Gregory James Kato, MD

Morris CR, Kato G, Poljakovic M, Blackwelder WC, Hazen S, Vichinsky EP, Morris SM Jr, Gladwin M. (2005) Dysregulated arginine metabolism contributes to endothelial dysfunction, pulmonary hypertension and mortality in sickle cell disease. JAMA 294: 81-90.
Kato GJ, Martyr S, Blackwelder WC, et al. (2005) Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality. Br J Haematol 130:943-53.
Machado RF, Martyr S, Kato GJ, Barst RJ, Anthi A, Robinson MR, Hunter L, Coles W, Nichols J, Hunter C, Sachdev V, Castro O, Gladwin MT. Sildenafil therapy in patients with sickle cell disease and pulmonary hypertension. Br J Haematol. 2005 Aug;130(3):445-53.
Kato GJ, McGowan V, Machado RF, Little JA, Taylor VI JA, Morris CR, Nichols JS, Wang X, Poljakovic M, Morris Jr. SM, Gladwin MT. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension and death in patients with sickle cell disease. Blood 2006; 107:2279-85.
Machado RF, Anthi A, Steinberg MH, Bonds D, Sachdev V, Kato GJ, Taveira-DaSilva AM, Ballas SK, Blackwelder W, Xu X, Hunter L, Barton B, Waclawiw M, Castro O, Gladwin MT; MSH Investigators. N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. JAMA. 2006;296:310-8.
Kato GJ, Gladwin MT. A Novel Defense against Hemolytic-Oxidative Stress. Blood, 2006; 108:2504-2505.
Kato GJ, Gladwin MT, Steinberg MH. Deconstructing Sickle Cell Disease: Reappraisal of the Role of Hemolysis in the Development of Clinical Subphenotypes. Blood Reviews, 2007; 21:37-47.
Sachdev V, Machado RF, Shizukuda Y, Rao Y, Sidenko S, Ernst I, St. Peter M, Coles WA, Rosing D, Blackwelder WC, Castro O, Kato GJ, Gladwin MT. Diastolic Dysfunction is an Independent Risk Factor for Death in Patients with Sickle Cell Disease. J Am Coll Cardiol. 2007; 49:472-9
Machado RF, Mack AK, Martyr S, Barnett C, MacArthur P, Sachdev V, Ernst I, Hunter LA, Coles WA, Nichols JP, Kato GJ, and Gladwin MT. Severity of Pulmonary Hypertension During Vaso-occlusive Pain Crisis and Exercise in Patients with Sickle Cell Disease. Br J Haematol. 2007; 136:319-25.
Kato GJ, Onyekwere OC, Gladwin MT. Pulmonary Hypertension in Sickle Cell Disease: Relevance to Children. Pediatr Hematol Oncol, 2007; 24:159-170.
Villagra J, Shiva S, Hunter LA, Machado RF, Gladwin MT, Kato GJ. Platelet Activation in Patients with Sickle Disease, Hemolysis-Associated Pulmonary Hypertension and Nitric Oxide Scavenging by Cell-Free Hemoglobin. Blood. 2007; 110:2166-72.
Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor IV JG, Kato GJ, Gladwin MT, Steinberg MH. A Network Model to Predict the Risk of Death in Sickle Cell Disease. Blood, 2007, 110: 2727-2735.
Gladwin MT, Kato GJ. Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and the blood) thickens. Haematologica, 2008; 93:1-3.
Kumkhaek C, Taylor VI JG, Zhu J, Hoppe C, Kato GJ, Rodgers GP. Fetal Hemoglobin Response to Hydroxyurea Treatment and SAR1A Promoter Polymorphisms in Sickle Cell Anemia. Br J Haematol, 2008; 141:254-9.
Taylor JG 4th, Nolan VG, Mendelsohn L, Kato GJ, Gladwin MT, Steinberg MH. Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain. PLoS ONE, 2008; 3:e2095.
Mack AK, McGowan II VR, Ackah D, Tremonti CK, Barnett C, Machado RF, Gladwin MT, Kato GJ. Sodium Nitrite Promotes Regional Blood Flow in Patients with Sickle Cell Disease. Br J Haematol, 2008; 6:971-8.
Kato GJ, Gladwin MT. Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy. JAMA, 2008; 300:2638-46.
Yuditskaya S, Tumblin A, Hoehn GT, Wang G, Drake SK, Xu X, Ying S, Remaley AT, Shen RF, Munson PJ, Suffredini AF, Kato GJ. Proteomic Identification of Altered Apolipoprotein Patterns in Pulmonary Hypertension and Vasculopathy of Sickle Cell Disease. Blood, 2009; 5: 1122-8.
Minniti CP, Sable C, Cambell A, Rana S, Ensing G, Dham N, Onyekwere O, Nourai M, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR. Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disese: association with hemolysis and hemoglobin oxygen desaturation. Haematologica, 2009; 94:340-7.
Kato GJ, Wang Z, Machado RF, Blackwelder WC, Taylor 6th JG, Hazen SL. Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death. Br J Haematol., in press.