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Welcome to the Lloyd S. Miller Laboratory at the Johns Hopkins Department of Dermatology.
Our goal is to understand mechanisms of protective immune responses against the common bacterial skin pathogen Staphylococcus aureus. To study these infections we have employed advanced in vivo bioluminescence and fluorescence imaging techniques to track both bacterial clearance and the host immune response noninvasively and longitudinally over time. In addition, we have also developed innovative human skin culture systems, including full-thickness human skin explants and organotypic keratinocyte skin cultures. This area of research is highly significant, since Staphylococcus aureus skin infections represent a major public health threat in the U.S. due to their increasing incidence and the widespread emergence of methicillin-resistant S. aureus (MRSA) and multi-drug resistant strains. Our research is focused on providing the groundwork for future immunotherapies and vaccination strategies against these important human pathogens.
In addition to our work in the skin, we have also begun to study the protective immune responses and novel antibacterial coatings to help treat or prevent post-operative staphylococcal orthopaedic implant infections, which represent a devastating complication after orthopaedic surgical procedures. To study these infections, we have combined the surgical placement of orthopaedic-grade metallic implants with in vivo bioluminescence and fluorescence imaging to noninvasively monitor the infection and host response. This research will provide new insights into protective immune responses and novel treatments against orthopaedic and other surgical implant infections.
Please contact us if you would like to learn more about our work.