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Multiple Endocrine Neoplasia, Type
2B (MEN 2B)
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| Gene: |
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RET |
| Test: |
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Direct mutation analysis by gene sequencing of the coding
regions the RET gene, exons 8, 10, 11, 13, 14, 15, 16
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Clinical Description: |
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MEN 2B is characterized by medullary
thyroid carcinoma and an increased risk for pheochromocytoma.
Patients also have a 'Marfanoid' body habitus and increased risk
for neuromas of the lips and tongue and intestinal
ganglioneuromatosis.
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Inheritance Pattern: |
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Autosomal Dominant |
CPT Codes:
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838891 x 1
83898 x 7
83904 x 14
83909 x 14
83912 x 1
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| Sensitivity: |
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At least 96%
of patients with MEN 2B will have a RET gene mutation
detectable by this test panel |
| Cost: |
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$1022
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| Turn
Around Time: |
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4 weeks |
| Special Considerations: |
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Clinical
history on affected individual is requested.
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Go to Sample Requirements
Go to Requisition and
Billing forms
Go to information on MEN
For patients and families
For professionals
Go to Patient and Family
Page for general resources on genetic testing.
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