Title(s):
Professor of Neurological Surgery
Professor of Oncology
Professor of Oncology
Director, Department of Neurosurgery
Harvey Cushing Professor of Neurosurgery
Neurosurgeon-in-Chief, The Johns Hopkins Hospital
Director, Hunterian Neurosurgical Research Laboratory
Harvey Cushing Professor of Neurosurgery
Neurosurgeon-in-Chief, The Johns Hopkins Hospital
Director, Hunterian Neurosurgical Research Laboratory
Appointment Phone:
410-955-2248
Primary Location:
The Johns Hopkins Hospital
Expertise:
Acoustic Neuromas, Brain Cancer, Brain Tumors, Gliomas, Meningiomas, Metastatic Brain Tumors, Neurosurgery, Pituitary Tumors, Skull Base Tumors
Education and Experience
Training
- Harvard Medical School (Boston MA)/ (1978)
Residencies
- Neurological Institute of New York (New York NY)/ Neurosurgery (1984)
Fellowships
- The Johns Hopkins Hospital (Baltimore MD)/ Neurosurgery and Ophthalmology (1980)
Certifications
- Neurological Surgery, American Board of Neurological Surgery (1986)
Locations
The Johns Hopkins Hospital
600 N. Wolfe Street
Sheikh Zayed Tower Room 6115A
Baltimore, MD 21287
Phone: 410-955-2249
Appointment Phone: 410-955-2248
Fax: 410-955-8263
Location Map
Department / Division
-
Neurosurgery - Neuro-Oncology
Neurosurgery - Brain Tumor
Neurosurgery - Neurological Surgery
Centers/Institutes
Centers / Institutes
- Acoustic Neuroma Center
- Brain Tumor Center
- Glioma Center
- Meningioma Center
- Metastatic Brain Tumor Center
- Pituitary Center
- Sidney Kimmel Comprehensive Cancer Center
Bio
Biography
Dr. Henry Brem focuses his clinical practice on the surgical treatment of pituitary tumors, meningiomas, gliomas, acoustic neuromas, skull base tumors and other solid brain tumors. He has developed new clinical treatments for brain tumors, including the delivery of chemotherapy directly to the brain through the Gliadel wafer, anti-angiogenesis therapies, computer navigation systems used during surgery and brain tumor vaccines.
Dr. Henry Brem graduated from Harvard Medical School with honors and trained in neurosurgery at Columbia University. He did a fellowship in neurosurgery and ophthalmology at Johns Hopkins and then joined the faculty in 1984. He rapidly rose to the rank of full professor and helped build one of the leading Brain Tumor Centers in the United States. He also directs the Hunterian Research Laboratory, which has introduced new therapies for brain tumors. In 2000, he was appointed the Harvey Cushing Professor, Neurosurgeon-in-Chief and Chairman of the Department of Neurosurgery.
Dr. Henry Brem graduated from Harvard Medical School with honors and trained in neurosurgery at Columbia University. He did a fellowship in neurosurgery and ophthalmology at Johns Hopkins and then joined the faculty in 1984. He rapidly rose to the rank of full professor and helped build one of the leading Brain Tumor Centers in the United States. He also directs the Hunterian Research Laboratory, which has introduced new therapies for brain tumors. In 2000, he was appointed the Harvey Cushing Professor, Neurosurgeon-in-Chief and Chairman of the Department of Neurosurgery.
Physician Title
Director, Department of Neurosurgery
Harvey Cushing Professor of Neurosurgery
Neurosurgeon-in-Chief, The Johns Hopkins Hospital
Director, Hunterian Neurosurgical Research Laboratory
Harvey Cushing Professor of Neurosurgery
Neurosurgeon-in-Chief, The Johns Hopkins Hospital
Director, Hunterian Neurosurgical Research Laboratory
Expertise
- Acoustic Neuromas
- Brain Cancer
- Brain Tumors
- Gliomas
- Meningiomas
- Metastatic Brain Tumors
- Neurosurgery
- Pituitary Tumors
- Skull Base Tumors
Research
Research and Publications
Chaichana KL, Pendleton C, Jackson C, Martinez-Gutierrez J, Diaz-Stransky A, Aguayo J, Olivi A, Weingart J, Gallia GL, Lim M, Brem H, Quiones-Hinojosa A: Deep vein thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors. Neurol Res. 2012 Dec 13. [Epub ahead of print] PMID:23336127.
Rege A, Seifert AC, Schlattman D, Ouyang Y, Li KW, Basaldella L, Brem H, Tyler BM, Thakor NV. Longitudinal IN VIVO Monitoring of rodent GLIOMA MODELS through thinned skull using Laser Speckle Contrast Imaging. J Biomed Opt. 2012 Dec 1;17(12):126017..PMID: 23235836.
Vellimana AK, Recinos VR, Hwang L, Fowers KD, Li KW, Zhang Y, Okonma S, Eberhart CG, Brem H, Tyler BM. Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model. 2012; 147(11):1017-24. PMID:23165616. . J Neurooncol. 2012 Dec 7. [Epub ahead of print]. PMID:23224713
Momin EN, Adams H, Shinohara RT, Frangakis C, Brem H, Quiones-Hinojosa A. Post-Operative 2012: Oct 19 [Epub ahead of print]. PMID:23082884 Mortality After Surgery for Brain Tumors Differs by Insurance Status in the United States. Arch Surg
Chaichana KL, Zadnik P, Weingart JD, Olivi A, Gallia GL, Blakeley J, Lim M, Brem H, Quiones-Hinojosa A. Multiple resections for patients with glioblastoma: prolonging survival. J Neurosurg.
Grossman R, Tyler B, Brem H, Eberhart CG, Wand S, Fu DX, Wen Z, Zhou J. Growth properties of SF 188/V+ human glioma in rats observed by magnetic resonance imaging. J Neurooncol. 2012; 110(3):315-23. PMID:23011120.
Kong S, Senqupta S, Tyler BM, Ma Q, Doucette S, Zhou J, Sahin A, Carter B, Brem H, Junghans RP, Sampath P. Supression of Human Glioma Xenografts with 2nd Generation IL13R-Specific Chimeric Antigen receptor-Modified T Cells. Clin Cancer Res. 2012;18(21):5949-5960.
Grossman R, Rudek MA, Brastianos H, Zadnik P, Brem H, Tyler B, Blakeley JO. The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas. Cancer Chemother Pharmacol. 2012; 70(1):129-39. PMID: 22644796.
Henry Brem, M.D. 14
Link TW, Woodworth GF, Chaichana KL, Grossman SA, Mayer RS, Brem H, Weingart JD, Quinones-Hinojosa A. Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma. J Clin Neurosci. 2012;19(7):966-1000. PMID:22595358.
Masi BC, Tyler BM, Bow H, Wicks RT, Xue Y, Brem H, Langer R, Cima MJ. Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. Biomaterials. 2012;33(23):5768-75. PMID:22591609.
Chaichana KL, Pendleton C, Zaidi H, Olivi A, Weingart JD, Gallia GL, Lim M, Brem H, Quinones-Hinojosa A. Seizure Control for Patients Undergoing Meningioma Surgery. World Neurosurg. 2012 Mar 30. [Epub ahead of print]PMID:22469524
Tyler BM, Hdeib A, Caplan J, Legnani FG, Fowers KD, Brem H, Jallo G, Pradilla G. Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel. J Neurosurg Spine . 2012;16(1):93-101 PMID:22208429.
Pendleton C, Olivi A, Brem H, Quinones-Hinojosa A. Harvey Cushings Early Treatment of Meningiomas: The Untold Story. World Neurosurg. 2011; Nov. 7. [Epub ahead of print] PMID: 22120300
Grossman R, Tyler B, Hwang L, Zadnik P, Lal, B, Javaherian K, Brem H. Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin. J. Neurosurg. 2011;115(6):1139-46. PMID: 21923243.
Chaichana KL, Zaidi H, Pendleton C, McGirt MJ, Grossman R, Weingart JD, Olivi A, Quiones-Hinojosa A, Brem H. The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival. Neurol Res. 2011;33(7):759-64. PMID: 21756557
Tyler B, Wadsworth S, Recinos V, Mehta V, Vellimana A, Li K, Rosenblatt J, Do H, Gallia GL, Siu IM, Wicks RT, Rudek MA, Zhao M, Brem H. Local delivery of rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats. Neuro Oncol. 2011;13(7):700-9. PMID:21727209
Brem SS, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Chiocca EA, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Junck L, Linette GP, Loeffler JS, Maor MH, Michael M, Moots PL, Morrison T, Mrugala M, Nabors LB, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK Jr, Vrionis FD, Wen PY. Central Nervous System Cancers. J Natl Compr Canc Netw. 2011;9(4):352-400. PMID: 21464114
Grossman R, Mukherjee D, Chang DC, Bennett R, Brem H, Olivi A, Quiones-Hinojosa A. Preoperative charlson comorbidity score predicts postoperative outcomes among older intracranial meningioma patients. World Neurosurg. 2011;75(2):279-85. PMID: 21492731
Latimer K, Pendleton C, Olivi A, Cohen-Gadol AA, Brem H, Quiones-Hinojosa A. Harvey Cushings Open and Thorough Documentation of Surgical Mishaps at the Dawn of Neurological Surgery. Arch Surg. 2011;146 (2):226-32. PMID: 21339437
Scott AW, Tyler BM, Masi BC, Upadhyay UM, Patta YR, Grossman R, Basaldella L, Langer RS, Brem H, Cima MJ. Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model. Biomaterials. 2011; 32(10):2532-9. PMID: 21220172
Chaichana KL, Chaichana KK, Olivi A, Weingart JD, Bennett R, Brem H, Quiones-Hinojosa A. Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. J Neurosurg. 2011;114(3):587-94PMID: 20887095.
Grossman R, Mukherjee D, Chang DC, Purtell M, Lim M, Brem H, Quiones-Hinojosa A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Ann Surg Oncol. 2011; 18(2):521-8. PMID: 20809176
Raza SM, Gallia GL, Brem H, Weingart JD, Long DM, Olivi A. Perioperative and long-term outcomes from the management of parasagittal meningiomas invading the superior sagittal sinus. Neurosurgery. 2010; 67(4): 885-93; discussion 893. PMID 20802356
Chaichana KL, Garzon-Muvdi T, Parker S, Weingart JD, Olivi A, Bennett R, Brem H, Quiones-Hinojosa A. Supratentorial Glioblastoma Multiforme: The Role of Surgical Resection Versus Biopsy Among Older Patients. Ann Surg Oncol. 2011; 18(1):239-45. PMID: 20697823
Chaichana KL, Halthore AN, Parker SL, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa A. Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. J Neurosurg. 2011; 114(3):604-12. PMID: 20524825
Grossman R, Mukherjee D, Chaichana KL, Salvatori R, Wand G, Brem H, Chang DC, Quiones-Hinojosa A. Complications and Death Among Elderly Patients Undergoing Pituitary Tumor Surgery. Clin Endocrinol. 2010; Sep;73(3):361-8 PMID: 20455889
McGirt MJ, Brem H. Carmustine wafers (Gliadel) plus concomitant temozolomide therapy after resection of malignant astrocytomas: growing evidence for safety and efficacy. Ann Surg Oncol. 2010;17(7):1729-31. PMID: 20422453
Chaichana KL, Kosztowski T, Niranjan A, Olivi A, Weingart JD, Laterra J, Brem H, Quinones-Hinojosa A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. J.Neurosurg. 2010; 113(2):286-92 PMID 20302391.
Mukherjee D, Zaidi HA, Kosztowski T, Chaichana KL, Brem H, Chang DC, Quinones-Hinojosa A. Disparities in Access to Neuro-oncologic Care in the United States. Arch.Surg. 2010; 145(3): 247-253. PMID 20231625.
Tyler B, Fowers KD, Li KW, Recinos VR, Caplan JM, Hdeib A, Grossman R, Basaldella L, Bekelis K, Pradilla G, Legnani F, Brem H. A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats. J.Neurosurg. 2010; 113(2):210-7; PMID 20001591.
Recinos VR, Tyler BM, Bekelis K, Sunshine SB, Vellimana A, Li KW, Brem H. Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model. Neurosurgery. 2010; 66(3): 530-7; discussion 537. PMID 20173548.
de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J.Clin.Neurosci. 2009; 16(9): 1246-1249. PMID 19560362.
Recinos VR, Bekelis K, Ziegler SG, Vick D, Hertig S, Tyler BM, Li KW, Kosztowski T, Legnani FG, Brem H, Olivi A. Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. J.Neurooncol. 2010; 97(1): 1-10. PMID 19693439.
Slager J, Tyler B, Shikanov A, Domb AJ, Shogen K, Sidransky D, Brem H. Local controlled delivery of anti-neoplastic RNAse to the brain. Pharm.Res. 2009; 26(8): 1838-1846. PMID 19415468.
Chaichana KL, McGirt MJ, Woodworth GF, Datoo G, Tamargo RJ, Weingart J, Olivi A, Brem H, Quinones-Hinojosa A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurol.Res. 2010; 32(4):442-8. PMID 19589201.
McGirt MJ, Chaichana KL, Gathinji M, Attenello FJ, Than K, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa AR. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. J.Neurosurg. 2009; 110(1): 156-162. PMID 18847342.
Rege A, Seifert AC, Schlattman D, Ouyang Y, Li KW, Basaldella L, Brem H, Tyler BM, Thakor NV. Longitudinal IN VIVO Monitoring of rodent GLIOMA MODELS through thinned skull using Laser Speckle Contrast Imaging. J Biomed Opt. 2012 Dec 1;17(12):126017..PMID: 23235836.
Vellimana AK, Recinos VR, Hwang L, Fowers KD, Li KW, Zhang Y, Okonma S, Eberhart CG, Brem H, Tyler BM. Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model. 2012; 147(11):1017-24. PMID:23165616. . J Neurooncol. 2012 Dec 7. [Epub ahead of print]. PMID:23224713
Momin EN, Adams H, Shinohara RT, Frangakis C, Brem H, Quiones-Hinojosa A. Post-Operative 2012: Oct 19 [Epub ahead of print]. PMID:23082884 Mortality After Surgery for Brain Tumors Differs by Insurance Status in the United States. Arch Surg
Chaichana KL, Zadnik P, Weingart JD, Olivi A, Gallia GL, Blakeley J, Lim M, Brem H, Quiones-Hinojosa A. Multiple resections for patients with glioblastoma: prolonging survival. J Neurosurg.
Grossman R, Tyler B, Brem H, Eberhart CG, Wand S, Fu DX, Wen Z, Zhou J. Growth properties of SF 188/V+ human glioma in rats observed by magnetic resonance imaging. J Neurooncol. 2012; 110(3):315-23. PMID:23011120.
Kong S, Senqupta S, Tyler BM, Ma Q, Doucette S, Zhou J, Sahin A, Carter B, Brem H, Junghans RP, Sampath P. Supression of Human Glioma Xenografts with 2nd Generation IL13R-Specific Chimeric Antigen receptor-Modified T Cells. Clin Cancer Res. 2012;18(21):5949-5960.
Grossman R, Rudek MA, Brastianos H, Zadnik P, Brem H, Tyler B, Blakeley JO. The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas. Cancer Chemother Pharmacol. 2012; 70(1):129-39. PMID: 22644796.
Henry Brem, M.D. 14
Link TW, Woodworth GF, Chaichana KL, Grossman SA, Mayer RS, Brem H, Weingart JD, Quinones-Hinojosa A. Hyperglycemia is independently associated with post-operative function loss in patients with primary eloquent glioblastoma. J Clin Neurosci. 2012;19(7):966-1000. PMID:22595358.
Masi BC, Tyler BM, Bow H, Wicks RT, Xue Y, Brem H, Langer R, Cima MJ. Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model. Biomaterials. 2012;33(23):5768-75. PMID:22591609.
Chaichana KL, Pendleton C, Zaidi H, Olivi A, Weingart JD, Gallia GL, Lim M, Brem H, Quinones-Hinojosa A. Seizure Control for Patients Undergoing Meningioma Surgery. World Neurosurg. 2012 Mar 30. [Epub ahead of print]PMID:22469524
Tyler BM, Hdeib A, Caplan J, Legnani FG, Fowers KD, Brem H, Jallo G, Pradilla G. Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel. J Neurosurg Spine . 2012;16(1):93-101 PMID:22208429.
Pendleton C, Olivi A, Brem H, Quinones-Hinojosa A. Harvey Cushings Early Treatment of Meningiomas: The Untold Story. World Neurosurg. 2011; Nov. 7. [Epub ahead of print] PMID: 22120300
Grossman R, Tyler B, Hwang L, Zadnik P, Lal, B, Javaherian K, Brem H. Improvement in the standard treatment for experimental glioma by fusing antibody Fc domain to endostatin. J. Neurosurg. 2011;115(6):1139-46. PMID: 21923243.
Chaichana KL, Zaidi H, Pendleton C, McGirt MJ, Grossman R, Weingart JD, Olivi A, Quiones-Hinojosa A, Brem H. The efficacy of carmustine wafers for older patients with glioblastoma multiforme: prolonging survival. Neurol Res. 2011;33(7):759-64. PMID: 21756557
Tyler B, Wadsworth S, Recinos V, Mehta V, Vellimana A, Li K, Rosenblatt J, Do H, Gallia GL, Siu IM, Wicks RT, Rudek MA, Zhao M, Brem H. Local delivery of rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats. Neuro Oncol. 2011;13(7):700-9. PMID:21727209
Brem SS, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Chiocca EA, Deangelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Junck L, Linette GP, Loeffler JS, Maor MH, Michael M, Moots PL, Morrison T, Mrugala M, Nabors LB, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK Jr, Vrionis FD, Wen PY. Central Nervous System Cancers. J Natl Compr Canc Netw. 2011;9(4):352-400. PMID: 21464114
Grossman R, Mukherjee D, Chang DC, Bennett R, Brem H, Olivi A, Quiones-Hinojosa A. Preoperative charlson comorbidity score predicts postoperative outcomes among older intracranial meningioma patients. World Neurosurg. 2011;75(2):279-85. PMID: 21492731
Latimer K, Pendleton C, Olivi A, Cohen-Gadol AA, Brem H, Quiones-Hinojosa A. Harvey Cushings Open and Thorough Documentation of Surgical Mishaps at the Dawn of Neurological Surgery. Arch Surg. 2011;146 (2):226-32. PMID: 21339437
Scott AW, Tyler BM, Masi BC, Upadhyay UM, Patta YR, Grossman R, Basaldella L, Langer RS, Brem H, Cima MJ. Intracranial microcapsule drug delivery device for the treatment of an experimental gliosarcoma model. Biomaterials. 2011; 32(10):2532-9. PMID: 21220172
Chaichana KL, Chaichana KK, Olivi A, Weingart JD, Bennett R, Brem H, Quiones-Hinojosa A. Surgical outcomes for older patients with glioblastoma multiforme: preoperative factors associated with decreased survival. J Neurosurg. 2011;114(3):587-94PMID: 20887095.
Grossman R, Mukherjee D, Chang DC, Purtell M, Lim M, Brem H, Quiones-Hinojosa A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Ann Surg Oncol. 2011; 18(2):521-8. PMID: 20809176
Raza SM, Gallia GL, Brem H, Weingart JD, Long DM, Olivi A. Perioperative and long-term outcomes from the management of parasagittal meningiomas invading the superior sagittal sinus. Neurosurgery. 2010; 67(4): 885-93; discussion 893. PMID 20802356
Chaichana KL, Garzon-Muvdi T, Parker S, Weingart JD, Olivi A, Bennett R, Brem H, Quiones-Hinojosa A. Supratentorial Glioblastoma Multiforme: The Role of Surgical Resection Versus Biopsy Among Older Patients. Ann Surg Oncol. 2011; 18(1):239-45. PMID: 20697823
Chaichana KL, Halthore AN, Parker SL, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa A. Factors involved in maintaining prolonged functional independence following supratentorial glioblastoma resection. J Neurosurg. 2011; 114(3):604-12. PMID: 20524825
Grossman R, Mukherjee D, Chaichana KL, Salvatori R, Wand G, Brem H, Chang DC, Quiones-Hinojosa A. Complications and Death Among Elderly Patients Undergoing Pituitary Tumor Surgery. Clin Endocrinol. 2010; Sep;73(3):361-8 PMID: 20455889
McGirt MJ, Brem H. Carmustine wafers (Gliadel) plus concomitant temozolomide therapy after resection of malignant astrocytomas: growing evidence for safety and efficacy. Ann Surg Oncol. 2010;17(7):1729-31. PMID: 20422453
Chaichana KL, Kosztowski T, Niranjan A, Olivi A, Weingart JD, Laterra J, Brem H, Quinones-Hinojosa A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. J.Neurosurg. 2010; 113(2):286-92 PMID 20302391.
Mukherjee D, Zaidi HA, Kosztowski T, Chaichana KL, Brem H, Chang DC, Quinones-Hinojosa A. Disparities in Access to Neuro-oncologic Care in the United States. Arch.Surg. 2010; 145(3): 247-253. PMID 20231625.
Tyler B, Fowers KD, Li KW, Recinos VR, Caplan JM, Hdeib A, Grossman R, Basaldella L, Bekelis K, Pradilla G, Legnani F, Brem H. A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats. J.Neurosurg. 2010; 113(2):210-7; PMID 20001591.
Recinos VR, Tyler BM, Bekelis K, Sunshine SB, Vellimana A, Li KW, Brem H. Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model. Neurosurgery. 2010; 66(3): 530-7; discussion 537. PMID 20173548.
de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J.Clin.Neurosci. 2009; 16(9): 1246-1249. PMID 19560362.
Recinos VR, Bekelis K, Ziegler SG, Vick D, Hertig S, Tyler BM, Li KW, Kosztowski T, Legnani FG, Brem H, Olivi A. Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers. J.Neurooncol. 2010; 97(1): 1-10. PMID 19693439.
Slager J, Tyler B, Shikanov A, Domb AJ, Shogen K, Sidransky D, Brem H. Local controlled delivery of anti-neoplastic RNAse to the brain. Pharm.Res. 2009; 26(8): 1838-1846. PMID 19415468.
Chaichana KL, McGirt MJ, Woodworth GF, Datoo G, Tamargo RJ, Weingart J, Olivi A, Brem H, Quinones-Hinojosa A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurol.Res. 2010; 32(4):442-8. PMID 19589201.
McGirt MJ, Chaichana KL, Gathinji M, Attenello FJ, Than K, Olivi A, Weingart JD, Brem H, Quinones-Hinojosa AR. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. J.Neurosurg. 2009; 110(1): 156-162. PMID 18847342.
Research Interests
- Delivery of chemotherapy directly to the brain
- New clinical treatments for brain tumors
- Computer navigation systems used during surgery
- Brain tumor vaccines
- Anti-angiogenesis therapies
More Info
Languages
- English
Additional Resources
Johns Hopkins Comprehensive Brain Tumor Center
Johns Hopkins Acoustic Neuroma Center
Johns Hopkins Glioma Center
Johns Hopkins Meningioma Center
Johns Hopkins Departments of Neurosurgery and Neurology
Dr. Henry Brem's CV
Johns Hopkins Acoustic Neuroma Center
Johns Hopkins Glioma Center
Johns Hopkins Meningioma Center
Johns Hopkins Departments of Neurosurgery and Neurology
Dr. Henry Brem's CV
Videos and Podcasts
Dr. Brem Describes the Spirit of Johns Hopkins Neurosurgery
Patient story: Brain Tumor Patient, Carlos
Dr. Henry Brem, Part 1 of 2 - Johns Hopkins School of Medicine Convocation 2011
Dr. Henry Brem, Part 2 of 2 - Johns Hopkins School of Medicine Convocation 2011
Johns Hopkins Neurosurgery First Annual Harvey Cushing Lecture Part 1 of 3
Johns Hopkins Neurosurgery First Annual Harvey Cushing Lecture Part 2 of 3
Johns Hopkins Neurosurgery First Annual Harvey Cushing Lecture Part 3 of 3
Patient story: Brain Tumor Patient, Carlos
Dr. Henry Brem, Part 1 of 2 - Johns Hopkins School of Medicine Convocation 2011
Dr. Henry Brem, Part 2 of 2 - Johns Hopkins School of Medicine Convocation 2011
Johns Hopkins Neurosurgery First Annual Harvey Cushing Lecture Part 1 of 3
Johns Hopkins Neurosurgery First Annual Harvey Cushing Lecture Part 2 of 3
Johns Hopkins Neurosurgery First Annual Harvey Cushing Lecture Part 3 of 3
Facebook
Twitter
Sharecare
Blogs
YouTube
RSS
Podcasts