Title(s):
Professor of Anesthesiology and Critical Care Medicine
Associate Professor of Surgery
Associate Professor of Surgery
Director of Cardiac Anesthesia Division
Executive Vice Chairman, ACCM, The Johns Hopkins University School of Medicine
Executive Vice Chairman, ACCM, The Johns Hopkins University School of Medicine
Appointment Phone:
410-955-7519
Primary Location:
The Johns Hopkins Hospital
Expertise:
Critical Care Medicine
Education and Experience
Training
- Faculty Of Medicine, National University (Cork )/ (1979)
Residencies
- The Johns Hopkins Hospital (Baltimore MD)/ Anesthesiology & Critical Care Med (1985)
Certifications
- Anesthesiology, American Board of Anesthesiology (1986)
Locations
The Johns Hopkins Hospital
600 N. Wolfe Street
Tower 711
Baltimore, MD 21287
Phone: 410-955-7519
Appointment Phone: 410-955-7519
Fax: 410-955-0994
Location Map
Department / Division
-
Anesthesiology and Critical Care Medicine - Cardiac Anesthesia
Centers/Institutes
Bio
Physician Title
Director of Cardiac Anesthesia Division
Executive Vice Chairman, ACCM, The Johns Hopkins University School of Medicine
Executive Vice Chairman, ACCM, The Johns Hopkins University School of Medicine
Expertise
- Critical Care Medicine
Research
Research and Publications
Publications Since 2006
1. White AR, Ryoo SW, Li D, Champion HC, Steppan J, Wang D, Nyhan D, Shoukas AA, Hare JM, Berkowitz DE. Knockdown of arginase 1 restores NO signaling in the vasculature of old rats. Hypertension 2006; 47:245-251.
2. Gao WD, Da T, Nyhan D. Increased cross-bridge cycling rate in stunned myocardium. Am J Physiol Heart Circ Physiol 2006;290:H866-H893.
3. Steppan J, Ryoo S, Schuleri KH, Gregg C, Hasan RK, White AR, Bugaj LJ, Khan M, Santhanam L, Nyhan D, Shoukas A, Hare J, Berkowitz DE. Arginase modulates myocardial contractility by a nitric oxide synthase-1 dependent mechanism. PNAS USA. 2006;103:4759-4764.
4. Ryoo S, Lemmon C, Soucy KG, Gupta G, White AR, Nyhan D, Shoukas A, Romer LH, Berkowitz DE. Oxidized low-density lipoprotein-dependent endothelial arginase Hi activation contributes to impaired nitric oxide signaling. Circ Res. 2006;99: 951-960.
5. Soucy KG, Ryoo S, Benjo A, Lim HK, Gupta G, Sohi JS, Elser J, Aon MA, Nyhan D, Shoukas AA, Berkowitz DE. Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffeness. JAppI Physiol 2006;101:1751-1759.
6. Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, Shoukas A, Berkowitz DE. Mitochondrial arginase II constrains endothelial NOS-3 activity. AJP-Heart, Lung, Physiol. 2007;93:H3317-H3324.
7. Berkowitz DE, Nyhan D. Critical role of the alpha-1 B adrenoreceptors in sympathetically-mediated pressor and contractile responses to hypotension. Circulation. In Review.
8. Benjo A, Thompson RE, Fine D, Hogue CW, Alejo D, Kaw A, Gerstenblith G, Shah A, Berkowitz DE, Nyhan D. Pulse pressure predicts stroke development and acute renal failure after cardiac surgery. Hypertension. 2007;50:630-635.
9a. Tuday EC, Meek JV, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity-induced changes in aortic
stiffness and their role in orthostatic intolerance, J Appl Physiol, 2007;102:853-858.
9b. Associated Editorial: to be published in J Appl Physiol 2007;103:1-2.
10. Santhanam L, Lim HK, Lim HK, Miriel V, Brown T, Patel M, Balanson S, Ryoo S, Anderson M, Irani K, Khanday F, Di Costanzo L, Nyhan D, Hare JM, Christianson DW, Rivers R, Shoukas A, Berkowitz DE. Inducible NO synthase dependent S-nitrosylation and activation of arginasel contributes to age-related endothelial dysfunction. Circ Res. 2007;101:692-702.
11. Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, Shoukas A, Berkowitz DE. Mitochondrial arginase II constrains endothelial NOS-3 activity. AJP - Heart, Circ Physiol. 2007;293:H3317-H3324.
12. Ryoo S, Gupta G, Benjo A, Lim HK, Camara A, Sikka G, Lim HK, Sohi J, Santhanam L, Soucy K, tuday E, Baraban E, Hies M, Gerstenblith G, Nyhan D, Shoukas A, Christianson DW, Alp NJ, Champion HC, Huso D, Berkowitz DE. Endothelial arginase II: a novel target for the treatment of atherosclerosis, Circ Res. Circ Res. 2008;102:923-943.
13. Tuday EC, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity induced changes in aortic stiffness and its role in orthostatic intolerance, J Appl Physiol, 2007;102:853-858.
14. Nyhan D, Berkowitz DE. Perioperative blood pressure management: does central vascular stiffness matter? Anesth Analg. 2008;107:1103-1106.
Chapters and Reviews since 2006
1. Grogan K, Nyhan D, Berkowitz DE. Pharmacology of anesthetic drugs. IN: Cardiac Anesthesia; 5th Edition. JA Kaplan, D Reich, S Konstade, C Lake, eds. Elsevier/Saunders, New York, 2006. Chap 9, pp 165-212.
2. Nyhan D, BlanckTJJ. Cardiac physiology. IN: Mechanisms of Anesthetic Action, 2nd Edition. IN: Basic and Applied Science for Anesthesia. HC Hemmings, Jr., PM Hopkins, eds. CV Mosby, London; Chapter 39.
3. Steppan J, Berkowitz DE, Martinez E, Nyhan D. Diastolic heart function and the elderly. IN: Aging and Anesthesia. F Sieber, ed. McGraw-Hill, Philadelphia, Chapter 16, 2006.
4. Simmonds P, Nyhan D, Berkowitz DE. Cardiovascular pharmacological agents. IN: The Johns Hopkins Manual of Cardiac Surgical Care, 2nd Edition. Eds. JV Conte, WA Baumgartner, SG Owens, T Dorman. Elsevier, Philadelphia, PA. Chapter 2, 2008.
5. Dorman T, Nyhan D. Postoperative hemodynamic management. IN: The Johns Hopkins Manual of Cardiac Surgical Care, 2nd Edition. Eds. JV Conte, WA Baumgartner, SG Owens, T Dorman. Elsevier, Philadelphia, PA. Chapter 9, 2008.
6. Grogan K, Nyhan D, Berkowitz D. Pharmacology of anesthetic drugs. IN: Cardiac Anesthesia, &h Edition. JA Kaplan, D Reich, S Konstade, C Lake, eds. Elsevier/Saunders, New York. Chapter 7, 2008.
1. White AR, Ryoo SW, Li D, Champion HC, Steppan J, Wang D, Nyhan D, Shoukas AA, Hare JM, Berkowitz DE. Knockdown of arginase 1 restores NO signaling in the vasculature of old rats. Hypertension 2006; 47:245-251.
2. Gao WD, Da T, Nyhan D. Increased cross-bridge cycling rate in stunned myocardium. Am J Physiol Heart Circ Physiol 2006;290:H866-H893.
3. Steppan J, Ryoo S, Schuleri KH, Gregg C, Hasan RK, White AR, Bugaj LJ, Khan M, Santhanam L, Nyhan D, Shoukas A, Hare J, Berkowitz DE. Arginase modulates myocardial contractility by a nitric oxide synthase-1 dependent mechanism. PNAS USA. 2006;103:4759-4764.
4. Ryoo S, Lemmon C, Soucy KG, Gupta G, White AR, Nyhan D, Shoukas A, Romer LH, Berkowitz DE. Oxidized low-density lipoprotein-dependent endothelial arginase Hi activation contributes to impaired nitric oxide signaling. Circ Res. 2006;99: 951-960.
5. Soucy KG, Ryoo S, Benjo A, Lim HK, Gupta G, Sohi JS, Elser J, Aon MA, Nyhan D, Shoukas AA, Berkowitz DE. Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffeness. JAppI Physiol 2006;101:1751-1759.
6. Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, Shoukas A, Berkowitz DE. Mitochondrial arginase II constrains endothelial NOS-3 activity. AJP-Heart, Lung, Physiol. 2007;93:H3317-H3324.
7. Berkowitz DE, Nyhan D. Critical role of the alpha-1 B adrenoreceptors in sympathetically-mediated pressor and contractile responses to hypotension. Circulation. In Review.
8. Benjo A, Thompson RE, Fine D, Hogue CW, Alejo D, Kaw A, Gerstenblith G, Shah A, Berkowitz DE, Nyhan D. Pulse pressure predicts stroke development and acute renal failure after cardiac surgery. Hypertension. 2007;50:630-635.
9a. Tuday EC, Meek JV, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity-induced changes in aortic
stiffness and their role in orthostatic intolerance, J Appl Physiol, 2007;102:853-858.
9b. Associated Editorial: to be published in J Appl Physiol 2007;103:1-2.
10. Santhanam L, Lim HK, Lim HK, Miriel V, Brown T, Patel M, Balanson S, Ryoo S, Anderson M, Irani K, Khanday F, Di Costanzo L, Nyhan D, Hare JM, Christianson DW, Rivers R, Shoukas A, Berkowitz DE. Inducible NO synthase dependent S-nitrosylation and activation of arginasel contributes to age-related endothelial dysfunction. Circ Res. 2007;101:692-702.
11. Lim HK, Lim HK, Ryoo S, Benjo A, Shuleri K, Miriel V, Baraban E, Camara A, Soucy K, Nyhan D, Shoukas A, Berkowitz DE. Mitochondrial arginase II constrains endothelial NOS-3 activity. AJP - Heart, Circ Physiol. 2007;293:H3317-H3324.
12. Ryoo S, Gupta G, Benjo A, Lim HK, Camara A, Sikka G, Lim HK, Sohi J, Santhanam L, Soucy K, tuday E, Baraban E, Hies M, Gerstenblith G, Nyhan D, Shoukas A, Christianson DW, Alp NJ, Champion HC, Huso D, Berkowitz DE. Endothelial arginase II: a novel target for the treatment of atherosclerosis, Circ Res. Circ Res. 2008;102:923-943.
13. Tuday EC, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity induced changes in aortic stiffness and its role in orthostatic intolerance, J Appl Physiol, 2007;102:853-858.
14. Nyhan D, Berkowitz DE. Perioperative blood pressure management: does central vascular stiffness matter? Anesth Analg. 2008;107:1103-1106.
Chapters and Reviews since 2006
1. Grogan K, Nyhan D, Berkowitz DE. Pharmacology of anesthetic drugs. IN: Cardiac Anesthesia; 5th Edition. JA Kaplan, D Reich, S Konstade, C Lake, eds. Elsevier/Saunders, New York, 2006. Chap 9, pp 165-212.
2. Nyhan D, BlanckTJJ. Cardiac physiology. IN: Mechanisms of Anesthetic Action, 2nd Edition. IN: Basic and Applied Science for Anesthesia. HC Hemmings, Jr., PM Hopkins, eds. CV Mosby, London; Chapter 39.
3. Steppan J, Berkowitz DE, Martinez E, Nyhan D. Diastolic heart function and the elderly. IN: Aging and Anesthesia. F Sieber, ed. McGraw-Hill, Philadelphia, Chapter 16, 2006.
4. Simmonds P, Nyhan D, Berkowitz DE. Cardiovascular pharmacological agents. IN: The Johns Hopkins Manual of Cardiac Surgical Care, 2nd Edition. Eds. JV Conte, WA Baumgartner, SG Owens, T Dorman. Elsevier, Philadelphia, PA. Chapter 2, 2008.
5. Dorman T, Nyhan D. Postoperative hemodynamic management. IN: The Johns Hopkins Manual of Cardiac Surgical Care, 2nd Edition. Eds. JV Conte, WA Baumgartner, SG Owens, T Dorman. Elsevier, Philadelphia, PA. Chapter 9, 2008.
6. Grogan K, Nyhan D, Berkowitz D. Pharmacology of anesthetic drugs. IN: Cardiac Anesthesia, &h Edition. JA Kaplan, D Reich, S Konstade, C Lake, eds. Elsevier/Saunders, New York. Chapter 7, 2008.
Research Interests
- Vascular Aging, Underlying Mechanisms
More Info
Languages
- English
Memberships
American Society of Anesthesiologists
American Heart Association
Membership of the Royal College of Physicians of Ireland
American Heart Association
Membership of the Royal College of Physicians of Ireland
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