Title(s):
Professor of Psychiatry and Behavioral Sciences
Professor of Neurology
Professor of Neurology
Director, Johns Hopkins Schizophrenia Program
Director, Laboratory of Genetic Neurobiology
Director, Laboratory of Genetic Neurobiology
Appointment Phone:
410-955-0424
Primary Location:
The Johns Hopkins Hospital
Expertise:
Biological Psychiatry, Bipolar Disorder, Depression, Huntington's Disease, Huntington's Disease-Like 2, Mood Disorders, Psychiatry, Schizoaffective Disorder, Schizophrenia, Spinocerebellar Ataxia Type 12
Education and Experience
Training
- Johns Hopkins University School of Medicine (Baltimore MD)/ (1986)
Residencies
- Johns Hopkins School of Medicine (Baltimore MD)/ Psychiatry (1990)
Fellowships
- National Institutes of Health - Credentialing Services Section (Bethesda MD) / General Medical Studies (1992)
Certifications
- General, American Board of Psychiatry & Neurology-Psychiatry (1991)
Locations
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Phone: 410-614-4262
Appointment Phone: 410-955-0424
Location Map
Department / Division
-
Psychiatry and Behavioral Sciences - Division of Neurobiology
Centers/Institutes
Centers / Institutes
- Huntington's Disease Center
- Schizophrenia Program
Bio
Physician Title
Director, Johns Hopkins Schizophrenia Program
Director, Laboratory of Genetic Neurobiology
Director, Laboratory of Genetic Neurobiology
Awards and Honors
Canadian Found. for Innovation (reviewer 2007; Committee Chair, 2008), NARSAD Distinguished Investigator Award (2007), National Ataxia Found. Advisory Board, 2009-, reviewer (2006-2009), NARSAD Independent Investigator Award (2003), Lieberman Award of the Hereditary Disease Foundation (2002), CMM Admissions Committee (2002), Guest Editor of the International Rev Psychiatry (2001), Ad Hoc reviewer NIH BDCN3 (2000), Pathology Credentials Committee (2001), NARSAD Independent Investigator Award (1999), Comitato Promotore Telethon grant reviewer (Italy) (1998), FONDS FCAR reviewer (Canada) (1996), NARSAD Young Investigator Award (1995), Johns Hopkins Clinician Scientist Award (1994), NIMH K21 Scientist Development Award (1995), Pharmacology Research Associate Program fellowship (1990-1992), Rock Sleyster Memorial Scholarship (1986), Deans award for research (1984), Dennison Research Scholarship (1983), American Heart Assoc Research Scholarship (1983), Cannon Memorial Prize (1982), Senior Book Award (1982).
Expertise
- Biological Psychiatry
- Bipolar Disorder
- Depression
- Huntington's Disease
- Huntington's Disease-Like 2
- Mood Disorders
- Psychiatry
- Schizoaffective Disorder
- Schizophrenia
- Spinocerebellar Ataxia Type 12
Research
Research and Publications
Selected Publications:
Holmes SE, O''Hearn E, McInnis MG, Kwak NG, Gorelick-Feldman DA, Kleiderlein JK, Callahan C, Sherr M, Sharp AH, Sumner AJ, Ashworth RG, Ananth U, Seltzer W, Vieria-Saecker AM, Epplen JT, Reiss O, Ross CA, Margolis RL. Expansion of a novel CAG trinucleotide repeat in the 5'' region of PPP2R2B is associated with SCA12, Nature Genetics, 23 (1999): 391-392.
Margolis RL, OHearn E, Rosenblatt A, Willour V, Holmes SE, Franz ML, Callahan C, Hwang HS, Troncoso JC, Ross CA. A disorder similar to Huntingtons disease is associated with a novel CAG repeat expansion. Annals of Neurology, 50 (2001):373-380.
Holmes SE, OHearn E, Callahan C, Hwang HS, Rosenblatt A, Ingersoll-Ashworth RG, Fleisher A, Stevanin G, Brice A, Potter NT, Ross CA, Margolis RL. A CTG trinucleotide repeat expansion in Junctophilin 3 is associated with Huntington''s Disease-Like 2 (HDL2). Nature Genetics, 29 (2001): 377-378.
Margolis RL, Holmes SE, Rosenblatt A, Gourley L, OHearn E, Ross CA, Seltzer WK, Walker RH, Ashizawa T, Rasmussen A, Hayden M, Almqvist EW, Harris J, Fahn S, Macdonald ME, Mysore J, Shimohata T, Tsuji S, Potter N, Nakaso K, Adachi Y, Nakashima K, Bird T, Krause A, Greenstein P. Huntingtons disease-like 2 (HDL2) in North America and Japan. Annals of Neurology, 56(2004):670-674
Sachs NA, Sawa A, Holmes SE, Ross CA, DeLisi LE, Margolis RL. A frameshift mutation in Disrupted in Schizophrenia 1 segregates with schizophrenia and schizoaffective disorder in an American family. Molecular Psychiatry 10(2005) 758-64
Rudnicki DD, Holmes SE, Lin M, Thorton CA, Ross CA, Margolis RL. Huntingtons disease-like 2 is associated with CUG repeat containing RNA foci. Annals of Neurology, 61 (2007):272-82.
Rudnicki DD, Pletnikova O, Vansattel JP, Ross CA, Margolis RL. A comparison of Huntingtons disease and Huntingtons disease-like 2 neuropathology. Journal of Neuropathology and Experimental Neurology, 67(2008):366-
Bruce HA, Sachs NA, Rudnicki DD, Lin SG, Willour VL, Cowell JK, Conroy J, McQuaid D, Rossi M, Gaile DP, Nowak NJ, Holmes SE, Sklar P, Ross CA, DeLisi LE, Margolis RL. Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations. Psychiatric Genetics, in press.
Ross CA, Margolis RL, Reading SAJ, Pletnikov M, Coyle JT. Neurobiology of Schizophrenia, Neuron, 52 (2006):139-53
Margolis, RL. The choice of antipsychotics in schizophrenia. Nature Neurology Reveiws, in press.
Ross CA, Margolis RL. DISC1 and GSK3beta: New Pathways and Novel Therapeutic Targets for Schizophrenia and Bipolar Disorder, Nature News and Views, in press
Holmes SE, O''Hearn E, McInnis MG, Kwak NG, Gorelick-Feldman DA, Kleiderlein JK, Callahan C, Sherr M, Sharp AH, Sumner AJ, Ashworth RG, Ananth U, Seltzer W, Vieria-Saecker AM, Epplen JT, Reiss O, Ross CA, Margolis RL. Expansion of a novel CAG trinucleotide repeat in the 5'' region of PPP2R2B is associated with SCA12, Nature Genetics, 23 (1999): 391-392.
Margolis RL, OHearn E, Rosenblatt A, Willour V, Holmes SE, Franz ML, Callahan C, Hwang HS, Troncoso JC, Ross CA. A disorder similar to Huntingtons disease is associated with a novel CAG repeat expansion. Annals of Neurology, 50 (2001):373-380.
Holmes SE, OHearn E, Callahan C, Hwang HS, Rosenblatt A, Ingersoll-Ashworth RG, Fleisher A, Stevanin G, Brice A, Potter NT, Ross CA, Margolis RL. A CTG trinucleotide repeat expansion in Junctophilin 3 is associated with Huntington''s Disease-Like 2 (HDL2). Nature Genetics, 29 (2001): 377-378.
Margolis RL, Holmes SE, Rosenblatt A, Gourley L, OHearn E, Ross CA, Seltzer WK, Walker RH, Ashizawa T, Rasmussen A, Hayden M, Almqvist EW, Harris J, Fahn S, Macdonald ME, Mysore J, Shimohata T, Tsuji S, Potter N, Nakaso K, Adachi Y, Nakashima K, Bird T, Krause A, Greenstein P. Huntingtons disease-like 2 (HDL2) in North America and Japan. Annals of Neurology, 56(2004):670-674
Sachs NA, Sawa A, Holmes SE, Ross CA, DeLisi LE, Margolis RL. A frameshift mutation in Disrupted in Schizophrenia 1 segregates with schizophrenia and schizoaffective disorder in an American family. Molecular Psychiatry 10(2005) 758-64
Rudnicki DD, Holmes SE, Lin M, Thorton CA, Ross CA, Margolis RL. Huntingtons disease-like 2 is associated with CUG repeat containing RNA foci. Annals of Neurology, 61 (2007):272-82.
Rudnicki DD, Pletnikova O, Vansattel JP, Ross CA, Margolis RL. A comparison of Huntingtons disease and Huntingtons disease-like 2 neuropathology. Journal of Neuropathology and Experimental Neurology, 67(2008):366-
Bruce HA, Sachs NA, Rudnicki DD, Lin SG, Willour VL, Cowell JK, Conroy J, McQuaid D, Rossi M, Gaile DP, Nowak NJ, Holmes SE, Sklar P, Ross CA, DeLisi LE, Margolis RL. Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations. Psychiatric Genetics, in press.
Ross CA, Margolis RL, Reading SAJ, Pletnikov M, Coyle JT. Neurobiology of Schizophrenia, Neuron, 52 (2006):139-53
Margolis, RL. The choice of antipsychotics in schizophrenia. Nature Neurology Reveiws, in press.
Ross CA, Margolis RL. DISC1 and GSK3beta: New Pathways and Novel Therapeutic Targets for Schizophrenia and Bipolar Disorder, Nature News and Views, in press
Research Interests
- RNA toxicity
- Huntington''s disease: pathogenesis, clinical trials
- schizophrenia: genetics, pathogenesis, neuroimaging
- spinocerebellar ataxia type 12
- Huntington''s disease-like 2
More Info
Languages
- English
Memberships
American Psychiatric Association, International Society for Psychiatric Genetics, Maryland Psychiatric Society, Amercian Society for Human Genetics, Society for Neuroscience,
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