Title(s):
Professor of Radiology and Radiological Science
Professor of Oncology
Professor of Radiation Oncology and Molecular Radiation Sciences
Professor of Oncology
Professor of Radiation Oncology and Molecular Radiation Sciences
Associate Director, Johns Hopkins In Vivo Cellular and Molecular Imaging Center
Director, Johns Hopkins Small Animal Imaging Resource
Director, Johns Hopkins Small Animal Imaging Resource
Appointment Phone:
410-550-2948
Primary Location:
Johns Hopkins Bayview Medical Center
Expertise:
General Radiology
Education and Experience
Training
- University of Illinois (Urbana IL)/ (1990)
Residencies
- Johns Hopkins University School of Medicine (Baltimore MD)/ Diagnostic Radiology/Nuclear Medicine (1995)
Fellowships
- Johns Hopkins University School of Medicine (Baltimore MD)/ Neuroradiology (1996)
Certifications
- Nuclear Medicine, American Board of Nuclear Medicine (2005)
- Diagnostic Radiology, American Board of Radiology (1995)
Locations
Johns Hopkins Bayview Medical Center
4940 Eastern Avenue
Baltimore, MD 21224
Appointment Phone: 410-550-2948
Location Map
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Appointment Phone: 410-955-6500
Location Map
Department / Division
- Radiology and Radiological Science
Centers/Institutes
Centers / Institutes
- In Vivo Cellular Molecular Imaging Center
- Sidney Kimmel Comprehensive Cancer Center
Bio
Biography
Dr. Pomper received his undergraduate, graduate and medical degrees from the University of Illinois at Urbana-Champaign (Ph.D., chemistry Katzenellenbogen). Postgraduate medical training was at Johns Hopkins and included internship (Osler Medical Service), residencies (diagnostic radiology and nuclear medicine) and fellowship (neuroradiology); board-certified in diagnostic radiology and nuclear medicine. Since 1996 he''s been on the Radiology faculty at Johns Hopkins. He''s currently the Director of the Johns Hopkins Small Animal Imaging Resource Program and Associate Director of the In Vivo Cellular and Molecular Imaging Center, both funded by the National Cancer Institute to support molecular imaging research. His interests are in the development of new radiopharmaceuticals, optical probes and techniques for molecular imaging of cancer and central nervous system disease. His research group consists of chemists, physicists, molecular biologists and clinicians working together toward clinical molecular imaging. He is the immediate past President of the Society of Nuclear Medicines Molecular Imaging Center of Excellence and Editor-in-Chief of the journal, Molecular Imaging.
Physician Title
Associate Director, Johns Hopkins In Vivo Cellular and Molecular Imaging Center
Director, Johns Hopkins Small Animal Imaging Resource
Director, Johns Hopkins Small Animal Imaging Resource
Expertise
- General Radiology
Research
Research and Publications
Research Summary
Molecular imaging research - from synthesis of new imaging agents to clinical translation. General areas include cancer, infection/inflammation and central nervous system disease. Examples of specific projects include imaging of prostate cancer through targeting the prostate-specific membrane antigen (PSMA), general cancer imaging through targeting of the CXCR4 chemokine receptor and use of the progression elevated gene 3 promoter (PEG-Prom). Molecular-genetic imaging. Targeted molecular radiotherapy of virus-associated tumors. Study of mechanisms underlying bioluminescence imaging signal. Chemical and radiochemical synthesis. Positron emission tomography of cancer, infection and neuropsychiatric disease.
Journal Citations
Banerjee SR, Pullambhatla M, Byun Y, Nimmagadda S, Green G, Fox JJ, Horti A, Mease RC, Pomper MG. (68)Ga-Labeled Inhibitors of Prostate-Specific Membrane Antigen (PSMA) for Imaging Prostate Cancer. J Med Chem. 2010 [Epub ahead of print]
Nimmagadda S, Pullambhatla M, Stone K, Green G, Bhujwalla ZM, Pomper MG.
Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography. Cancer Res. 2010;70:3935-44.
Wang H, Byun Y, Barinka C, Pullambhatla M, Bhang H-C, Fox JJ, Lubkowski J, Mease RC, Pomper, MG. Bioisosterism of urea-based GCPII inhibitors: synthesis and structure-activity relationships. Bioorg Med Chem Lett 2010;20:392-7.
Endres CJ, Pomper MG, James M, Uzuner O, Hammoud DA, Watkins C, Hilton J, Dannals RF, Kassiou M. Initial evaluation of [11C]DPA-713 in man. J Nucl Med, 2009, 50; 1276-82.
Zhang Y, Byun Y, Ren YR, Liu JO, Laterra J, Pomper MG. Identification of Inhibitors of ABCG2 by A Bioluminescence Imaging-based High-throughput Assay. Cancer Res, 2009, 69; 5867-75.
Fu D, Tanhehco Y, Chen J, Foss CA, Fox JJ, Chong J-M, Fukayama M, Sgouros G, Kowalski J, Pomper MG, Ambinder RF. Bortezomib-induced enzyme-targeted radiotherapy in herpesvirus-associated tumors. Nat Med 2008; 14: 1118-1122.
Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y, Fox JJ, Hilton J, Lupold S, Kozikowski AP, Pomper MG. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). J Med Chem 2008; 51:4504-4517.
Chandran SS, Banerjee SR, Mease RC, Pomper MG, Denmeade SR. Formulation, characterization and in vitro toxicity of docetaxel loaded PSMA-targeted nanoparticles. Cancer Biol Ther 2008; 7:974-982.
Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One 2007; 2:e1007.
Zhou J, Neale JH, Pomper MG, Kozikowski AP. NAAG Peptidase inhibitors and their potential for diagnosis and therapy. Nat Rev Drug Discovery, 2005; 4:1015-26. Pub
Bettegowda, C., Foss, C.A., Wang, Y., Fox, J., Zhou, S., Kinzler, K., Vogelstein, B., and Pomper, M.G. Imaging bacterial infection in live animals with radiolabeled FIAU, Proc. Natl. Acad. Sci. USA 102:1145-51150, 2005
Molecular imaging research - from synthesis of new imaging agents to clinical translation. General areas include cancer, infection/inflammation and central nervous system disease. Examples of specific projects include imaging of prostate cancer through targeting the prostate-specific membrane antigen (PSMA), general cancer imaging through targeting of the CXCR4 chemokine receptor and use of the progression elevated gene 3 promoter (PEG-Prom). Molecular-genetic imaging. Targeted molecular radiotherapy of virus-associated tumors. Study of mechanisms underlying bioluminescence imaging signal. Chemical and radiochemical synthesis. Positron emission tomography of cancer, infection and neuropsychiatric disease.
Journal Citations
Banerjee SR, Pullambhatla M, Byun Y, Nimmagadda S, Green G, Fox JJ, Horti A, Mease RC, Pomper MG. (68)Ga-Labeled Inhibitors of Prostate-Specific Membrane Antigen (PSMA) for Imaging Prostate Cancer. J Med Chem. 2010 [Epub ahead of print]
Nimmagadda S, Pullambhatla M, Stone K, Green G, Bhujwalla ZM, Pomper MG.
Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography. Cancer Res. 2010;70:3935-44.
Wang H, Byun Y, Barinka C, Pullambhatla M, Bhang H-C, Fox JJ, Lubkowski J, Mease RC, Pomper, MG. Bioisosterism of urea-based GCPII inhibitors: synthesis and structure-activity relationships. Bioorg Med Chem Lett 2010;20:392-7.
Endres CJ, Pomper MG, James M, Uzuner O, Hammoud DA, Watkins C, Hilton J, Dannals RF, Kassiou M. Initial evaluation of [11C]DPA-713 in man. J Nucl Med, 2009, 50; 1276-82.
Zhang Y, Byun Y, Ren YR, Liu JO, Laterra J, Pomper MG. Identification of Inhibitors of ABCG2 by A Bioluminescence Imaging-based High-throughput Assay. Cancer Res, 2009, 69; 5867-75.
Fu D, Tanhehco Y, Chen J, Foss CA, Fox JJ, Chong J-M, Fukayama M, Sgouros G, Kowalski J, Pomper MG, Ambinder RF. Bortezomib-induced enzyme-targeted radiotherapy in herpesvirus-associated tumors. Nat Med 2008; 14: 1118-1122.
Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y, Fox JJ, Hilton J, Lupold S, Kozikowski AP, Pomper MG. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). J Med Chem 2008; 51:4504-4517.
Chandran SS, Banerjee SR, Mease RC, Pomper MG, Denmeade SR. Formulation, characterization and in vitro toxicity of docetaxel loaded PSMA-targeted nanoparticles. Cancer Biol Ther 2008; 7:974-982.
Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One 2007; 2:e1007.
Zhou J, Neale JH, Pomper MG, Kozikowski AP. NAAG Peptidase inhibitors and their potential for diagnosis and therapy. Nat Rev Drug Discovery, 2005; 4:1015-26. Pub
Bettegowda, C., Foss, C.A., Wang, Y., Fox, J., Zhou, S., Kinzler, K., Vogelstein, B., and Pomper, M.G. Imaging bacterial infection in live animals with radiolabeled FIAU, Proc. Natl. Acad. Sci. USA 102:1145-51150, 2005
Research Interests
- Development of new radiotracers for PET and SPECT for cancer detection
- In Vivo and Molecular Imaging
- Radiopharmacology
- Oncology
More Info
Languages
- English
- French
Clinical Trials
- AIDS
- Dementia
- MS
- HIV
- PSMA
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