Associate Professor of Pediatrics
Education and Experience
- Duke University School of Medicine (Durham NC)/ (1986)
- University of Washington Medical Center (Seattle WA)/ Pediatrics (1989)
- University of Washington Medical Center (Seattle WA)/ Pediatric Heme/Onc (1992)
- Pediatric Hematology/Oncology, American Board of Pediatrics (2006)
- Pediatric Oncology
- Sidney Kimmel Comprehensive Cancer Center
In allogeneic BMT, nonablative preparative regimens can produce engraftment with less preparative-regimen-related toxicity, but at a price of more graft versus.host disease. In fact, GVHD is a major limitation of the success of BMT for all indications, but its morbidity and mortality are offset in patients with hematologic malignancies by an improved graft-versus-leukemia effect. Therefore, for patients with nonmalignant diseases, such as inherited hematologic and metabolic diseases that present during childhood, preventing GVHD is particularly important. Rodent models indicate that cyclophosphamide administered at a critical interval after mismatched BMT can specifically destroy alloreactive T cell clones, and Dr. Leo Luzniks trial in adult patients undergoing haploidentical BMT for hematologic malignancies supports a role for cyclophosphamide treatment after graft infusion to produce tolerance. Dr. Chen will test whether cyclophosphamide administered after graft infusion will allow long-term engraftment without GVHD in immune-competent patients with hemoglobinopathies receiving nonmyeloablative BMT.
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Chronic Myeloid Leukemia
- Pediatric Bone Marrow Transplant
- Pediatric Hematopoietic Cell Transplant
- Pediatric Oncology
Chen, A. R. (2005). Bone marrow transplantation in acute myeloid leukemia in children. In Surgery of Infants and Children: Scientific Principles and Practices 2nd edit. (Kline, R. M. & Kline, K. M., eds.). Lippincott-Raven, Philadelphia, PA.
Chen, A. R. (2006). Bone marrow transplant in acute myeloid leukemia in children. In Pediatric Bone Marrow Transplantation (Kline, R. M., ed.). Taylor and Francis, Philadelphia, PA.
Chen, J. G., S. Y. Kuang, P. A. Egner, J. H. Lu, Y. R. Zhu, J. B. Wang, B. C. Zhang, T. Y. Chen, A. Munoz, T. W. Kensler, and J. D. Groopman. 2007. Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry. Cancer Epidemiol Biomarkers Prev 16:1213-8.
Kim, G. R., Chen, A. R., Arceci, R. J., Mitchell, S. H., Kokoszka, K. M., Daniel, D. & Lehmann, C. U. (2006). Error reduction in pediatric chemotherapy: computerized order entry and failure modes and effects analysis. Arch Pediatr Adolesc Med 160, 495-8.
Luznik, L., O''Donnell, P.V., Symons, H.J., Chen, A.R., Leffell, M.S., Zahurak, M., Gooley, T.A., Piantadosi, S., Kaup, M., Ambinder, R.F., Huff, C.A., Matsui, W., Bolanos-Meade, J., Borrello, I., Powell, J.D., Harrington, E., Warnock, S., Flowers, M., Brodsky, R.A., Sandmaier, B.M., Storb, R.F., Jones, R.J., and Fuchs, E.J. (2008). HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 14, 641-650.
Milstone, A. M., Balakrishnan, S. L., Foster, C. B. & Chen, A. (2006). Failure of intravenous pentamidine prophylaxis to prevent pneumocystis pneumonia in a pediatric hematopoietic stem cell transplant (HSCT) patient. Pediatr Blood Cancer 47, 859-60.
Rubin, E., X. Wu, T. Zhu, J. C. Cheung, H. Chen, A. Lorincz, R. K. Pandita, G. G. Sharma, H. C. Ha, J. Gasson, L. A. Hanakahi, T. K. Pandita, and S. Sukumar. 2007. A role for the HOXB7 homeodomain protein in DNA repair. Cancer Res 67:1527-35.
Simpson, L. A., Burwell, E. A., Thompson, K. A., Shahnaz, S., Chen, A. R. & Loeb, D. M. (2006). The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy. Blood 107, 4695-702.
Williams, K.M., Higman, M.A., Chen, A.R., Schwartz, C.L., Wharam, M., Colombani, P., and Arceci, R.J. (2008). Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma. Pediatr Blood Cancer 50, 667-670.
Antin, J. H., Chen, A. R., Couriel, D. R., Ho, V. T., Nash, R. A., Weisdorf, D. 2004. Novel approaches to the therapy of steroid-resistant acute graft-versus-host disease. Biol. Blood Marrow Transplant 10:655-68.
Brodsky, R. A., Chen, A. R., Brodsky, I., Jones, R. J. 2004. High-dose cyclophosphamide as salvage therapy for severe aplastic anemia. Exp. Hematol. 32:435-40.
Higman, M., Vogelsang, G. B., Chen, A. 2004. Pentostatinpharmacology, immunology, and clinical effects in graft-versus-host disease. Expert Opin. Pharmacother. 5:2605-13.
Iannone, R., Ohene-Frempong, K., Fuchs, E. J., Casella, J. F., Chen, A. R. 2005. Bone marrow transplantation for sickle cell anemia: Progress and prospects. Pediatric Blood Cancer. 44:436-440.
- Pediatric Hematopoietic Cell Transplantation, Pediatric Bone Marrow Transplantation, Pediatric Oncology
- Pediatric Bone Marrow Transplantation, Pediatric Oncology