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Douglas Paul Clark, MD

Title(s):

Adjunct Professor of Pathology
Adjunct Professor of Oncology

Division Director Cytopathology

Appointment Phone:

410-955-2660

Primary Location:

The Johns Hopkins Hospital

Expertise:

Anatomic Pathology, Thyroid Fine Needle Aspiration Biopsy

Education and Experience

Training

Johns Hopkins University School of Medicine (Baltimore MD)/ (1989)

Residencies

Hospital of the University of Pennsylvania (Philadelphia PA)/ Anatomic Pathology (1992)

Fellowships

Hospital of the University of Pennsylvania (Philadelphia PA)/ Cytopathology (1994)

Certifications

Cytopathology, American Board of Pathology (1994)
Anatomic Pathology, American Board of Pathology (1992)

Locations

The Johns Hopkins Hospital

600 N. Wolfe Street

Hospital Main Entrance - Sheikh Zayed Tower

Baltimore, MD 21287

Appointment Phone: 410-955-2660

Location Map

Johns Hopkins Bayview Medical Center

4940 Eastern Avenue

Baltimore, MD 21224

Appointment Phone: 410-955-2660

Location Map

Department / Division

Pathology

Centers/Institutes

Bio

Biography

Dr. Clark is a Board-Certified Anatomic Pathologist and Cytopathologist. Dr. Clark has been on the pathology faculty of Johns Hopkins School of Medicine for over 14 years, where he currently serves as the Director of the Division of Cytopathology. Dr. Clark received his M.D. degree from The Johns Hopkins School of Medicine, Baltimore, Maryland and his B.A. degree in Biochemistry and Molecular Biology from Northwestern University, Evanston, Illinois. In addition to his training in diagnostic anatomic pathology at the University of Pennsylvania, Dr. Clark has pursued both pre-doctoral and post-doctoral research in molecular biology at The National Institutes of Health and the University of Pennsylvania.

Physician Title

Division Director Cytopathology

Expertise

Anatomic Pathology
Thyroid Fine Needle Aspiration Biopsy

Professional Highlights

Dr. Clark serves on the editorial advisory boards of Cancer Cytopathology, CytoJournal, and Expert Review of Molecular Diagnostics. Dr. Clark has published over 100 original papers, reports, review articles, abstracts, book chapters and books. Dr. Clark has held national pathology leadership positions, including Scientific Program Chair for the Annual Meeting of the American Society of Cytopathology and Subcommittee Chair for the NCI Thyroid Fine Needle Aspiration State of the Science Conference. Dr. Clark also serves on the Scientific Advisory Board for BD/TriPath Oncology and is a founder of BioMarker Strategies, LLC. He is a frequent speaker on the topics of tissue-based cancer diagnostics and molecular biomarkers for targeted cancer therapy.

Research

Research and Publications

Dr. Clark''s current research interests are focused in the area of cancer diagnostics. Dr. Clarks laboratory is interested in the molecular characterization of cellular damage and the discovery of novel biomarkers for cancer. The translational arm of his research laboratory is interested in characterizing molecular alterations in cytologic samples of human tumors and developing molecular biomarkers to guide targeted cancer therapy.

Selected Publications:

Filie AC, Asa S, Geisenger KR, Logani S, Merino M, Nikiforov YE, Clark DP: Utilization of Ancillary Studies in Thyroid Fine Needle Aspirates: A Synopsis of the National Cancer Institute* Thyroid Fine Needle Aspiration State of the Science Conference. Diagn Cytopathol 2008; 36(6):438-441.

Murphy KM, Chen F, Clark DP: Identification of immunohistochemical biomarkers for papillary thyroid carcinoma using gene expression profiling. Human Pathol, 2008; 39(3): 420-426.

Baloch ZW, Cibas ES, Clark DP, Layfield LJ, Ljung B-M, Pitman MB, Abati, A: The National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference: A Summation. Cytojournal 2008; 5(1):6.

Kelly D, Kincaid E, Fansler Z, Rosenthal, Clark DP: Detection of cervical high-grade squamous intraepithelial lesions from cytologic samples using a novel immunocytochemical assay (ProExTM C). Cancer (Cancer Cytopathol) 2006;108:494-500.

Jimeno A, Kulesza P, Wheelhouse J, Chan A, Zhang X, Kincaid E, Chen R, Clark DP, Forastiere A, Hidalgo M: Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy. Bri J Cancer 2007; 96: 952-959.

Jimeno A, Kulesza P, Kincaid E, Bouaroud N, Chan A, Forastiere A, Brahmer J, Clark DP, Hidalgo M: C-fos assessment as a marker of anti-epidermal growth factor receptor effect. Cancer Res 2006 66(4):2385-2390.

Yang B, Guo M, Herman JG, and Clark DP: Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 163(3):1101-1107, 2003.

Research Interests