Title(s):
Associate Professor of Medicine
Associate Professor of Oncology
Associate Professor of Oncology
Appointment Phone:
410-955-6132
Primary Location:
The Johns Hopkins Hospital
Expertise:
Anemias, Blood Diseases in Young Adults, Bone Marrow Failure, Hematology, Hemoglobinopathies, Hemophilia, Iron Deficiency, Red Cell Disorders, Sickle Cell Disease, Thalassemias, Thrombocytopenias
Education and Experience
Training
- Medical College of Wisconsin (Milwaukee WI)/ (1986)
Residencies
- The Johns Hopkins Hospital (Baltimore MD)/ Pediatrics (1989)
Fellowships
- The Johns Hopkins Hospital (Baltimore MD)/ Pediatrics (1992)
Certifications
- Pediatric Hematology/Oncology, American Board of Pediatrics (2011)
Locations
The Johns Hopkins Hospital
600 N. Wolfe Street
Hospital Main Entrance - Sheikh Zayed Tower
Baltimore, MD 21287
Appointment Phone: 410-955-6132
Location Map
Department / Division
- Pediatrics
- Medicine
Centers/Institutes
Bio
Expertise
- Anemias
- Blood Diseases in Young Adults
- Bone Marrow Failure
- Hematology
- Hemoglobinopathies
- Hemophilia
- Iron Deficiency
- Red Cell Disorders
- Sickle Cell Disease
- Thalassemias
- Thrombocytopenias
Research
Research and Publications
Savage, W.J.; DeRusso, P.A.; Resar, L.M.; Chen, A.R.; Higman, M.A.; Loeb, D.M.; Jones, R.J.; Brodsky, R.A. Treatment of hepatitis-associated aplastic anemia with high-dose cyclophosphamide. Pediatr Blood Cancer. 2007 Dec;49(7):947-951.
Tesfaye, A.; Di Cello, F.; Hillion, J.; Ronnett, B.M.; Elbahloul, O.; Ashfaq, R.; Dhara, S.; Prochownik, E.; Tworkoski, K.; Reeves, R.; Roden, R.; Ellenson, L.H.; Huso, D.L.; Resar, L.M. The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. Cancer Res. 2007 May 1;67(9):3998-4004.
Di Cello, F.; Hillion, J.; Hristov, A.; Wood, L.J.; Mukherjee, M.; Schuldenfrei, A.; Kowalski, J.; Bhattacharya, R.; Ashfaq, R.; Resar, L.M. HMGA2 participates in transformation in human lung cancer. Mol Cancer Res. 2008 May;6(5):743-750.
Di Cello, F.; Hillion, J.; Kowalski, J.; Ronnett, B.M.; Aderinto, A.; Huso, D.L.; Resar, L.M. Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts. Mol Cancer Ther. 2008 Jul;7(7):2090-2095.
Hillion, J.; Dhara, S.; Sumter, T.F.; Mukherjee, M.; Di Cello, F.; Belton, A.; Turkson, J.; Jaganathan, S.; Cheng, L.; Ye, Z.; Jove, R.; Aplan, P.; Lin, Y.W.; Wertzler, K.; Reeves, R.; Elbahlouh, O.; Kowalski, J.; Bhattacharya, R.; Resar, L.M. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies Cancer Res. 2008 Dec 15;68(24):10121-10127.
Hines, P.; Dover, G.J.; Resar, L.M. Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia. Pediatr Blood Cancer. 2008 Feb;50(2):357-359.
Hillion, J.; Wood, L.J.; Mukherjee, M.; Bhattacharya, R.; Di Cello, F.; Kowalski, J.; Elbahloul, O.; Segal, J.; Poirier, J.; Rudin, C.M.; Dhara, S.; Belton, A.; Joseph, B.; Zucker, S.; Resar, L.M. Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer. Mol Cancer Res. 2009 Nov;7(11):1803-1812.
Hristov, A.C.; Cope, L.; Reyes, M.D.; Singh, M.; Iacobuzio-Donahue, C.; Maitra, A.; Resar, L.M. HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. Mod Pathol. 2009 Jan;22(1):43-49.
Hristov, A.C.; Cope, L.; Di Cello, F.; Reyes, M.D.; Singh, M.; Hillion, J.A.; Belton, A.; Joseph, B.; Schuldenfrei, A.; Iacobuzio-Donahue, C.A.; Maitra, A.; Resar, L.M. HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma. Mod Pathol. 2010 Jan;23(1):98-104.
Mazaheri, P.; Nadkarni, G.; Lowe, E.; Hines, P.; Vuica, M.; Griffin, M.; Resar, L.M. Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia. Pediatr Blood Cancer. 2010 Dec 1;55(6):1187-1190.
Resar, L.M. The high mobility group A1 gene: transforming inflammatory signals into cancer? Cancer Res. 2010 Jan 15;70(2):436-439.
Karp, J.E.; Smith, B.D.; Resar, L.S.; Greer, J.M.; Blackford, A.; Zhao, M.; Moton-Nelson, D.; Alino, K.; Levis, M.J.; Gore, S.D.; Joseph, B.; Carraway, H.; McDevitt, M.A.; Bagain, L.; Mackey, K.; Briel, J.; Doyle, L.A.; Wright, J.J.; Rudek, M.A. Phase I and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias. Blood. 2011 Jan 14;Epub 1/18/11.
Tesfaye, A.; Di Cello, F.; Hillion, J.; Ronnett, B.M.; Elbahloul, O.; Ashfaq, R.; Dhara, S.; Prochownik, E.; Tworkoski, K.; Reeves, R.; Roden, R.; Ellenson, L.H.; Huso, D.L.; Resar, L.M. The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. Cancer Res. 2007 May 1;67(9):3998-4004.
Di Cello, F.; Hillion, J.; Hristov, A.; Wood, L.J.; Mukherjee, M.; Schuldenfrei, A.; Kowalski, J.; Bhattacharya, R.; Ashfaq, R.; Resar, L.M. HMGA2 participates in transformation in human lung cancer. Mol Cancer Res. 2008 May;6(5):743-750.
Di Cello, F.; Hillion, J.; Kowalski, J.; Ronnett, B.M.; Aderinto, A.; Huso, D.L.; Resar, L.M. Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts. Mol Cancer Ther. 2008 Jul;7(7):2090-2095.
Hillion, J.; Dhara, S.; Sumter, T.F.; Mukherjee, M.; Di Cello, F.; Belton, A.; Turkson, J.; Jaganathan, S.; Cheng, L.; Ye, Z.; Jove, R.; Aplan, P.; Lin, Y.W.; Wertzler, K.; Reeves, R.; Elbahlouh, O.; Kowalski, J.; Bhattacharya, R.; Resar, L.M. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies Cancer Res. 2008 Dec 15;68(24):10121-10127.
Hines, P.; Dover, G.J.; Resar, L.M. Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia. Pediatr Blood Cancer. 2008 Feb;50(2):357-359.
Hillion, J.; Wood, L.J.; Mukherjee, M.; Bhattacharya, R.; Di Cello, F.; Kowalski, J.; Elbahloul, O.; Segal, J.; Poirier, J.; Rudin, C.M.; Dhara, S.; Belton, A.; Joseph, B.; Zucker, S.; Resar, L.M. Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer. Mol Cancer Res. 2009 Nov;7(11):1803-1812.
Hristov, A.C.; Cope, L.; Reyes, M.D.; Singh, M.; Iacobuzio-Donahue, C.; Maitra, A.; Resar, L.M. HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. Mod Pathol. 2009 Jan;22(1):43-49.
Hristov, A.C.; Cope, L.; Di Cello, F.; Reyes, M.D.; Singh, M.; Hillion, J.A.; Belton, A.; Joseph, B.; Schuldenfrei, A.; Iacobuzio-Donahue, C.A.; Maitra, A.; Resar, L.M. HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma. Mod Pathol. 2010 Jan;23(1):98-104.
Mazaheri, P.; Nadkarni, G.; Lowe, E.; Hines, P.; Vuica, M.; Griffin, M.; Resar, L.M. Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia. Pediatr Blood Cancer. 2010 Dec 1;55(6):1187-1190.
Resar, L.M. The high mobility group A1 gene: transforming inflammatory signals into cancer? Cancer Res. 2010 Jan 15;70(2):436-439.
Karp, J.E.; Smith, B.D.; Resar, L.S.; Greer, J.M.; Blackford, A.; Zhao, M.; Moton-Nelson, D.; Alino, K.; Levis, M.J.; Gore, S.D.; Joseph, B.; Carraway, H.; McDevitt, M.A.; Bagain, L.; Mackey, K.; Briel, J.; Doyle, L.A.; Wright, J.J.; Rudek, M.A. Phase I and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias. Blood. 2011 Jan 14;Epub 1/18/11.
Research Interests
- Basic research focus is hematologic malignancy and molecular mechanisms that lead to cancer. Clinical research interests include sickle cell anemia.
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Languages
- English
- French
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