotective agents identified in the laboratory can then be tested in future clinical trials in a ''bench-to-bedside'' manner to prevent axonal loss.
Dr. Thien Nguyen received his M.D. and Ph.D. from the University of Washington School of Medicine in Seattle. He then completed an internship in medicine at the University of Washington School of Medicine and residency in neurology at The Johns Hopkins Hospital in Baltimore. He went on to complete a fellowship in neuromuscular and neurophysiology at The Johns Hopkins Hospital in Baltimore.
Dr. Nguyens laboratory focuses on delineating the molecular mechanisms governing axonal degeneration in demyelinating and dysmyelinating disorders, so that neuroprotective strategies can be discovered. One promising neuroprotective agents is myelin-associated-glycoprotein (MAG), which Dr. Nguyens lab has shown to robustly prevent axonal degeneration in a variety of neural injury paradigms. Such promising neuroprotective agents identified in the laboratory can then be tested in future clinical trials in a ''bench-to-bedside'' manner to prevent axonal loss.
Dr. Thien Nguyen received his M.D. and Ph.D. from the University of Washington School of Medicine in Seattle. He then completed an internship in medicine at the University of Washington School of Medicine and residency in neurology at The Johns Hopkins Hospital in Baltimore. He went on to complete a fellowship in neuromuscular and neurophysiology at The Johns Hopkins Hospital in Baltimore.
Awards and Honors
National Multiple Sclerosis Society Grant, 2005-Present
Peripheral Nerve Society Fellowship Award, 2005
Nancy Davis Foundation Grant, 2005-Present
Speaker at Maryland Neurological Society, 2001
Student representative on medical school curriculum committee, 1995-1999
Molecular Biophysics Fellowship, 1992-1995
Peripheral Nerve Society Fellowship Award, 2005
Nancy Davis Foundation Grant, 2005-Present
Speaker at Maryland Neurological Society, 2001
Student representative on medical school curriculum committee, 1995-1999
Molecular Biophysics Fellowship, 1992-1995
Expertise
- Neurology
- Neuromuscular Disease
- Neuromuscular Disorders
- Peripheral Nerve Disorders
Research
Research and Publications
Publications:
Journals:
1. Nguyen, T., Chin, W.C., & Verdugo, P. (1998). Role of Ca2+/K+ ion exchange in intracellular storage and release of Ca2+. Nature 395, 908-912.
1. Nguyen, T., Chin, W.C., O''Brien, J. A., & Verdugo, P., & Berger, A. (2001). Intracellular pathways regulating ciliary beating of rat brain ependymal cells. J. Phys. (Lond.) 531 (1), 131-140 (cover article).
1. Chin, W.C., Quesada, I., Nguyen, T., & Verdugo, P. (2002). Oscillations of pH inside the
secretory granule control the gain of Ca2+ release for signal transduction in goblet cell exocytosis. Novartis Found Symp 248, 132-141.
1. Nguyen, T. (2002). Case 12: A 56-year old man with acute quadriparesis. Medscape.
Chapters in Books:
1. Nguyen T., Peter Kaplan. Imitators of Epilepsy. Clinical Presentation of Epilepsy, 1st ed. Ed. Le Quang Cuong. Nha Xuat Ban Y Hoc, 2005 (in Press Vietnamese)
2. Griffin, T, Hoke, A., Nguyen, T. Axonal Degeneration and Rescue. Textbook of Neural Repair and Rehabilitation, 2nd ed. Ed. Selzer, Clarke, Cohen, Duncan, and Gage. Cambridge University Press, 2005. (in Press)
Abstracts and Presentations:
1. Nguyen, T., Escobar, A., Vergara, J. & Verdugo, P. (1994). Ca2+ sub-compartmentalization in ciliated cells. NASA Annual Meeting.
1. Nguyen, T., & Verdugo, P. (1995). Detection of ciliary beat frequency and metachronal wavelength by two dimensional FFT analysis. Biophys. J. 68, A289.
2. Nguyen, T., & Verdugo, P. (1995). Sub-cellular compartmentalization of Ca2+ in respiratory ciliated cells. Amer. J. of Respir. and Critical Care Med. 151 (4), A652
3. Nguyen, T. (1996). Dynamics of cytosolic and compartmentalized Ca2+ during signal transduction. Ph.D. Thesis. University of Washington, Seattle, USA.
3. Nguyen, T., Arroyo, E. J., Scherer, S. S., & Griffin, J. W. (2004). β, β- Iminodipropionitrile-induced paranodal demyelination disrupts the molecular Organization of nodes. Annual Meeting of AAN S36, 005 (Platform presentation)
3. Nguyen, T., Sheikh, K, Garcia, M., Cleveland, D., Carteret, A., & Griffin, J. (2005) Neurofilament Phosphorylation is not Required for the Maintenance of Axonal Survival by MAG. PNS society meeting, S003 (Platform presentation).
Journals:
1. Nguyen, T., Chin, W.C., & Verdugo, P. (1998). Role of Ca2+/K+ ion exchange in intracellular storage and release of Ca2+. Nature 395, 908-912.
1. Nguyen, T., Chin, W.C., O''Brien, J. A., & Verdugo, P., & Berger, A. (2001). Intracellular pathways regulating ciliary beating of rat brain ependymal cells. J. Phys. (Lond.) 531 (1), 131-140 (cover article).
1. Chin, W.C., Quesada, I., Nguyen, T., & Verdugo, P. (2002). Oscillations of pH inside the
secretory granule control the gain of Ca2+ release for signal transduction in goblet cell exocytosis. Novartis Found Symp 248, 132-141.
1. Nguyen, T. (2002). Case 12: A 56-year old man with acute quadriparesis. Medscape.
Chapters in Books:
1. Nguyen T., Peter Kaplan. Imitators of Epilepsy. Clinical Presentation of Epilepsy, 1st ed. Ed. Le Quang Cuong. Nha Xuat Ban Y Hoc, 2005 (in Press Vietnamese)
2. Griffin, T, Hoke, A., Nguyen, T. Axonal Degeneration and Rescue. Textbook of Neural Repair and Rehabilitation, 2nd ed. Ed. Selzer, Clarke, Cohen, Duncan, and Gage. Cambridge University Press, 2005. (in Press)
Abstracts and Presentations:
1. Nguyen, T., Escobar, A., Vergara, J. & Verdugo, P. (1994). Ca2+ sub-compartmentalization in ciliated cells. NASA Annual Meeting.
1. Nguyen, T., & Verdugo, P. (1995). Detection of ciliary beat frequency and metachronal wavelength by two dimensional FFT analysis. Biophys. J. 68, A289.
2. Nguyen, T., & Verdugo, P. (1995). Sub-cellular compartmentalization of Ca2+ in respiratory ciliated cells. Amer. J. of Respir. and Critical Care Med. 151 (4), A652
3. Nguyen, T. (1996). Dynamics of cytosolic and compartmentalized Ca2+ during signal transduction. Ph.D. Thesis. University of Washington, Seattle, USA.
3. Nguyen, T., Arroyo, E. J., Scherer, S. S., & Griffin, J. W. (2004). β, β- Iminodipropionitrile-induced paranodal demyelination disrupts the molecular Organization of nodes. Annual Meeting of AAN S36, 005 (Platform presentation)
3. Nguyen, T., Sheikh, K, Garcia, M., Cleveland, D., Carteret, A., & Griffin, J. (2005) Neurofilament Phosphorylation is not Required for the Maintenance of Axonal Survival by MAG. PNS society meeting, S003 (Platform presentation).
More Info
Languages
- English
- Vietnamese
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