Title(s):
Associate Professor of Anesthesiology and Critical Care Medicine
Associate Professor of Pathology
Assistant Professor of Pediatrics
Associate Professor of Pathology
Assistant Professor of Pediatrics
Program Director, Pediatric Anesthesiology
Appointment Phone:
410-955-6412
Primary Location:
The Johns Hopkins Hospital
Expertise:
Critical Care Medicine
Education and Experience
Training
- University of Mississippi Medical Center (Jackson MS)/ (1987)
Residencies
- The Johns Hopkins Hospital (Baltimore MD)/ (1993)
Fellowships
- The Johns Hopkins Hospital (Baltimore MD)/ Anesthesiology and CCM (1994)
Certifications
- Pediatrics, American Board of Pediatrics (2007)
- Anesthesiology, American Board of Anesthesiology (2005)
Locations
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Phone: 410-955-6142
Appointment Phone: 410-955-6412
Fax: 410-614-2911
Location Map
Department / Division
-
Anesthesiology and Critical Care Medicine - Pediatric Anesthesia and Critical Care Medicine
Centers/Institutes
Centers / Institutes
- Autoimmune Disease Research
Bio
Physician Title
Program Director, Pediatric Anesthesiology
Awards and Honors
1998 Society of Pediatric Anesthesiology Young Investigator Award
2000-2002 Foundation for Anesthesia Education and Research Young Investigator Award
2000-2002 Foundation for Anesthesia Education and Research Young Investigator Award
Expertise
- Critical Care Medicine
Research
Research and Publications
1. Njoku D. Kliegman R. Atypical Extrapulmonary Presentations of Severe Respiratory Syncytial Virus Infections Requiring Intensive Care. Clinical Pediatrics 32:155-160, 1993.
2. Njoku DB, Laster MJ, Gong DH, Eger EI, Reed GF, Martin JL. Biotransformation of Halothane, Enflurane, Isoflurane and Desflurane to Trifluoroacetylated Liver Proteins: Association between Protein Acylation and Hepatic Injury. Anesthesia and Analgesia. 84:173-178, 1997.
3. Njoku DB, Shrestha S, Lon J, Soloway R, Duray PR, Tsokos M, Abu-Asab MS, Pohl LR, West AB. Subcellular Localization of Trifluoroacetylated Liver Proteins in Association with Hepatitis Following Isoflurane. Anesthesiology 96:757-761, 2002.
4. Njoku DB, Greenberg RS, Bourdi M, Dake B, Martin JL, Pohl LR. Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric Anesthesiologists. Anesthesia and Analgesia 94:243-249, 2002.
5. Fairweather D, Frisancho-Kiss S, Gatewood S, Njoku D, Steele R, Barrett M, Rose NR. Mast cells and innate cytokines are associated with susceptibility to autoimmune heart disease following Coxsackievirus B3 infection. Autoimmunity 37:131-145, 2004
6. Fairweather D, Frisancho-Kiss S, Yusung SA, Barrett MA, Davis SE, Gatewood SJ, Njoku DB and Rose NR. Interferon-γ protects against chronic viral myocarditis by reducing mast cell degranulation, figrosis, and the profibrotic cytokines transforming growth factor-β1, Interleukin-1β and interleukin-4 in the heart. Am J Pathol 165:1883-1894 2004.
7. Njoku DB, Talor MV, Fairweather D, Frisancho-Kiss S, Odumade OA and Rose NR. A Novel Model of Drug Hapten- Induced Hepatitis with Increased Mast Cells in the BALB/c Mouse. Exp Mol Pathol. 78:87- 100, 2005.
8. Njoku DB, Mellerson JL, Talor MV, Kerr, D R, Faraday NR, Outschoorn I and Rose NR. Role of CYP2E1 Immunoglobulin G4 Subclass Antibodies and Complement in the Pathogenesis of Idiosyncratic, Drug-Induced Hepatitis. Clin Vaccine Immunol. 2006 Feb;13(2):258-65.
9. Fairweather D, Frisancho-Kiss S, Njoku DB, Nyland JF. Kaya Z, Yusung SA, Davis SE, Frisancho A, Barrett M and Rose NR. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced mycarditis, dilated cardiomyopathy and heart failure by increasing macrophages, Il-2beta and immune complex deposition in the heart. J Immunol 176(6): 3516 - 24, 2006.
10. Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB, Cihakova D, Silbergeld EK, Rose NR and Fairweather D. Cutting Edge: Tim-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunology, 176(11): 6411 -15, 2006.
11. Anderson JS, Rose NR, Martin JL, Eger EI and Njoku DB. Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies. Anesthesia and Analgesia, 104 (6): 1452, 2007.
12. Nguyen C, Rose NR and Njoku DB. Trifluoroacetylated IgG4 antibodies in a child with Idiosyncratic acute liver failure following first exposure to halothane. Journal of Pediatric Gastroenterology and Nutrition 47(2):199 -202, 2008.
13. Njoku DB, Li Z, Mellerson JL , Sharma R, Talor MV, Barat N and Rose NR. IP-10 protects while MIP-2 promotes experimental drug hapten hepatitis. J Autoimmun. Feb;32(1):52-59, 2009.
14. Njoku DB, Li Z, Washington ND, Mellerson JL, Talor MV, Sharma R and Rose NR. In experimental drug induced liver injury, IL-4 suppresses regulatory responses to autoantigens but induces pro-inflammatory responses to drug haptens. European Journal of Immunology (in press)
Non-Experimental Articles
1. Martin JL and Njoku DB Understanding the Metabolism and Toxicity of Modern Inhaled Anesthetics. In: Anesthesia. 5th Edition. Ed: Miller RD. Churchill Livingstone, Philadelphia, PA , 2004.
2. Sharma R, Burek CL, Cihakova D, Njoku DB and Rose NR. Environmental Factors in Autoimmune Endocrinopathies. Editor: A P Weetman, Humana Press, Inc. in press, 2007.
3. Njoku D. Branchial Cleft Cyst. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Ed.: RS Litman. Pocketmedicine.com, New York, NY, 2007.
4. Kaufman S and Njoku D. Craniotomy for CNS Tumor Excision. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Ed.: RS Litman. Pocketmedicine.com, New York, NY, 2007.
5. Ajuba-Iwuji C and Njoku DB. Rashes. In PocketICUMedicine. Ed: M Wall. Pocketmedicine.com, New York, NY, 2008.
6. Ajuba-Iwuji C and Njoku DB. Traumatic Brain Injury in Hand book of Neuroanesthesia. Ed: J Kirsch and
A Brambrink. In press, 2009.
2. Njoku DB, Laster MJ, Gong DH, Eger EI, Reed GF, Martin JL. Biotransformation of Halothane, Enflurane, Isoflurane and Desflurane to Trifluoroacetylated Liver Proteins: Association between Protein Acylation and Hepatic Injury. Anesthesia and Analgesia. 84:173-178, 1997.
3. Njoku DB, Shrestha S, Lon J, Soloway R, Duray PR, Tsokos M, Abu-Asab MS, Pohl LR, West AB. Subcellular Localization of Trifluoroacetylated Liver Proteins in Association with Hepatitis Following Isoflurane. Anesthesiology 96:757-761, 2002.
4. Njoku DB, Greenberg RS, Bourdi M, Dake B, Martin JL, Pohl LR. Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric Anesthesiologists. Anesthesia and Analgesia 94:243-249, 2002.
5. Fairweather D, Frisancho-Kiss S, Gatewood S, Njoku D, Steele R, Barrett M, Rose NR. Mast cells and innate cytokines are associated with susceptibility to autoimmune heart disease following Coxsackievirus B3 infection. Autoimmunity 37:131-145, 2004
6. Fairweather D, Frisancho-Kiss S, Yusung SA, Barrett MA, Davis SE, Gatewood SJ, Njoku DB and Rose NR. Interferon-γ protects against chronic viral myocarditis by reducing mast cell degranulation, figrosis, and the profibrotic cytokines transforming growth factor-β1, Interleukin-1β and interleukin-4 in the heart. Am J Pathol 165:1883-1894 2004.
7. Njoku DB, Talor MV, Fairweather D, Frisancho-Kiss S, Odumade OA and Rose NR. A Novel Model of Drug Hapten- Induced Hepatitis with Increased Mast Cells in the BALB/c Mouse. Exp Mol Pathol. 78:87- 100, 2005.
8. Njoku DB, Mellerson JL, Talor MV, Kerr, D R, Faraday NR, Outschoorn I and Rose NR. Role of CYP2E1 Immunoglobulin G4 Subclass Antibodies and Complement in the Pathogenesis of Idiosyncratic, Drug-Induced Hepatitis. Clin Vaccine Immunol. 2006 Feb;13(2):258-65.
9. Fairweather D, Frisancho-Kiss S, Njoku DB, Nyland JF. Kaya Z, Yusung SA, Davis SE, Frisancho A, Barrett M and Rose NR. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced mycarditis, dilated cardiomyopathy and heart failure by increasing macrophages, Il-2beta and immune complex deposition in the heart. J Immunol 176(6): 3516 - 24, 2006.
10. Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB, Cihakova D, Silbergeld EK, Rose NR and Fairweather D. Cutting Edge: Tim-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunology, 176(11): 6411 -15, 2006.
11. Anderson JS, Rose NR, Martin JL, Eger EI and Njoku DB. Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies. Anesthesia and Analgesia, 104 (6): 1452, 2007.
12. Nguyen C, Rose NR and Njoku DB. Trifluoroacetylated IgG4 antibodies in a child with Idiosyncratic acute liver failure following first exposure to halothane. Journal of Pediatric Gastroenterology and Nutrition 47(2):199 -202, 2008.
13. Njoku DB, Li Z, Mellerson JL , Sharma R, Talor MV, Barat N and Rose NR. IP-10 protects while MIP-2 promotes experimental drug hapten hepatitis. J Autoimmun. Feb;32(1):52-59, 2009.
14. Njoku DB, Li Z, Washington ND, Mellerson JL, Talor MV, Sharma R and Rose NR. In experimental drug induced liver injury, IL-4 suppresses regulatory responses to autoantigens but induces pro-inflammatory responses to drug haptens. European Journal of Immunology (in press)
Non-Experimental Articles
1. Martin JL and Njoku DB Understanding the Metabolism and Toxicity of Modern Inhaled Anesthetics. In: Anesthesia. 5th Edition. Ed: Miller RD. Churchill Livingstone, Philadelphia, PA , 2004.
2. Sharma R, Burek CL, Cihakova D, Njoku DB and Rose NR. Environmental Factors in Autoimmune Endocrinopathies. Editor: A P Weetman, Humana Press, Inc. in press, 2007.
3. Njoku D. Branchial Cleft Cyst. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Ed.: RS Litman. Pocketmedicine.com, New York, NY, 2007.
4. Kaufman S and Njoku D. Craniotomy for CNS Tumor Excision. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Ed.: RS Litman. Pocketmedicine.com, New York, NY, 2007.
5. Ajuba-Iwuji C and Njoku DB. Rashes. In PocketICUMedicine. Ed: M Wall. Pocketmedicine.com, New York, NY, 2008.
6. Ajuba-Iwuji C and Njoku DB. Traumatic Brain Injury in Hand book of Neuroanesthesia. Ed: J Kirsch and
A Brambrink. In press, 2009.
Research Interests
- Mechanisms of immune-mediated, drug-induced liver injury
- Effects of occuptaional exposures to volatile anesthetics
More Info
Languages
- English
Memberships
American Academy of Pediatrics
American Society of Anesthesiology
Society for Education in Anesthesiology
The Society for Pediatric Anesthesia
American Board of Anesthesiology
Association of University Anesthesiologists
American Association of Immunologists
American Society of Anesthesiology
Society for Education in Anesthesiology
The Society for Pediatric Anesthesia
American Board of Anesthesiology
Association of University Anesthesiologists
American Association of Immunologists
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