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Diabetes Research Center

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Integrated Physiology

Analytical Subcore

Director

Andrew Wolfe, Ph.D.
awolfe3@jhmi.edu

Multiplex Assay Detection Systems

(Luminex platform, BioTek platform)

Comprehensive Laboratory Animal Monitoring System (CLAMS)

Food intake
Paired feeding

Locomotion, circadian activity
Resting energy expenditure
Oxygen consumption
Carbon dioxide production
Heat generation

Training in CLAMS and investigator-directed CLAMS
Full-service CLAMS protocols are available as an independent service.

Body Composition

(DEXA, qMRI)


In Vivo Dynamic Physiology Subcore

Director

Sheng Bi, M.D., M.M.
sbi@jhmi.edu

Associate Director

Timothy Moran, Ph.D.
tmoran@jhmi.edu

Dynamic Physiologic Testing

Expertise, training and advice in:

Intraperitonal glucose tolerance test
Oral gavage
Oral glucose tolerance test
Insulin tolerance test
Pyruvate conversion test
Insulin secretion test

Tracer-Based In Vivo Substrate Handling
Euglycemic Clamp in Rodents
Optogentic Selective Neuronal Stimulation